6HAV

Crystal structure of [Fe]-hydrogenase (Hmd) from Methanococcus aeolicus in complex with FeGP and methenyl-tetrahydromethanopterin (close form A) at 1.06 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004735	molecular_function	pyrroline-5-carboxylate reductase activity
A	0006730	biological_process	one-carbon metabolic process
A	0015948	biological_process	methanogenesis
A	0016491	molecular_function	oxidoreductase activity
A	0019386	biological_process	methanogenesis, from carbon dioxide
A	0047068	molecular_function	N5,N10-methenyltetrahydromethanopterin hydrogenase activity
A	0055129	biological_process	L-proline biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	32
Details	binding site for residue FE9 A 401

Chain	Residue
A	LEU6
A	CYS66
A	PRO114
A	PRO115
A	CYS118
A	ASP135
A	TRP148
A	LEU149
A	PRO150
A	ILE158
A	ALA175
A	GLY7
A	CYS176
A	THR177
A	HIS201
A	PRO202
A	GLY203
A	CYS204
A	VAL205
A	PRO206
A	E4M412
A	HOH545
A	GLY9
A	HOH579
A	HOH598
A	HOH632
A	CYS10
A	SER13
A	HIS14
A	SER63
A	ASP64
A	PRO65

---

site_id	AC2
Number of Residues	11
Details	binding site for residue GOL A 402

Chain	Residue
A	ILE76
A	ASP77
A	GLU78
A	GLY217
A	TYR218
A	ALA219
A	SER220
A	HOH512
A	HOH553
A	HOH619
A	HOH620

---

site_id	AC3
Number of Residues	6
Details	binding site for residue GOL A 403

Chain	Residue
A	PHE239
A	HOH533
A	HOH574
A	HOH657
A	HOH804
A	HOH846

---

site_id	AC4
Number of Residues	11
Details	binding site for residue GOL A 404

Chain	Residue
A	GLU78
A	ASP102
A	ALA103
A	GLY217
A	TYR218
A	ASN244
A	HOH513
A	HOH529
A	HOH605
A	HOH693
A	HOH749

---

site_id	AC5
Number of Residues	11
Details	binding site for residue GOL A 405

Chain	Residue
A	ALA29
A	ASN30
A	GLY33
A	ILE34
A	PRO35
A	ASP58
A	LYS82
A	MET85
A	HOH519
A	HOH559
A	HOH648

---

site_id	AC6
Number of Residues	6
Details	binding site for residue GOL A 406

Chain	Residue
A	LEU294
A	GLU295
A	ARG298
A	ARG298
A	HOH785
A	HOH785

---

site_id	AC7
Number of Residues	5
Details	binding site for residue NA A 407

Chain	Residue
A	LEU51
A	VAL54
A	ILE57
A	HOH648
A	HOH807

---

site_id	AC8
Number of Residues	6
Details	binding site for residue NA A 408

Chain	Residue
A	HIS52
A	VAL127
A	GLY128
A	HOH842
A	HOH989
A	HOH989

---

site_id	AC9
Number of Residues	3
Details	binding site for residue SCN A 409

Chain	Residue
A	GLY152
A	HOH651
A	HOH825

---

site_id	AD1
Number of Residues	3
Details	binding site for residue SCN A 410

Chain	Residue
A	GLY153
A	PHE281
A	HOH948

---

site_id	AD2
Number of Residues	3
Details	binding site for residue SCN A 411

Chain	Residue
A	GLY324
A	PRO325
A	HOH531

---

site_id	AD3
Number of Residues	30
Details	binding site for residue E4M A 412

Chain	Residue
A	LYS113
A	PRO114
A	PRO150
A	LYS151
A	CYS176
A	GLY203
A	CYS250
A	ASP251
A	MET252
A	SER254
A	PRO278
A	PHE281
A	THR317
A	SER320
A	MET321
A	FE9401
A	HOH505
A	HOH508
A	HOH539
A	HOH545
A	HOH547
A	HOH593
A	HOH629
A	HOH632
A	HOH667
A	HOH731
A	HOH796
A	HOH806
A	SER13
A	CYS17

---