6HE5

20S core particle of PAN-proteasomes

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0004175	molecular_function	endopeptidase activity
1	0004298	molecular_function	threonine-type endopeptidase activity
1	0005515	molecular_function	protein binding
1	0005737	cellular_component	cytoplasm
1	0005839	cellular_component	proteasome core complex
1	0010498	biological_process	proteasomal protein catabolic process
1	0019774	cellular_component	proteasome core complex, beta-subunit complex
1	0030163	biological_process	protein catabolic process
2	0004175	molecular_function	endopeptidase activity
2	0004298	molecular_function	threonine-type endopeptidase activity
2	0005515	molecular_function	protein binding
2	0005737	cellular_component	cytoplasm
2	0005839	cellular_component	proteasome core complex
2	0010498	biological_process	proteasomal protein catabolic process
2	0019774	cellular_component	proteasome core complex, beta-subunit complex
2	0030163	biological_process	protein catabolic process
3	0004175	molecular_function	endopeptidase activity
3	0004298	molecular_function	threonine-type endopeptidase activity
3	0005515	molecular_function	protein binding
3	0005737	cellular_component	cytoplasm
3	0005839	cellular_component	proteasome core complex
3	0010498	biological_process	proteasomal protein catabolic process
3	0019774	cellular_component	proteasome core complex, beta-subunit complex
3	0030163	biological_process	protein catabolic process
4	0004175	molecular_function	endopeptidase activity
4	0004298	molecular_function	threonine-type endopeptidase activity
4	0005515	molecular_function	protein binding
4	0005737	cellular_component	cytoplasm
4	0005839	cellular_component	proteasome core complex
4	0010498	biological_process	proteasomal protein catabolic process
4	0019774	cellular_component	proteasome core complex, beta-subunit complex
4	0030163	biological_process	protein catabolic process
5	0004175	molecular_function	endopeptidase activity
5	0004298	molecular_function	threonine-type endopeptidase activity
5	0005515	molecular_function	protein binding
5	0005737	cellular_component	cytoplasm
5	0005839	cellular_component	proteasome core complex
5	0010498	biological_process	proteasomal protein catabolic process
5	0019774	cellular_component	proteasome core complex, beta-subunit complex
5	0030163	biological_process	protein catabolic process
6	0004175	molecular_function	endopeptidase activity
6	0004298	molecular_function	threonine-type endopeptidase activity
6	0005515	molecular_function	protein binding
6	0005737	cellular_component	cytoplasm
6	0005839	cellular_component	proteasome core complex
6	0010498	biological_process	proteasomal protein catabolic process
6	0019774	cellular_component	proteasome core complex, beta-subunit complex
6	0030163	biological_process	protein catabolic process
7	0004175	molecular_function	endopeptidase activity
7	0004298	molecular_function	threonine-type endopeptidase activity
7	0005515	molecular_function	protein binding
7	0005737	cellular_component	cytoplasm
7	0005839	cellular_component	proteasome core complex
7	0010498	biological_process	proteasomal protein catabolic process
7	0019774	cellular_component	proteasome core complex, beta-subunit complex
7	0030163	biological_process	protein catabolic process
A	0004175	molecular_function	endopeptidase activity
A	0004298	molecular_function	threonine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0010498	biological_process	proteasomal protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0030163	biological_process	protein catabolic process
B	0004175	molecular_function	endopeptidase activity
B	0004298	molecular_function	threonine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0010498	biological_process	proteasomal protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0030163	biological_process	protein catabolic process
C	0004175	molecular_function	endopeptidase activity
C	0004298	molecular_function	threonine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0010498	biological_process	proteasomal protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0030163	biological_process	protein catabolic process
D	0004175	molecular_function	endopeptidase activity
D	0004298	molecular_function	threonine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0010498	biological_process	proteasomal protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0030163	biological_process	protein catabolic process
E	0004175	molecular_function	endopeptidase activity
E	0004298	molecular_function	threonine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0010498	biological_process	proteasomal protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0030163	biological_process	protein catabolic process
F	0004175	molecular_function	endopeptidase activity
F	0004298	molecular_function	threonine-type endopeptidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0010498	biological_process	proteasomal protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0030163	biological_process	protein catabolic process
G	0004175	molecular_function	endopeptidase activity
G	0004298	molecular_function	threonine-type endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0010498	biological_process	proteasomal protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0030163	biological_process	protein catabolic process
H	0000502	cellular_component	proteasome complex
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0010498	biological_process	proteasomal protein catabolic process
H	0016887	molecular_function	ATP hydrolysis activity
H	0022623	cellular_component	proteasome-activating nucleotidase complex
H	0043335	biological_process	protein unfolding
I	0000502	cellular_component	proteasome complex
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0010498	biological_process	proteasomal protein catabolic process
I	0016887	molecular_function	ATP hydrolysis activity
I	0022623	cellular_component	proteasome-activating nucleotidase complex
I	0043335	biological_process	protein unfolding
J	0000502	cellular_component	proteasome complex
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0010498	biological_process	proteasomal protein catabolic process
J	0016887	molecular_function	ATP hydrolysis activity
J	0022623	cellular_component	proteasome-activating nucleotidase complex
J	0043335	biological_process	protein unfolding
K	0000502	cellular_component	proteasome complex
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0010498	biological_process	proteasomal protein catabolic process
K	0016887	molecular_function	ATP hydrolysis activity
K	0022623	cellular_component	proteasome-activating nucleotidase complex
K	0043335	biological_process	protein unfolding
L	0000502	cellular_component	proteasome complex
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0010498	biological_process	proteasomal protein catabolic process
L	0016887	molecular_function	ATP hydrolysis activity
L	0022623	cellular_component	proteasome-activating nucleotidase complex
L	0043335	biological_process	protein unfolding
M	0000502	cellular_component	proteasome complex
M	0005524	molecular_function	ATP binding
M	0005737	cellular_component	cytoplasm
M	0010498	biological_process	proteasomal protein catabolic process
M	0016887	molecular_function	ATP hydrolysis activity
M	0022623	cellular_component	proteasome-activating nucleotidase complex
M	0043335	biological_process	protein unfolding

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdraiTvFSPdGRlfQVEYAreA

Chain	Residue	Details
A	TYR8-ALA30

---

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. VkVIgATNridiLDpAIl.R

Chain	Residue	Details
H	VAL281-ARG299

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGLvCkdGVVMATEkratmgnfiaskaak.KiyqiadrmamttaGsvGD

Chain	Residue	Details
1	VAL15-ASP62

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_02113","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Region: {"description":"Docks into pockets in the proteasome alpha-ring to cause gate opening","evidences":[{"source":"HAMAP-Rule","id":"MF_00553","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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