6HCY
human STEAP4 bound to NADP, FAD, heme and Fe(III)-NTA.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005768 | cellular_component | endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006826 | biological_process | iron ion transport |
| A | 0008823 | molecular_function | cupric reductase (NADH) activity |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0015677 | biological_process | copper ion import |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0020037 | molecular_function | heme binding |
| A | 0031901 | cellular_component | early endosome membrane |
| A | 0033212 | biological_process | iron import into cell |
| A | 0045444 | biological_process | fat cell differentiation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052851 | molecular_function | ferric-chelate reductase (NADPH) activity |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070207 | biological_process | protein homotrimerization |
| A | 0071949 | molecular_function | FAD binding |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005768 | cellular_component | endosome |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006826 | biological_process | iron ion transport |
| B | 0008823 | molecular_function | cupric reductase (NADH) activity |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0010008 | cellular_component | endosome membrane |
| B | 0015677 | biological_process | copper ion import |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0020037 | molecular_function | heme binding |
| B | 0031901 | cellular_component | early endosome membrane |
| B | 0033212 | biological_process | iron import into cell |
| B | 0045444 | biological_process | fat cell differentiation |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052851 | molecular_function | ferric-chelate reductase (NADPH) activity |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070207 | biological_process | protein homotrimerization |
| B | 0071949 | molecular_function | FAD binding |
| C | 0000139 | cellular_component | Golgi membrane |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005768 | cellular_component | endosome |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006826 | biological_process | iron ion transport |
| C | 0008823 | molecular_function | cupric reductase (NADH) activity |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0010008 | cellular_component | endosome membrane |
| C | 0015677 | biological_process | copper ion import |
| C | 0016020 | cellular_component | membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0020037 | molecular_function | heme binding |
| C | 0031901 | cellular_component | early endosome membrane |
| C | 0033212 | biological_process | iron import into cell |
| C | 0045444 | biological_process | fat cell differentiation |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0052851 | molecular_function | ferric-chelate reductase (NADPH) activity |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0070207 | biological_process | protein homotrimerization |
| C | 0071949 | molecular_function | FAD binding |
Functional Information from PROSITE/UniProt
| site_id | PS00024 |
| Number of Residues | 15 |
| Details | HEMOPEXIN Hemopexin domain signature. LFpmWrf.PfYLSAVL |
| Chain | Residue | Details |
| C | LEU196-LEU210 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 366 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30337524","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 444 |
| Details | Domain: {"description":"Ferric oxidoreductase","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 48 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30337524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6HCY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q4V8K1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q658P3","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"30337524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6HCY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30337524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6HCY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
