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6HG3

Hybrid dihydroorotase domain of human CAD with E. coli flexible loop, bound to dihydroorotate

Functional Information from GO Data
ChainGOidnamespacecontents
A0016787molecular_functionhydrolase activity
A0016810molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A0016812molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue FMT A 1901
ChainResidue
AHIS1736
AHIS1736
AARG1739
AARG1739

site_idAC2
Number of Residues8
Detailsbinding site for residue FMT A 1902
ChainResidue
AHIS1613
AHOH2017
AHOH2078
APRO1588
AILE1589
AARG1610
ASER1611
AVAL1612

site_idAC3
Number of Residues6
Detailsbinding site for residue ZN A 1903
ChainResidue
AKCX1556
AHIS1592
AHIS1616
AZN1904
ADOR1906
AHOH2140

site_idAC4
Number of Residues7
Detailsbinding site for residue ZN A 1904
ChainResidue
AHIS1471
AHIS1473
AKCX1556
AASP1688
AZN1903
AHOH2005
AHOH2140

site_idAC5
Number of Residues4
Detailsbinding site for residue FMT A 1905
ChainResidue
ASER1585
AARG1610
ASER1611
AHOH2078

site_idAC6
Number of Residues14
Detailsbinding site for residue DOR A 1906
ChainResidue
AHIS1473
AARG1475
AASN1505
ATYR1558
AHIS1592
AVAL1662
AARG1663
AALA1690
AHIS1692
APRO1704
AGLY1705
AZN1903
AHOH2009
AHOH2140

Functional Information from PROSITE/UniProt
site_idPS00482
Number of Residues9
DetailsDIHYDROOROTASE_1 Dihydroorotase signature 1. DVHVHLReP
ChainResidueDetails
AASP1469-PRO1477

site_idPS00483
Number of Residues12
DetailsDIHYDROOROTASE_2 Dihydroorotase signature 2. ASDhAPHtleeK
ChainResidueDetails
AALA1686-LYS1697

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsActive site: {"description":"For DHOase activity","evidences":[{"source":"UniProtKB","id":"P05020","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24332717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4C6D","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24332717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4C6Q","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsBinding site: {"description":"via carbamate group","evidences":[{"source":"PubMed","id":"24332717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4C6D","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"24332717","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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