6HCY

human STEAP4 bound to NADP, FAD, heme and Fe(III)-NTA.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0005654	cellular_component	nucleoplasm
A	0005768	cellular_component	endosome
A	0005794	cellular_component	Golgi apparatus
A	0005886	cellular_component	plasma membrane
A	0006826	biological_process	iron ion transport
A	0008823	molecular_function	cupric reductase (NADH) activity
A	0009055	molecular_function	electron transfer activity
A	0010008	cellular_component	endosome membrane
A	0015677	biological_process	copper ion import
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0020037	molecular_function	heme binding
A	0031901	cellular_component	early endosome membrane
A	0033212	biological_process	iron import into cell
A	0045444	biological_process	fat cell differentiation
A	0046872	molecular_function	metal ion binding
A	0052851	molecular_function	ferric-chelate reductase (NADPH) activity
A	0070062	cellular_component	extracellular exosome
A	0070207	biological_process	protein homotrimerization
A	0071949	molecular_function	FAD binding
B	0000139	cellular_component	Golgi membrane
B	0005654	cellular_component	nucleoplasm
B	0005768	cellular_component	endosome
B	0005794	cellular_component	Golgi apparatus
B	0005886	cellular_component	plasma membrane
B	0006826	biological_process	iron ion transport
B	0008823	molecular_function	cupric reductase (NADH) activity
B	0009055	molecular_function	electron transfer activity
B	0010008	cellular_component	endosome membrane
B	0015677	biological_process	copper ion import
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0020037	molecular_function	heme binding
B	0031901	cellular_component	early endosome membrane
B	0033212	biological_process	iron import into cell
B	0045444	biological_process	fat cell differentiation
B	0046872	molecular_function	metal ion binding
B	0052851	molecular_function	ferric-chelate reductase (NADPH) activity
B	0070062	cellular_component	extracellular exosome
B	0070207	biological_process	protein homotrimerization
B	0071949	molecular_function	FAD binding
C	0000139	cellular_component	Golgi membrane
C	0005654	cellular_component	nucleoplasm
C	0005768	cellular_component	endosome
C	0005794	cellular_component	Golgi apparatus
C	0005886	cellular_component	plasma membrane
C	0006826	biological_process	iron ion transport
C	0008823	molecular_function	cupric reductase (NADH) activity
C	0009055	molecular_function	electron transfer activity
C	0010008	cellular_component	endosome membrane
C	0015677	biological_process	copper ion import
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
C	0031901	cellular_component	early endosome membrane
C	0033212	biological_process	iron import into cell
C	0045444	biological_process	fat cell differentiation
C	0046872	molecular_function	metal ion binding
C	0052851	molecular_function	ferric-chelate reductase (NADPH) activity
C	0070062	cellular_component	extracellular exosome
C	0070207	biological_process	protein homotrimerization
C	0071949	molecular_function	FAD binding

Functional Information from PROSITE/UniProt

site_id	PS00024
Number of Residues	15
Details	HEMOPEXIN Hemopexin domain signature. LFpmWrf.PfYLSAVL

Chain	Residue	Details
C	LEU196-LEU210

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	366
Details	TRANSMEM: Helical => ECO:0000269|PubMed:30337524

Chain	Residue	Details
C	PHE202-ILE224
A	ALA342-LEU362
A	PHE381-TYR401
A	ALA419-MET439
B	PHE202-ILE224
B	PHE236-ALA256
B	LEU293-ILE313
B	ALA342-LEU362
B	PHE381-TYR401
B	ALA419-MET439
C	PHE236-ALA256
C	LEU293-ILE313
C	ALA342-LEU362
C	PHE381-TYR401
C	ALA419-MET439
A	PHE202-ILE224
A	PHE236-ALA256
A	LEU293-ILE313

---

site_id	SWS_FT_FI2
Number of Residues	33
Details	BINDING: BINDING => ECO:0000269|PubMed:30337524, ECO:0007744|PDB:6HCY

Chain	Residue	Details
C	THR27
C	SER366
C	GLN383
A	THR27
A	SER49
A	TYR67
A	ILE81
A	ASN106
A	TRP140
A	ASP148
A	GLN269
C	SER49
A	ARG290
A	SER366
A	GLN383
B	THR27
B	SER49
B	TYR67
B	ILE81
B	ASN106
B	TRP140
B	ASP148
C	TYR67
B	GLN269
B	ARG290
B	SER366
B	GLN383
C	ILE81
C	ASN106
C	TRP140
C	ASP148
C	GLN269
C	ARG290

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q4V8K1

Chain	Residue	Details
C	ALA139
C	ARG171
A	ALA139
A	ARG171
B	ALA139
B	ARG171

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q658P3

Chain	Residue	Details
C	TYR217
C	TYR307
A	TYR217
A	TYR307
B	TYR217
B	TYR307

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	BINDING: axial binding residue => ECO:0000269|PubMed:30337524, ECO:0007744|PDB:6HCY

Chain	Residue	Details
C	HIS304
C	HIS397
A	HIS304
A	HIS397
B	HIS304
B	HIS397

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:30337524, ECO:0007744|PDB:6HCY

Chain	Residue	Details
C	ASN323
A	ASN323
B	ASN323

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