6HCY

human STEAP4 bound to NADP, FAD, heme and Fe(III)-NTA.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0005768	cellular_component	endosome
A	0005886	cellular_component	plasma membrane
A	0008823	molecular_function	cupric reductase (NADH) activity
A	0009055	molecular_function	electron transfer activity
A	0010008	cellular_component	endosome membrane
A	0015677	biological_process	copper ion import
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0031901	cellular_component	early endosome membrane
A	0045444	biological_process	fat cell differentiation
A	0052851	molecular_function	ferric-chelate reductase (NADPH) activity
A	0070062	cellular_component	extracellular exosome
A	0070207	biological_process	protein homotrimerization
A	0071949	molecular_function	FAD binding
A	7770068	molecular_function	ferric iron reductase activity
B	0000139	cellular_component	Golgi membrane
B	0005768	cellular_component	endosome
B	0005886	cellular_component	plasma membrane
B	0008823	molecular_function	cupric reductase (NADH) activity
B	0009055	molecular_function	electron transfer activity
B	0010008	cellular_component	endosome membrane
B	0015677	biological_process	copper ion import
B	0016020	cellular_component	membrane
B	0020037	molecular_function	heme binding
B	0031901	cellular_component	early endosome membrane
B	0045444	biological_process	fat cell differentiation
B	0052851	molecular_function	ferric-chelate reductase (NADPH) activity
B	0070062	cellular_component	extracellular exosome
B	0070207	biological_process	protein homotrimerization
B	0071949	molecular_function	FAD binding
B	7770068	molecular_function	ferric iron reductase activity
C	0000139	cellular_component	Golgi membrane
C	0005768	cellular_component	endosome
C	0005886	cellular_component	plasma membrane
C	0008823	molecular_function	cupric reductase (NADH) activity
C	0009055	molecular_function	electron transfer activity
C	0010008	cellular_component	endosome membrane
C	0015677	biological_process	copper ion import
C	0016020	cellular_component	membrane
C	0020037	molecular_function	heme binding
C	0031901	cellular_component	early endosome membrane
C	0045444	biological_process	fat cell differentiation
C	0052851	molecular_function	ferric-chelate reductase (NADPH) activity
C	0070062	cellular_component	extracellular exosome
C	0070207	biological_process	protein homotrimerization
C	0071949	molecular_function	FAD binding
C	7770068	molecular_function	ferric iron reductase activity

Functional Information from PROSITE/UniProt

site_id	PS00024
Number of Residues	15
Details	HEMOPEXIN Hemopexin domain signature. LFpmWrf.PfYLSAVL

Chain	Residue	Details
C	LEU196-LEU210

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	366
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30337524","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	444
Details	Domain: {"description":"Ferric oxidoreductase","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30337524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6HCY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q4V8K1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q658P3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	6
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"30337524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6HCY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30337524","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6HCY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---