6HGE

Crystal structure of Alpha1-antichymotrypsin variant NewBG-I in the uncleaved S-conformation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004867	molecular_function	serine-type endopeptidase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0006953	biological_process	acute-phase response
A	0006954	biological_process	inflammatory response
A	0019216	biological_process	regulation of lipid metabolic process
A	0030277	biological_process	maintenance of gastrointestinal epithelium
A	0030414	molecular_function	peptidase inhibitor activity
A	0031012	cellular_component	extracellular matrix
A	0031093	cellular_component	platelet alpha granule lumen
A	0034097	biological_process	response to cytokine
A	0034774	cellular_component	secretory granule lumen
A	0035578	cellular_component	azurophil granule lumen
A	0070062	cellular_component	extracellular exosome
A	0072562	cellular_component	blood microparticle
B	0003677	molecular_function	DNA binding
B	0004867	molecular_function	serine-type endopeptidase inhibitor activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0006953	biological_process	acute-phase response
B	0006954	biological_process	inflammatory response
B	0019216	biological_process	regulation of lipid metabolic process
B	0030277	biological_process	maintenance of gastrointestinal epithelium
B	0030414	molecular_function	peptidase inhibitor activity
B	0031012	cellular_component	extracellular matrix
B	0031093	cellular_component	platelet alpha granule lumen
B	0034097	biological_process	response to cytokine
B	0034774	cellular_component	secretory granule lumen
B	0035578	cellular_component	azurophil granule lumen
B	0070062	cellular_component	extracellular exosome
B	0072562	cellular_component	blood microparticle
C	0003677	molecular_function	DNA binding
C	0004867	molecular_function	serine-type endopeptidase inhibitor activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0006953	biological_process	acute-phase response
C	0006954	biological_process	inflammatory response
C	0019216	biological_process	regulation of lipid metabolic process
C	0030277	biological_process	maintenance of gastrointestinal epithelium
C	0030414	molecular_function	peptidase inhibitor activity
C	0031012	cellular_component	extracellular matrix
C	0031093	cellular_component	platelet alpha granule lumen
C	0034097	biological_process	response to cytokine
C	0034774	cellular_component	secretory granule lumen
C	0035578	cellular_component	azurophil granule lumen
C	0070062	cellular_component	extracellular exosome
C	0072562	cellular_component	blood microparticle
D	0003677	molecular_function	DNA binding
D	0004867	molecular_function	serine-type endopeptidase inhibitor activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0006953	biological_process	acute-phase response
D	0006954	biological_process	inflammatory response
D	0019216	biological_process	regulation of lipid metabolic process
D	0030277	biological_process	maintenance of gastrointestinal epithelium
D	0030414	molecular_function	peptidase inhibitor activity
D	0031012	cellular_component	extracellular matrix
D	0031093	cellular_component	platelet alpha granule lumen
D	0034097	biological_process	response to cytokine
D	0034774	cellular_component	secretory granule lumen
D	0035578	cellular_component	azurophil granule lumen
D	0070062	cellular_component	extracellular exosome
D	0072562	cellular_component	blood microparticle

Functional Information from PROSITE/UniProt

site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. VRFNRPFLMiI

Chain	Residue	Details
A	VAL370-ILE380
D	VAL370-ILE380
B	VAL370-ILE380
C	VAL370-ILE380

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Site: {"description":"Reactive bond"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	DNA binding: {}

Chain

Residue

Details

---