6HCB
STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM01 AT 1.9 A RESOLUTION.
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 301 |
| Chain | Residue |
| A | ARG31 |
| A | HOH433 |
| A | HOH473 |
| A | HOH477 |
| B | LYS183 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | ARG148 |
| A | HOH406 |
| A | HOH410 |
| A | HOH482 |
| A | ALA63 |
| A | ASP139 |
| A | SER140 |
| A | LYS144 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | GLU97 |
| A | ASP101 |
| A | PHE102 |
| A | HOH448 |
| A | HOH528 |
| B | LYS104 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 304 |
| Chain | Residue |
| A | HIS46 |
| A | GLN244 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 305 |
| Chain | Residue |
| A | LYS249 |
| B | ILE152 |
| B | ALA153 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 306 |
| Chain | Residue |
| A | MET107 |
| A | SER108 |
| A | HOH454 |
| A | HOH460 |
| B | SER217 |
| B | D45304 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | binding site for residue GLU A 307 |
| Chain | Residue |
| A | TYR61 |
| A | PRO89 |
| A | LEU90 |
| A | THR91 |
| A | ARG96 |
| A | GLY141 |
| A | SER142 |
| A | THR143 |
| A | GLU193 |
| A | TYR220 |
| A | HOH425 |
| A | HOH428 |
| A | HOH456 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 308 |
| Chain | Residue |
| A | SER194 |
| A | GLU198 |
| A | LYS210 |
| A | ASN214 |
| A | HOH401 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 309 |
| Chain | Residue |
| A | TYR199 |
| A | ARG203 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 310 |
| Chain | Residue |
| A | ASN22 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 311 |
| Chain | Residue |
| A | ASP58 |
| site_id | AD3 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 312 |
| Chain | Residue |
| A | THR5 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue PEG A 313 |
| Chain | Residue |
| A | LYS144 |
| A | ARG148 |
| A | ARG163 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 301 |
| Chain | Residue |
| A | LYS104 |
| A | HOH525 |
| B | GLU97 |
| B | ASP101 |
| B | PHE102 |
| B | HOH441 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 302 |
| Chain | Residue |
| B | SER140 |
| B | LYS144 |
| B | ARG148 |
| B | HOH408 |
| B | HOH449 |
| B | HOH492 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 303 |
| Chain | Residue |
| A | SER217 |
| B | MET107 |
| B | SER108 |
| B | D45304 |
| B | HOH414 |
| B | HOH453 |
| site_id | AD8 |
| Number of Residues | 16 |
| Details | binding site for residue D45 B 304 |
| Chain | Residue |
| A | LYS104 |
| A | PRO105 |
| A | SER108 |
| A | SER217 |
| A | LYS218 |
| A | GLY219 |
| A | SER242 |
| A | SO4306 |
| B | LYS104 |
| B | PRO105 |
| B | SER108 |
| B | SER217 |
| B | LYS218 |
| B | GLY219 |
| B | SER242 |
| B | SO4303 |
| site_id | AD9 |
| Number of Residues | 13 |
| Details | binding site for residue GLU B 305 |
| Chain | Residue |
| B | TYR220 |
| B | HOH425 |
| B | HOH437 |
| B | HOH461 |
| B | TYR61 |
| B | PRO89 |
| B | LEU90 |
| B | THR91 |
| B | ARG96 |
| B | GLY141 |
| B | SER142 |
| B | THR143 |
| B | GLU193 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue GOL B 306 |
| Chain | Residue |
| B | ASP58 |
| B | ASN72 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 307 |
| Chain | Residue |
| B | SER194 |
| B | GLU198 |
| B | LYS210 |
| B | ASN214 |
| site_id | AE3 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 308 |
| Chain | Residue |
| B | LYS4 |
| B | THR5 |
| site_id | AE4 |
| Number of Residues | 2 |
| Details | binding site for residue PEG B 309 |
| Chain | Residue |
| B | LYS144 |
| B | ARG148 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
