6HIQ

Mouse serotonin 5-HT3 receptor, serotonin-bound, I2 conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0045211	cellular_component	postsynaptic membrane
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0045211	cellular_component	postsynaptic membrane
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0045211	cellular_component	postsynaptic membrane
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0045211	cellular_component	postsynaptic membrane
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0015276	molecular_function	ligand-gated monoatomic ion channel activity
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0045211	cellular_component	postsynaptic membrane

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CsLdIynFPfDvqnC

Chain	Residue	Details
A	CYS135-CYS149

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	130
Details	TRANSMEM: Helical; Name=1 => ECO:0000255

Chain	Residue	Details
A	LEU221-ASP247
E	LEU221-ASP247
B	LEU221-ASP247
C	LEU221-ASP247
D	LEU221-ASP247

---

site_id	SWS_FT_FI2
Number of Residues	715
Details	TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:25119048

Chain	Residue	Details
A	SER248-VAL252
D	GLU300-ARG439
A	GLU300-ARG439
E	SER248-VAL252
E	GLU300-ARG439
B	SER248-VAL252
B	GLU300-ARG439
C	SER248-VAL252
C	GLU300-ARG439
D	SER248-VAL252

---

site_id	SWS_FT_FI3
Number of Residues	90
Details	TRANSMEM: Helical; Name=2 => ECO:0000255

Chain	Residue	Details
A	SER253-ASP271
E	SER253-ASP271
B	SER253-ASP271
C	SER253-ASP271
D	SER253-ASP271

---

site_id	SWS_FT_FI4
Number of Residues	45
Details	TOPO_DOM: Extracellular => ECO:0000305|PubMed:25119048

Chain	Residue	Details
A	THR272-PRO281
E	THR272-PRO281
B	THR272-PRO281
C	THR272-PRO281
D	THR272-PRO281

---

site_id	SWS_FT_FI5
Number of Residues	90
Details	TRANSMEM: Helical; Name=3 => ECO:0000255

Chain	Residue	Details
A	PRO281-ALA299
E	PRO281-ALA299
B	PRO281-ALA299
C	PRO281-ALA299
D	PRO281-ALA299

---

site_id	SWS_FT_FI6
Number of Residues	95
Details	TRANSMEM: Helical; Name=4 => ECO:0000255

Chain	Residue	Details
A	ILE440-TRP459
E	ILE440-TRP459
B	ILE440-TRP459
C	ILE440-TRP459
D	ILE440-TRP459

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site_id	SWS_FT_FI7
Number of Residues	15
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	VAL83
C	VAL83
C	CYS149
C	ILE165
D	VAL83
D	CYS149
D	ILE165
A	CYS149
A	ILE165
E	VAL83
E	CYS149
E	ILE165
B	VAL83
B	CYS149
B	ILE165

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