6HG1

Hybrid dihydroorotase domain of human CAD with E. coli flexible loop in apo state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016787	molecular_function	hydrolase activity
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0016812	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue ZN A 1901

Chain	Residue
A	HIS1471
A	KCX1556
A	HIS1592
A	HIS1616
A	ZN1902
A	HOH2010

---

site_id	AC2
Number of Residues	6
Details	binding site for residue ZN A 1902

Chain	Residue
A	ASP1688
A	ZN1901
A	HOH2010
A	HIS1471
A	HIS1473
A	KCX1556

---

site_id	AC3
Number of Residues	2
Details	binding site for residue FMT A 1903

Chain	Residue
A	PRO1746
A	GLU1748

---

site_id	AC4
Number of Residues	7
Details	binding site for residue FMT A 1904

Chain	Residue
A	PRO1504
A	KCX1556
A	TYR1558
A	SER1566
A	HIS1568
A	HOH2024
A	HOH2035

---

site_id	AC5
Number of Residues	8
Details	binding site for residue FMT A 1905

Chain	Residue
A	PRO1588
A	ILE1589
A	ARG1610
A	SER1611
A	VAL1612
A	HIS1613
A	HOH2001
A	HOH2039

---

site_id	AC6
Number of Residues	4
Details	binding site for residue FMT A 1906

Chain	Residue
A	HIS1736
A	HIS1736
A	ARG1739
A	ARG1739

---

Functional Information from PROSITE/UniProt

site_id	PS00482
Number of Residues	9
Details	DIHYDROOROTASE_1 Dihydroorotase signature 1. DVHVHLReP

Chain	Residue	Details
A	ASP1469-PRO1477

---

site_id	PS00483
Number of Residues	12
Details	DIHYDROOROTASE_2 Dihydroorotase signature 2. ASDhAPHtleeK

Chain	Residue	Details
A	ALA1686-LYS1697

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00219","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15610022","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24332717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4C6D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00219","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11401542","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15826651","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1J79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XGE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24332717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4C6Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"description":"via carbamate group","evidences":[{"source":"HAMAP-Rule","id":"MF_00219","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11401542","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15826651","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1J79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XGE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00219","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11401542","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15826651","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1J79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XGE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"HAMAP-Rule","id":"MF_00219","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11401542","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15826651","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1J79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XGE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Active site: {"description":"For DHOase activity","evidences":[{"source":"UniProtKB","id":"P05020","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"description":"via carbamate group","evidences":[{"source":"PubMed","id":"24332717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4C6D","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"24332717","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 630

Chain	Residue	Details
A	HIS1471	metal ligand
A	HIS1473	metal ligand
A	ALA1560	metal ligand
A	GLN1596	metal ligand
A	LYS1620	metal ligand
A	HIS1689	metal ligand, proton acceptor, proton donor

---