6HCA

STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S1J) IN COMPLEX WITH POSITIVE ALLOSTERIC MODULATOR TDPAM02 AT 1.8 A RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 A 301

Chain	Residue
A	ARG148
A	TRP159
A	ARG163
A	HOH501
B	LYS50

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 302

Chain	Residue
A	LYS251
A	HOH440
A	SER108
A	SER194
A	GLU198
A	ASN214

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 A 303

Chain	Residue
A	THR91
A	ARG96
A	HOH408
A	HOH425

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 304

Chain	Residue
A	LYS116
A	GOL310
A	HOH453
A	HOH508
B	LYS82

---

site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 A 305

Chain	Residue
A	LYS253
A	LYS258

---

site_id	AC6
Number of Residues	5
Details	binding site for residue SO4 A 306

Chain	Residue
A	HIS23
A	GLU24
A	ARG31
A	HOH433
A	HOH487

---

site_id	AC7
Number of Residues	2
Details	binding site for residue GOL A 307

Chain	Residue
A	ARG163
B	LYS50

---

site_id	AC8
Number of Residues	6
Details	binding site for residue GOL A 308

Chain	Residue
A	ARG163
A	GLU166
A	SER168
A	PHE170
A	HOH476
B	GLU176

---

site_id	AC9
Number of Residues	5
Details	binding site for residue GOL A 309

Chain	Residue
A	LYS117
A	GLU201
A	GLN202
A	CYS261
A	HOH434

---

site_id	AD1
Number of Residues	5
Details	binding site for residue GOL A 310

Chain	Residue
A	LYS116
A	LYS185
A	SO4304
A	HOH559
B	ILE70

---

site_id	AD2
Number of Residues	5
Details	binding site for residue GOL A 311

Chain	Residue
A	ALA124
A	ILE152
A	HOH403
A	HOH505
A	HOH579

---

site_id	AD3
Number of Residues	8
Details	binding site for residue GOL A 312

Chain	Residue
A	GLU176
A	HOH475
A	HOH585
B	ARG163
B	GLU166
B	SER168
B	PHE170
B	HOH445

---

site_id	AD4
Number of Residues	1
Details	binding site for residue CL A 313

Chain	Residue
A	ALA153

---

site_id	AD5
Number of Residues	2
Details	binding site for residue CL A 314

Chain	Residue
A	GLN130
A	THR131

---

site_id	AD6
Number of Residues	3
Details	binding site for residue CL A 315

Chain	Residue
A	LEU26
A	GLU27
A	GLU30

---

site_id	AD7
Number of Residues	2
Details	binding site for residue CL A 316

Chain	Residue
A	GLU13
A	SER14

---

site_id	AD8
Number of Residues	20
Details	binding site for residue FXW B 301

Chain	Residue
A	LYS104
A	PRO105
A	PHE106
A	MET107
A	SER108
A	LYS218
A	GLY219
A	LEU239
A	ASN242
A	HOH435
A	HOH532
B	LYS104
B	PRO105
B	PHE106
B	MET107
B	SER108
B	LYS218
B	GLY219
B	ASN242
B	HOH458

---

site_id	AD9
Number of Residues	5
Details	binding site for residue SO4 B 302

Chain	Residue
A	ARG172
B	ASP139
B	SER140
B	LYS144
B	ARG148

---

site_id	AE1
Number of Residues	9
Details	binding site for residue SO4 B 303

Chain	Residue
B	HOH462
B	SER108
B	SER194
B	GLU198
B	ASN214
B	LYS251
B	HOH404
B	HOH409
B	HOH410

---

site_id	AE2
Number of Residues	4
Details	binding site for residue SO4 B 304

Chain	Residue
B	ARG148
B	TRP159
B	ARG163
B	HOH557

---

site_id	AE3
Number of Residues	5
Details	binding site for residue SO4 B 305

Chain	Residue
B	HIS23
B	GLU24
B	ARG31
B	HIS46
B	LYS240

---

site_id	AE4
Number of Residues	3
Details	binding site for residue GOL B 306

Chain	Residue
B	LYS117
B	GLN202
B	HOH439

---

site_id	AE5
Number of Residues	1
Details	binding site for residue CL B 307

Chain	Residue
B	GLU27

---

site_id	AE6
Number of Residues	1
Details	binding site for residue CL B 308

Chain	Residue
B	ALA153

---

site_id	AE7
Number of Residues	5
Details	binding site for residue PEG B 309

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	THR91
B	ARG96

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---