Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6HE8

PAN-proteasome in state 1

Functional Information from GO Data
ChainGOidnamespacecontents
10000502cellular_componentproteasome complex
10004175molecular_functionendopeptidase activity
10004298molecular_functionthreonine-type endopeptidase activity
10005515molecular_functionprotein binding
10005737cellular_componentcytoplasm
10005839cellular_componentproteasome core complex
10006508biological_processproteolysis
10010498biological_processproteasomal protein catabolic process
10019774cellular_componentproteasome core complex, beta-subunit complex
10051603biological_processproteolysis involved in protein catabolic process
20000502cellular_componentproteasome complex
20004175molecular_functionendopeptidase activity
20004298molecular_functionthreonine-type endopeptidase activity
20005515molecular_functionprotein binding
20005737cellular_componentcytoplasm
20005839cellular_componentproteasome core complex
20006508biological_processproteolysis
20010498biological_processproteasomal protein catabolic process
20019774cellular_componentproteasome core complex, beta-subunit complex
20051603biological_processproteolysis involved in protein catabolic process
30000502cellular_componentproteasome complex
30004175molecular_functionendopeptidase activity
30004298molecular_functionthreonine-type endopeptidase activity
30005515molecular_functionprotein binding
30005737cellular_componentcytoplasm
30005839cellular_componentproteasome core complex
30006508biological_processproteolysis
30010498biological_processproteasomal protein catabolic process
30019774cellular_componentproteasome core complex, beta-subunit complex
30051603biological_processproteolysis involved in protein catabolic process
40000502cellular_componentproteasome complex
40004175molecular_functionendopeptidase activity
40004298molecular_functionthreonine-type endopeptidase activity
40005515molecular_functionprotein binding
40005737cellular_componentcytoplasm
40005839cellular_componentproteasome core complex
40006508biological_processproteolysis
40010498biological_processproteasomal protein catabolic process
40019774cellular_componentproteasome core complex, beta-subunit complex
40051603biological_processproteolysis involved in protein catabolic process
50000502cellular_componentproteasome complex
50004175molecular_functionendopeptidase activity
50004298molecular_functionthreonine-type endopeptidase activity
50005515molecular_functionprotein binding
50005737cellular_componentcytoplasm
50005839cellular_componentproteasome core complex
50006508biological_processproteolysis
50010498biological_processproteasomal protein catabolic process
50019774cellular_componentproteasome core complex, beta-subunit complex
50051603biological_processproteolysis involved in protein catabolic process
60000502cellular_componentproteasome complex
60004175molecular_functionendopeptidase activity
60004298molecular_functionthreonine-type endopeptidase activity
60005515molecular_functionprotein binding
60005737cellular_componentcytoplasm
60005839cellular_componentproteasome core complex
60006508biological_processproteolysis
60010498biological_processproteasomal protein catabolic process
60019774cellular_componentproteasome core complex, beta-subunit complex
60051603biological_processproteolysis involved in protein catabolic process
70000502cellular_componentproteasome complex
70004175molecular_functionendopeptidase activity
70004298molecular_functionthreonine-type endopeptidase activity
70005515molecular_functionprotein binding
70005737cellular_componentcytoplasm
70005839cellular_componentproteasome core complex
70006508biological_processproteolysis
70010498biological_processproteasomal protein catabolic process
70019774cellular_componentproteasome core complex, beta-subunit complex
70051603biological_processproteolysis involved in protein catabolic process
a0000502cellular_componentproteasome complex
a0004175molecular_functionendopeptidase activity
a0004298molecular_functionthreonine-type endopeptidase activity
a0005515molecular_functionprotein binding
a0005737cellular_componentcytoplasm
a0005829cellular_componentcytosol
a0005839cellular_componentproteasome core complex
a0006511biological_processubiquitin-dependent protein catabolic process
a0010498biological_processproteasomal protein catabolic process
a0019773cellular_componentproteasome core complex, alpha-subunit complex
a0019774cellular_componentproteasome core complex, beta-subunit complex
a0051603biological_processproteolysis involved in protein catabolic process
A0000502cellular_componentproteasome complex
A0004175molecular_functionendopeptidase activity
A0004298molecular_functionthreonine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005839cellular_componentproteasome core complex
A0006511biological_processubiquitin-dependent protein catabolic process
A0010498biological_processproteasomal protein catabolic process
A0019773cellular_componentproteasome core complex, alpha-subunit complex
A0019774cellular_componentproteasome core complex, beta-subunit complex
A0051603biological_processproteolysis involved in protein catabolic process
b0000502cellular_componentproteasome complex
b0004175molecular_functionendopeptidase activity
b0004298molecular_functionthreonine-type endopeptidase activity
b0005515molecular_functionprotein binding
b0005737cellular_componentcytoplasm
b0005829cellular_componentcytosol
b0005839cellular_componentproteasome core complex
b0006511biological_processubiquitin-dependent protein catabolic process
b0010498biological_processproteasomal protein catabolic process
b0019773cellular_componentproteasome core complex, alpha-subunit complex
b0019774cellular_componentproteasome core complex, beta-subunit complex
b0051603biological_processproteolysis involved in protein catabolic process
B0000502cellular_componentproteasome complex
B0004175molecular_functionendopeptidase activity
B0004298molecular_functionthreonine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005839cellular_componentproteasome core complex
B0006511biological_processubiquitin-dependent protein catabolic process
B0010498biological_processproteasomal protein catabolic process
B0019773cellular_componentproteasome core complex, alpha-subunit complex
B0019774cellular_componentproteasome core complex, beta-subunit complex
B0051603biological_processproteolysis involved in protein catabolic process
c0000502cellular_componentproteasome complex
c0004175molecular_functionendopeptidase activity
c0004298molecular_functionthreonine-type endopeptidase activity
c0005515molecular_functionprotein binding
c0005737cellular_componentcytoplasm
c0005829cellular_componentcytosol
c0005839cellular_componentproteasome core complex
c0006511biological_processubiquitin-dependent protein catabolic process
c0010498biological_processproteasomal protein catabolic process
c0019773cellular_componentproteasome core complex, alpha-subunit complex
c0019774cellular_componentproteasome core complex, beta-subunit complex
c0051603biological_processproteolysis involved in protein catabolic process
C0000502cellular_componentproteasome complex
C0004175molecular_functionendopeptidase activity
C0004298molecular_functionthreonine-type endopeptidase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005839cellular_componentproteasome core complex
C0006511biological_processubiquitin-dependent protein catabolic process
C0010498biological_processproteasomal protein catabolic process
C0019773cellular_componentproteasome core complex, alpha-subunit complex
C0019774cellular_componentproteasome core complex, beta-subunit complex
C0051603biological_processproteolysis involved in protein catabolic process
d0000502cellular_componentproteasome complex
d0004175molecular_functionendopeptidase activity
d0004298molecular_functionthreonine-type endopeptidase activity
d0005515molecular_functionprotein binding
d0005737cellular_componentcytoplasm
d0005829cellular_componentcytosol
d0005839cellular_componentproteasome core complex
d0006511biological_processubiquitin-dependent protein catabolic process
d0010498biological_processproteasomal protein catabolic process
d0019773cellular_componentproteasome core complex, alpha-subunit complex
d0019774cellular_componentproteasome core complex, beta-subunit complex
d0051603biological_processproteolysis involved in protein catabolic process
D0000502cellular_componentproteasome complex
D0004175molecular_functionendopeptidase activity
D0004298molecular_functionthreonine-type endopeptidase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005839cellular_componentproteasome core complex
D0006511biological_processubiquitin-dependent protein catabolic process
D0010498biological_processproteasomal protein catabolic process
D0019773cellular_componentproteasome core complex, alpha-subunit complex
D0019774cellular_componentproteasome core complex, beta-subunit complex
D0051603biological_processproteolysis involved in protein catabolic process
e0000502cellular_componentproteasome complex
e0004175molecular_functionendopeptidase activity
e0004298molecular_functionthreonine-type endopeptidase activity
e0005515molecular_functionprotein binding
e0005737cellular_componentcytoplasm
e0005829cellular_componentcytosol
e0005839cellular_componentproteasome core complex
e0006511biological_processubiquitin-dependent protein catabolic process
e0010498biological_processproteasomal protein catabolic process
e0019773cellular_componentproteasome core complex, alpha-subunit complex
e0019774cellular_componentproteasome core complex, beta-subunit complex
e0051603biological_processproteolysis involved in protein catabolic process
E0000502cellular_componentproteasome complex
E0004175molecular_functionendopeptidase activity
E0004298molecular_functionthreonine-type endopeptidase activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005839cellular_componentproteasome core complex
E0006511biological_processubiquitin-dependent protein catabolic process
E0010498biological_processproteasomal protein catabolic process
E0019773cellular_componentproteasome core complex, alpha-subunit complex
E0019774cellular_componentproteasome core complex, beta-subunit complex
E0051603biological_processproteolysis involved in protein catabolic process
f0000502cellular_componentproteasome complex
f0004175molecular_functionendopeptidase activity
f0004298molecular_functionthreonine-type endopeptidase activity
f0005515molecular_functionprotein binding
f0005737cellular_componentcytoplasm
f0005829cellular_componentcytosol
f0005839cellular_componentproteasome core complex
f0006511biological_processubiquitin-dependent protein catabolic process
f0010498biological_processproteasomal protein catabolic process
f0019773cellular_componentproteasome core complex, alpha-subunit complex
f0019774cellular_componentproteasome core complex, beta-subunit complex
f0051603biological_processproteolysis involved in protein catabolic process
F0000502cellular_componentproteasome complex
F0004175molecular_functionendopeptidase activity
F0004298molecular_functionthreonine-type endopeptidase activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005839cellular_componentproteasome core complex
F0006511biological_processubiquitin-dependent protein catabolic process
F0010498biological_processproteasomal protein catabolic process
F0019773cellular_componentproteasome core complex, alpha-subunit complex
F0019774cellular_componentproteasome core complex, beta-subunit complex
F0051603biological_processproteolysis involved in protein catabolic process
g0000502cellular_componentproteasome complex
g0004175molecular_functionendopeptidase activity
g0004298molecular_functionthreonine-type endopeptidase activity
g0005515molecular_functionprotein binding
g0005737cellular_componentcytoplasm
g0005829cellular_componentcytosol
g0005839cellular_componentproteasome core complex
g0006511biological_processubiquitin-dependent protein catabolic process
g0010498biological_processproteasomal protein catabolic process
g0019773cellular_componentproteasome core complex, alpha-subunit complex
g0019774cellular_componentproteasome core complex, beta-subunit complex
g0051603biological_processproteolysis involved in protein catabolic process
G0000502cellular_componentproteasome complex
G0004175molecular_functionendopeptidase activity
G0004298molecular_functionthreonine-type endopeptidase activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005839cellular_componentproteasome core complex
G0006511biological_processubiquitin-dependent protein catabolic process
G0010498biological_processproteasomal protein catabolic process
G0019773cellular_componentproteasome core complex, alpha-subunit complex
G0019774cellular_componentproteasome core complex, beta-subunit complex
G0051603biological_processproteolysis involved in protein catabolic process
h0000502cellular_componentproteasome complex
h0004175molecular_functionendopeptidase activity
h0004298molecular_functionthreonine-type endopeptidase activity
h0005515molecular_functionprotein binding
h0005737cellular_componentcytoplasm
h0005839cellular_componentproteasome core complex
h0006508biological_processproteolysis
h0010498biological_processproteasomal protein catabolic process
h0019774cellular_componentproteasome core complex, beta-subunit complex
h0051603biological_processproteolysis involved in protein catabolic process
H0000502cellular_componentproteasome complex
H0005524molecular_functionATP binding
H0005737cellular_componentcytoplasm
H0008540cellular_componentproteasome regulatory particle, base subcomplex
H0010498biological_processproteasomal protein catabolic process
H0016887molecular_functionATP hydrolysis activity
H0022623cellular_componentproteasome-activating nucleotidase complex
H0031597cellular_componentcytosolic proteasome complex
H0036402molecular_functionproteasome-activating activity
H0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
H0043335biological_processprotein unfolding
H0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
H1901800biological_processpositive regulation of proteasomal protein catabolic process
i0000502cellular_componentproteasome complex
i0004175molecular_functionendopeptidase activity
i0004298molecular_functionthreonine-type endopeptidase activity
i0005515molecular_functionprotein binding
i0005737cellular_componentcytoplasm
i0005839cellular_componentproteasome core complex
i0006508biological_processproteolysis
i0010498biological_processproteasomal protein catabolic process
i0019774cellular_componentproteasome core complex, beta-subunit complex
i0051603biological_processproteolysis involved in protein catabolic process
I0000502cellular_componentproteasome complex
I0005524molecular_functionATP binding
I0005737cellular_componentcytoplasm
I0008540cellular_componentproteasome regulatory particle, base subcomplex
I0010498biological_processproteasomal protein catabolic process
I0016887molecular_functionATP hydrolysis activity
I0022623cellular_componentproteasome-activating nucleotidase complex
I0031597cellular_componentcytosolic proteasome complex
I0036402molecular_functionproteasome-activating activity
I0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
I0043335biological_processprotein unfolding
I0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
I1901800biological_processpositive regulation of proteasomal protein catabolic process
j0000502cellular_componentproteasome complex
j0004175molecular_functionendopeptidase activity
j0004298molecular_functionthreonine-type endopeptidase activity
j0005515molecular_functionprotein binding
j0005737cellular_componentcytoplasm
j0005839cellular_componentproteasome core complex
j0006508biological_processproteolysis
j0010498biological_processproteasomal protein catabolic process
j0019774cellular_componentproteasome core complex, beta-subunit complex
j0051603biological_processproteolysis involved in protein catabolic process
J0000502cellular_componentproteasome complex
J0005524molecular_functionATP binding
J0005737cellular_componentcytoplasm
J0008540cellular_componentproteasome regulatory particle, base subcomplex
J0010498biological_processproteasomal protein catabolic process
J0016887molecular_functionATP hydrolysis activity
J0022623cellular_componentproteasome-activating nucleotidase complex
J0031597cellular_componentcytosolic proteasome complex
J0036402molecular_functionproteasome-activating activity
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0043335biological_processprotein unfolding
J0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
J1901800biological_processpositive regulation of proteasomal protein catabolic process
k0000502cellular_componentproteasome complex
k0004175molecular_functionendopeptidase activity
k0004298molecular_functionthreonine-type endopeptidase activity
k0005515molecular_functionprotein binding
k0005737cellular_componentcytoplasm
k0005839cellular_componentproteasome core complex
k0006508biological_processproteolysis
k0010498biological_processproteasomal protein catabolic process
k0019774cellular_componentproteasome core complex, beta-subunit complex
k0051603biological_processproteolysis involved in protein catabolic process
K0000502cellular_componentproteasome complex
K0005524molecular_functionATP binding
K0005737cellular_componentcytoplasm
K0008540cellular_componentproteasome regulatory particle, base subcomplex
K0010498biological_processproteasomal protein catabolic process
K0016887molecular_functionATP hydrolysis activity
K0022623cellular_componentproteasome-activating nucleotidase complex
K0031597cellular_componentcytosolic proteasome complex
K0036402molecular_functionproteasome-activating activity
K0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
K0043335biological_processprotein unfolding
K0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
K1901800biological_processpositive regulation of proteasomal protein catabolic process
l0000502cellular_componentproteasome complex
l0004175molecular_functionendopeptidase activity
l0004298molecular_functionthreonine-type endopeptidase activity
l0005515molecular_functionprotein binding
l0005737cellular_componentcytoplasm
l0005839cellular_componentproteasome core complex
l0006508biological_processproteolysis
l0010498biological_processproteasomal protein catabolic process
l0019774cellular_componentproteasome core complex, beta-subunit complex
l0051603biological_processproteolysis involved in protein catabolic process
L0000502cellular_componentproteasome complex
L0005524molecular_functionATP binding
L0005737cellular_componentcytoplasm
L0008540cellular_componentproteasome regulatory particle, base subcomplex
L0010498biological_processproteasomal protein catabolic process
L0016887molecular_functionATP hydrolysis activity
L0022623cellular_componentproteasome-activating nucleotidase complex
L0031597cellular_componentcytosolic proteasome complex
L0036402molecular_functionproteasome-activating activity
L0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
L0043335biological_processprotein unfolding
L0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
L1901800biological_processpositive regulation of proteasomal protein catabolic process
m0000502cellular_componentproteasome complex
m0004175molecular_functionendopeptidase activity
m0004298molecular_functionthreonine-type endopeptidase activity
m0005515molecular_functionprotein binding
m0005737cellular_componentcytoplasm
m0005839cellular_componentproteasome core complex
m0006508biological_processproteolysis
m0010498biological_processproteasomal protein catabolic process
m0019774cellular_componentproteasome core complex, beta-subunit complex
m0051603biological_processproteolysis involved in protein catabolic process
M0000502cellular_componentproteasome complex
M0005524molecular_functionATP binding
M0005737cellular_componentcytoplasm
M0008540cellular_componentproteasome regulatory particle, base subcomplex
M0010498biological_processproteasomal protein catabolic process
M0016887molecular_functionATP hydrolysis activity
M0022623cellular_componentproteasome-activating nucleotidase complex
M0031597cellular_componentcytosolic proteasome complex
M0036402molecular_functionproteasome-activating activity
M0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
M0043335biological_processprotein unfolding
M0045899biological_processpositive regulation of RNA polymerase II transcription preinitiation complex assembly
M1901800biological_processpositive regulation of proteasomal protein catabolic process
n0000502cellular_componentproteasome complex
n0004175molecular_functionendopeptidase activity
n0004298molecular_functionthreonine-type endopeptidase activity
n0005515molecular_functionprotein binding
n0005737cellular_componentcytoplasm
n0005839cellular_componentproteasome core complex
n0006508biological_processproteolysis
n0010498biological_processproteasomal protein catabolic process
n0019774cellular_componentproteasome core complex, beta-subunit complex
n0051603biological_processproteolysis involved in protein catabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue ATP I 401
ChainResidue
IILE143
IHIS324
IALA349
IMG402
JLYS176
JARG299
JARG302
IGLY185
ITHR186
IGLY187
ILYS188
ITHR189
ILEU190
IASN288
IILE320

site_idAC2
Number of Residues2
Detailsbinding site for residue MG I 402
ChainResidue
ITHR189
IATP401

site_idAC3
Number of Residues18
Detailsbinding site for residue ATP K 401
ChainResidue
KPRO183
KPRO184
KGLY185
KTHR186
KGLY187
KLYS188
KTHR189
KLEU190
KILE320
KHIS324
KGLY348
KALA349
KLYS352
KMG402
LLEU269
LASP273
LARG299
LARG302

site_idAC4
Number of Residues2
Detailsbinding site for residue MG K 402
ChainResidue
KTHR189
KATP401

site_idAC5
Number of Residues17
Detailsbinding site for residue ATP L 401
ChainResidue
LPRO184
LGLY185
LTHR186
LGLY187
LLYS188
LTHR189
LLEU190
LGLU242
LASN288
LILE320
LHIS324
LGLY348
LLYS352
LMG402
MASP273
MARG299
MARG302

site_idAC6
Number of Residues2
Detailsbinding site for residue MG L 402
ChainResidue
LTHR189
LATP401

site_idAC7
Number of Residues13
Detailsbinding site for residue ADP M 401
ChainResidue
HARG299
MILE143
MGLY185
MTHR186
MGLY187
MLYS188
MTHR189
MLEU190
MASP241
MHIS324
MGLY348
MALA349
MMG402

site_idAC8
Number of Residues2
Detailsbinding site for residue MG M 402
ChainResidue
MTHR189
MADP401

site_idAC9
Number of Residues15
Detailsbinding site for residue ATP J 401
ChainResidue
JPRO184
JGLY185
JTHR186
JGLY187
JLYS188
JTHR189
JLEU190
JASN288
JHIS324
JALA349
JMG402
KLEU269
KALA296
KARG299
KARG302

site_idAD1
Number of Residues2
Detailsbinding site for residue MG J 402
ChainResidue
JTHR189
JATP401

Functional Information from PROSITE/UniProt
site_idPS00388
Number of Residues23
DetailsPROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdraiTvFSPdGRlfQVEYAreA
ChainResidueDetails
ATYR8-ALA30

site_idPS00674
Number of Residues19
DetailsAAA AAA-protein family signature. VkVIgATNridiLDpAIl.R
ChainResidueDetails
HVAL281-ARG299

site_idPS00854
Number of Residues48
DetailsPROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGLvCkdGVVMATEkratmgnfiaskaak.KiyqiadrmamttaGsvGD
ChainResidueDetails
7VAL15-ASP62

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00553
ChainResidueDetails
HGLY185
MHIS324
JGLY185
JHIS324
7THR12
nTHR12
HHIS324
IGLY185
IHIS324
KGLY185
KHIS324
LGLY185
LHIS324
MGLY185

219140

PDB entries from 2024-05-01

PDB statisticsPDBj update infoContact PDBjnumon