6HEC

PAN-proteasome in state 4

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000502	cellular_component	proteasome complex
1	0004175	molecular_function	endopeptidase activity
1	0004298	molecular_function	threonine-type endopeptidase activity
1	0005515	molecular_function	protein binding
1	0005737	cellular_component	cytoplasm
1	0005839	cellular_component	proteasome core complex
1	0006508	biological_process	proteolysis
1	0008233	molecular_function	peptidase activity
1	0010498	biological_process	proteasomal protein catabolic process
1	0016787	molecular_function	hydrolase activity
1	0019774	cellular_component	proteasome core complex, beta-subunit complex
1	0051603	biological_process	proteolysis involved in protein catabolic process
2	0000502	cellular_component	proteasome complex
2	0004175	molecular_function	endopeptidase activity
2	0004298	molecular_function	threonine-type endopeptidase activity
2	0005515	molecular_function	protein binding
2	0005737	cellular_component	cytoplasm
2	0005839	cellular_component	proteasome core complex
2	0006508	biological_process	proteolysis
2	0008233	molecular_function	peptidase activity
2	0010498	biological_process	proteasomal protein catabolic process
2	0016787	molecular_function	hydrolase activity
2	0019774	cellular_component	proteasome core complex, beta-subunit complex
2	0051603	biological_process	proteolysis involved in protein catabolic process
3	0000502	cellular_component	proteasome complex
3	0004175	molecular_function	endopeptidase activity
3	0004298	molecular_function	threonine-type endopeptidase activity
3	0005515	molecular_function	protein binding
3	0005737	cellular_component	cytoplasm
3	0005839	cellular_component	proteasome core complex
3	0006508	biological_process	proteolysis
3	0008233	molecular_function	peptidase activity
3	0010498	biological_process	proteasomal protein catabolic process
3	0016787	molecular_function	hydrolase activity
3	0019774	cellular_component	proteasome core complex, beta-subunit complex
3	0051603	biological_process	proteolysis involved in protein catabolic process
4	0000502	cellular_component	proteasome complex
4	0004175	molecular_function	endopeptidase activity
4	0004298	molecular_function	threonine-type endopeptidase activity
4	0005515	molecular_function	protein binding
4	0005737	cellular_component	cytoplasm
4	0005839	cellular_component	proteasome core complex
4	0006508	biological_process	proteolysis
4	0008233	molecular_function	peptidase activity
4	0010498	biological_process	proteasomal protein catabolic process
4	0016787	molecular_function	hydrolase activity
4	0019774	cellular_component	proteasome core complex, beta-subunit complex
4	0051603	biological_process	proteolysis involved in protein catabolic process
5	0000502	cellular_component	proteasome complex
5	0004175	molecular_function	endopeptidase activity
5	0004298	molecular_function	threonine-type endopeptidase activity
5	0005515	molecular_function	protein binding
5	0005737	cellular_component	cytoplasm
5	0005839	cellular_component	proteasome core complex
5	0006508	biological_process	proteolysis
5	0008233	molecular_function	peptidase activity
5	0010498	biological_process	proteasomal protein catabolic process
5	0016787	molecular_function	hydrolase activity
5	0019774	cellular_component	proteasome core complex, beta-subunit complex
5	0051603	biological_process	proteolysis involved in protein catabolic process
6	0000502	cellular_component	proteasome complex
6	0004175	molecular_function	endopeptidase activity
6	0004298	molecular_function	threonine-type endopeptidase activity
6	0005515	molecular_function	protein binding
6	0005737	cellular_component	cytoplasm
6	0005839	cellular_component	proteasome core complex
6	0006508	biological_process	proteolysis
6	0008233	molecular_function	peptidase activity
6	0010498	biological_process	proteasomal protein catabolic process
6	0016787	molecular_function	hydrolase activity
6	0019774	cellular_component	proteasome core complex, beta-subunit complex
6	0051603	biological_process	proteolysis involved in protein catabolic process
7	0000502	cellular_component	proteasome complex
7	0004175	molecular_function	endopeptidase activity
7	0004298	molecular_function	threonine-type endopeptidase activity
7	0005515	molecular_function	protein binding
7	0005737	cellular_component	cytoplasm
7	0005839	cellular_component	proteasome core complex
7	0006508	biological_process	proteolysis
7	0008233	molecular_function	peptidase activity
7	0010498	biological_process	proteasomal protein catabolic process
7	0016787	molecular_function	hydrolase activity
7	0019774	cellular_component	proteasome core complex, beta-subunit complex
7	0051603	biological_process	proteolysis involved in protein catabolic process
A	0000502	cellular_component	proteasome complex
A	0004175	molecular_function	endopeptidase activity
A	0004298	molecular_function	threonine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0010498	biological_process	proteasomal protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0004175	molecular_function	endopeptidase activity
B	0004298	molecular_function	threonine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0010498	biological_process	proteasomal protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0000502	cellular_component	proteasome complex
C	0004175	molecular_function	endopeptidase activity
C	0004298	molecular_function	threonine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0010498	biological_process	proteasomal protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0000502	cellular_component	proteasome complex
D	0004175	molecular_function	endopeptidase activity
D	0004298	molecular_function	threonine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0010498	biological_process	proteasomal protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0000502	cellular_component	proteasome complex
E	0004175	molecular_function	endopeptidase activity
E	0004298	molecular_function	threonine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0010498	biological_process	proteasomal protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0004175	molecular_function	endopeptidase activity
F	0004298	molecular_function	threonine-type endopeptidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0010498	biological_process	proteasomal protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0051603	biological_process	proteolysis involved in protein catabolic process
G	0000502	cellular_component	proteasome complex
G	0004175	molecular_function	endopeptidase activity
G	0004298	molecular_function	threonine-type endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0010498	biological_process	proteasomal protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0051603	biological_process	proteolysis involved in protein catabolic process
H	0000166	molecular_function	nucleotide binding
H	0000502	cellular_component	proteasome complex
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0010498	biological_process	proteasomal protein catabolic process
H	0016887	molecular_function	ATP hydrolysis activity
H	0022623	cellular_component	proteasome-activating nucleotidase complex
H	0043335	biological_process	protein unfolding
I	0000166	molecular_function	nucleotide binding
I	0000502	cellular_component	proteasome complex
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0010498	biological_process	proteasomal protein catabolic process
I	0016887	molecular_function	ATP hydrolysis activity
I	0022623	cellular_component	proteasome-activating nucleotidase complex
I	0043335	biological_process	protein unfolding
J	0000166	molecular_function	nucleotide binding
J	0000502	cellular_component	proteasome complex
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0010498	biological_process	proteasomal protein catabolic process
J	0016887	molecular_function	ATP hydrolysis activity
J	0022623	cellular_component	proteasome-activating nucleotidase complex
J	0043335	biological_process	protein unfolding
K	0000166	molecular_function	nucleotide binding
K	0000502	cellular_component	proteasome complex
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0010498	biological_process	proteasomal protein catabolic process
K	0016887	molecular_function	ATP hydrolysis activity
K	0022623	cellular_component	proteasome-activating nucleotidase complex
K	0043335	biological_process	protein unfolding
L	0000166	molecular_function	nucleotide binding
L	0000502	cellular_component	proteasome complex
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0010498	biological_process	proteasomal protein catabolic process
L	0016887	molecular_function	ATP hydrolysis activity
L	0022623	cellular_component	proteasome-activating nucleotidase complex
L	0043335	biological_process	protein unfolding
M	0000166	molecular_function	nucleotide binding
M	0000502	cellular_component	proteasome complex
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0010498	biological_process	proteasomal protein catabolic process
M	0016887	molecular_function	ATP hydrolysis activity
M	0022623	cellular_component	proteasome-activating nucleotidase complex
M	0043335	biological_process	protein unfolding
a	0000502	cellular_component	proteasome complex
a	0004175	molecular_function	endopeptidase activity
a	0004298	molecular_function	threonine-type endopeptidase activity
a	0005515	molecular_function	protein binding
a	0005737	cellular_component	cytoplasm
a	0005839	cellular_component	proteasome core complex
a	0006511	biological_process	ubiquitin-dependent protein catabolic process
a	0010498	biological_process	proteasomal protein catabolic process
a	0019773	cellular_component	proteasome core complex, alpha-subunit complex
a	0051603	biological_process	proteolysis involved in protein catabolic process
b	0000502	cellular_component	proteasome complex
b	0004175	molecular_function	endopeptidase activity
b	0004298	molecular_function	threonine-type endopeptidase activity
b	0005515	molecular_function	protein binding
b	0005737	cellular_component	cytoplasm
b	0005839	cellular_component	proteasome core complex
b	0006511	biological_process	ubiquitin-dependent protein catabolic process
b	0010498	biological_process	proteasomal protein catabolic process
b	0019773	cellular_component	proteasome core complex, alpha-subunit complex
b	0051603	biological_process	proteolysis involved in protein catabolic process
c	0000502	cellular_component	proteasome complex
c	0004175	molecular_function	endopeptidase activity
c	0004298	molecular_function	threonine-type endopeptidase activity
c	0005515	molecular_function	protein binding
c	0005737	cellular_component	cytoplasm
c	0005839	cellular_component	proteasome core complex
c	0006511	biological_process	ubiquitin-dependent protein catabolic process
c	0010498	biological_process	proteasomal protein catabolic process
c	0019773	cellular_component	proteasome core complex, alpha-subunit complex
c	0051603	biological_process	proteolysis involved in protein catabolic process
d	0000502	cellular_component	proteasome complex
d	0004175	molecular_function	endopeptidase activity
d	0004298	molecular_function	threonine-type endopeptidase activity
d	0005515	molecular_function	protein binding
d	0005737	cellular_component	cytoplasm
d	0005839	cellular_component	proteasome core complex
d	0006511	biological_process	ubiquitin-dependent protein catabolic process
d	0010498	biological_process	proteasomal protein catabolic process
d	0019773	cellular_component	proteasome core complex, alpha-subunit complex
d	0051603	biological_process	proteolysis involved in protein catabolic process
e	0000502	cellular_component	proteasome complex
e	0004175	molecular_function	endopeptidase activity
e	0004298	molecular_function	threonine-type endopeptidase activity
e	0005515	molecular_function	protein binding
e	0005737	cellular_component	cytoplasm
e	0005839	cellular_component	proteasome core complex
e	0006511	biological_process	ubiquitin-dependent protein catabolic process
e	0010498	biological_process	proteasomal protein catabolic process
e	0019773	cellular_component	proteasome core complex, alpha-subunit complex
e	0051603	biological_process	proteolysis involved in protein catabolic process
f	0000502	cellular_component	proteasome complex
f	0004175	molecular_function	endopeptidase activity
f	0004298	molecular_function	threonine-type endopeptidase activity
f	0005515	molecular_function	protein binding
f	0005737	cellular_component	cytoplasm
f	0005839	cellular_component	proteasome core complex
f	0006511	biological_process	ubiquitin-dependent protein catabolic process
f	0010498	biological_process	proteasomal protein catabolic process
f	0019773	cellular_component	proteasome core complex, alpha-subunit complex
f	0051603	biological_process	proteolysis involved in protein catabolic process
g	0000502	cellular_component	proteasome complex
g	0004175	molecular_function	endopeptidase activity
g	0004298	molecular_function	threonine-type endopeptidase activity
g	0005515	molecular_function	protein binding
g	0005737	cellular_component	cytoplasm
g	0005839	cellular_component	proteasome core complex
g	0006511	biological_process	ubiquitin-dependent protein catabolic process
g	0010498	biological_process	proteasomal protein catabolic process
g	0019773	cellular_component	proteasome core complex, alpha-subunit complex
g	0051603	biological_process	proteolysis involved in protein catabolic process
h	0000502	cellular_component	proteasome complex
h	0004175	molecular_function	endopeptidase activity
h	0004298	molecular_function	threonine-type endopeptidase activity
h	0005515	molecular_function	protein binding
h	0005737	cellular_component	cytoplasm
h	0005839	cellular_component	proteasome core complex
h	0006508	biological_process	proteolysis
h	0008233	molecular_function	peptidase activity
h	0010498	biological_process	proteasomal protein catabolic process
h	0016787	molecular_function	hydrolase activity
h	0019774	cellular_component	proteasome core complex, beta-subunit complex
h	0051603	biological_process	proteolysis involved in protein catabolic process
i	0000502	cellular_component	proteasome complex
i	0004175	molecular_function	endopeptidase activity
i	0004298	molecular_function	threonine-type endopeptidase activity
i	0005515	molecular_function	protein binding
i	0005737	cellular_component	cytoplasm
i	0005839	cellular_component	proteasome core complex
i	0006508	biological_process	proteolysis
i	0008233	molecular_function	peptidase activity
i	0010498	biological_process	proteasomal protein catabolic process
i	0016787	molecular_function	hydrolase activity
i	0019774	cellular_component	proteasome core complex, beta-subunit complex
i	0051603	biological_process	proteolysis involved in protein catabolic process
j	0000502	cellular_component	proteasome complex
j	0004175	molecular_function	endopeptidase activity
j	0004298	molecular_function	threonine-type endopeptidase activity
j	0005515	molecular_function	protein binding
j	0005737	cellular_component	cytoplasm
j	0005839	cellular_component	proteasome core complex
j	0006508	biological_process	proteolysis
j	0008233	molecular_function	peptidase activity
j	0010498	biological_process	proteasomal protein catabolic process
j	0016787	molecular_function	hydrolase activity
j	0019774	cellular_component	proteasome core complex, beta-subunit complex
j	0051603	biological_process	proteolysis involved in protein catabolic process
k	0000502	cellular_component	proteasome complex
k	0004175	molecular_function	endopeptidase activity
k	0004298	molecular_function	threonine-type endopeptidase activity
k	0005515	molecular_function	protein binding
k	0005737	cellular_component	cytoplasm
k	0005839	cellular_component	proteasome core complex
k	0006508	biological_process	proteolysis
k	0008233	molecular_function	peptidase activity
k	0010498	biological_process	proteasomal protein catabolic process
k	0016787	molecular_function	hydrolase activity
k	0019774	cellular_component	proteasome core complex, beta-subunit complex
k	0051603	biological_process	proteolysis involved in protein catabolic process
l	0000502	cellular_component	proteasome complex
l	0004175	molecular_function	endopeptidase activity
l	0004298	molecular_function	threonine-type endopeptidase activity
l	0005515	molecular_function	protein binding
l	0005737	cellular_component	cytoplasm
l	0005839	cellular_component	proteasome core complex
l	0006508	biological_process	proteolysis
l	0008233	molecular_function	peptidase activity
l	0010498	biological_process	proteasomal protein catabolic process
l	0016787	molecular_function	hydrolase activity
l	0019774	cellular_component	proteasome core complex, beta-subunit complex
l	0051603	biological_process	proteolysis involved in protein catabolic process
m	0000502	cellular_component	proteasome complex
m	0004175	molecular_function	endopeptidase activity
m	0004298	molecular_function	threonine-type endopeptidase activity
m	0005515	molecular_function	protein binding
m	0005737	cellular_component	cytoplasm
m	0005839	cellular_component	proteasome core complex
m	0006508	biological_process	proteolysis
m	0008233	molecular_function	peptidase activity
m	0010498	biological_process	proteasomal protein catabolic process
m	0016787	molecular_function	hydrolase activity
m	0019774	cellular_component	proteasome core complex, beta-subunit complex
m	0051603	biological_process	proteolysis involved in protein catabolic process
n	0000502	cellular_component	proteasome complex
n	0004175	molecular_function	endopeptidase activity
n	0004298	molecular_function	threonine-type endopeptidase activity
n	0005515	molecular_function	protein binding
n	0005737	cellular_component	cytoplasm
n	0005839	cellular_component	proteasome core complex
n	0006508	biological_process	proteolysis
n	0008233	molecular_function	peptidase activity
n	0010498	biological_process	proteasomal protein catabolic process
n	0016787	molecular_function	hydrolase activity
n	0019774	cellular_component	proteasome core complex, beta-subunit complex
n	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue ATP H 401

Chain	Residue
H	ASP142
H	GLY348
H	ALA349
H	LYS352
H	MG402
I	LEU269
I	ARG299
I	ARG302
H	PRO184
H	GLY185
H	THR186
H	GLY187
H	LYS188
H	THR189
H	LEU190
H	GLU242

---

site_id	AC2
Number of Residues	2
Details	binding site for residue MG H 402

Chain	Residue
H	THR189
H	ATP401

---

site_id	AC3
Number of Residues	18
Details	binding site for residue ATP I 401

Chain	Residue
I	PRO184
I	GLY185
I	THR186
I	GLY187
I	LYS188
I	THR189
I	LEU190
I	ASN288
I	ILE320
I	HIS324
I	GLY348
I	ALA349
I	LYS352
I	MG402
J	ASP273
J	ALA296
J	ARG299
J	ARG302

---

site_id	AC4
Number of Residues	2
Details	binding site for residue MG I 402

Chain	Residue
I	THR189
I	ATP401

---

site_id	AC5
Number of Residues	17
Details	binding site for residue ATP L 401

Chain	Residue
L	ASP142
L	PRO184
L	GLY185
L	THR186
L	GLY187
L	LYS188
L	THR189
L	LEU190
L	GLU242
L	ASN288
L	HIS324
L	GLY348
L	ALA349
L	MG402
M	ALA296
M	ARG299
M	ARG302

---

site_id	AC6
Number of Residues	2
Details	binding site for residue MG L 402

Chain	Residue
L	THR189
L	ATP401

---

site_id	AC7
Number of Residues	19
Details	binding site for residue ATP M 401

Chain	Residue
H	LYS176
H	LEU269
H	ALA296
H	ARG299
H	ARG302
M	ILE143
M	GLY145
M	GLY185
M	THR186
M	GLY187
M	LYS188
M	THR189
M	LEU190
M	ASN288
M	HIS324
M	GLY348
M	ALA349
M	LYS352
M	MG402

---

site_id	AC8
Number of Residues	2
Details	binding site for residue MG M 402

Chain	Residue
M	THR189
M	ATP401

---

site_id	AC9
Number of Residues	17
Details	binding site for residue ADP J 401

Chain	Residue
J	ASP142
J	ILE143
J	PRO184
J	GLY185
J	THR186
J	GLY187
J	LYS188
J	THR189
J	LEU190
J	HIS324
J	GLY348
J	ALA349
J	LYS352
J	MG402
K	LYS176
K	ASP273
K	ARG299

---

site_id	AD1
Number of Residues	2
Details	binding site for residue MG J 402

Chain	Residue
J	THR189
J	ADP401

---

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdraiTvFSPdGRlfQVEYAreA

Chain	Residue	Details
A	TYR8-ALA30

---

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. VkVIgATNridiLDpAIl.R

Chain	Residue	Details
H	VAL281-ARG299

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGLvCkdGVVMATEkratmgnfiaskaak.KiyqiadrmamttaGsvGD

Chain	Residue	Details
7	VAL15-ASP62

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_02113","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Region: {"description":"Docks into pockets in the proteasome alpha-ring to cause gate opening","evidences":[{"source":"HAMAP-Rule","id":"MF_00553","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00553","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---