6HGZ
ADP-ribosylserine hydrolase ARH3 of Latimeria chalumnae in complex with ADP-ribose
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004649 | molecular_function | poly(ADP-ribose) glycohydrolase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005694 | cellular_component | chromosome |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0060546 | biological_process | negative regulation of necroptotic process |
| A | 0140290 | biological_process | peptidyl-serine ADP-deribosylation |
| A | 0140292 | molecular_function | ADP-ribosylserine hydrolase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004649 | molecular_function | poly(ADP-ribose) glycohydrolase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005694 | cellular_component | chromosome |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0060546 | biological_process | negative regulation of necroptotic process |
| B | 0140290 | biological_process | peptidyl-serine ADP-deribosylation |
| B | 0140292 | molecular_function | ADP-ribosylserine hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 401 |
| Chain | Residue |
| A | THR62 |
| A | ASP63 |
| A | ASP64 |
| A | ASP305 |
| A | MG402 |
| A | AR6403 |
| A | HOH587 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | ASP305 |
| A | THR306 |
| A | MG401 |
| A | AR6403 |
| A | GLU33 |
| A | ASP303 |
| site_id | AC3 |
| Number of Residues | 30 |
| Details | binding site for residue AR6 A 403 |
| Chain | Residue |
| A | GLU33 |
| A | ASP63 |
| A | ASP64 |
| A | GLY101 |
| A | GLY103 |
| A | ALA104 |
| A | GLY105 |
| A | VAL106 |
| A | PHE129 |
| A | GLY133 |
| A | SER134 |
| A | TYR135 |
| A | GLY136 |
| A | ASN137 |
| A | GLY138 |
| A | HIS168 |
| A | ILE260 |
| A | ASP303 |
| A | ASP305 |
| A | THR306 |
| A | MG401 |
| A | MG402 |
| A | HOH517 |
| A | HOH518 |
| A | HOH555 |
| A | HOH581 |
| A | HOH592 |
| B | ALA37 |
| B | ASP42 |
| B | HOH515 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue MG B 401 |
| Chain | Residue |
| B | THR62 |
| B | ASP63 |
| B | ASP64 |
| B | ASP305 |
| B | MG402 |
| B | AR6403 |
| B | HOH572 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 402 |
| Chain | Residue |
| B | GLU33 |
| B | ASP303 |
| B | ASP305 |
| B | THR306 |
| B | MG401 |
| B | AR6403 |
| site_id | AC6 |
| Number of Residues | 28 |
| Details | binding site for residue AR6 B 403 |
| Chain | Residue |
| B | GLU33 |
| B | ASP63 |
| B | ASP64 |
| B | GLY101 |
| B | GLY103 |
| B | ALA104 |
| B | GLY105 |
| B | VAL106 |
| B | PHE129 |
| B | GLY133 |
| B | SER134 |
| B | TYR135 |
| B | GLY136 |
| B | ASN137 |
| B | GLY138 |
| B | HIS168 |
| B | ILE260 |
| B | ASP303 |
| B | ASP305 |
| B | THR306 |
| B | MG401 |
| B | MG402 |
| B | HOH518 |
| B | HOH528 |
| B | HOH535 |
| B | HOH542 |
| B | HOH564 |
| B | HOH572 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 404 |
| Chain | Residue |
| B | PRO79 |
| B | ASP80 |
| B | ASP155 |
| B | PHE159 |
| B | GLN352 |
| B | HOH590 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 405 |
| Chain | Residue |
| A | GLU83 |
| B | GLU83 |
| B | VAL84 |
| B | SER119 |
| B | ASP120 |
| B | VAL121 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"34321462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AQM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30472116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34321462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AQM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30472116","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Glutamate flap","evidences":[{"source":"UniProtKB","id":"Q9NX46","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
