6H9S
Crystal dimeric structure of Petrotoga mobilis lactate dehydrogenase with NADH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0006090 | biological_process | pyruvate metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0006090 | biological_process | pyruvate metabolic process |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue NAD A 401 |
| Chain | Residue |
| A | GLY9 |
| A | ILE115 |
| A | ASN117 |
| A | THR140 |
| A | HIS172 |
| A | THR228 |
| A | HOH507 |
| A | HOH513 |
| A | HOH521 |
| A | HOH523 |
| A | HOH533 |
| A | ARG10 |
| A | HOH550 |
| A | HOH551 |
| A | HOH563 |
| A | HOH575 |
| A | VAL11 |
| A | ASP32 |
| A | LEU33 |
| A | THR74 |
| A | ALA75 |
| A | GLY76 |
| A | ILE95 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | binding site for residue NAD B 401 |
| Chain | Residue |
| B | GLY9 |
| B | ARG10 |
| B | VAL11 |
| B | ASP32 |
| B | LEU33 |
| B | THR74 |
| B | ALA75 |
| B | GLY76 |
| B | ALA77 |
| B | ALA78 |
| B | ILE95 |
| B | ILE115 |
| B | ASN117 |
| B | THR140 |
| B | HIS172 |
| B | THR228 |
| B | HOH512 |
| B | HOH515 |
| B | HOH528 |
| B | HOH532 |
| B | HOH533 |
| B | HOH545 |
| B | HOH555 |
| B | HOH580 |
Functional Information from PROSITE/UniProt
| site_id | PS00064 |
| Number of Residues | 7 |
| Details | L_LDH L-lactate dehydrogenase active site. IGEHGDS |
| Chain | Residue | Details |
| A | ILE169-SER175 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00488 |
| Chain | Residue | Details |
| A | HIS172 | |
| B | HIS172 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 26 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00488 |
| Chain | Residue | Details |
| A | TYR62 | |
| A | GLY76 | |
| A | GLN79 | |
| A | ARG85 | |
| A | ILE115 | |
| A | ASN117 | |
| A | THR140 | |
| A | ASP145 | |
| A | ARG150 | |
| A | HIS165 | |
| A | THR228 | |
| B | VAL11 | |
| B | ASP32 | |
| B | TYR62 | |
| B | GLY76 | |
| B | GLN79 | |
| B | ARG85 | |
| B | ILE115 | |
| B | ASN117 | |
| B | THR140 | |
| B | ASP145 | |
| B | ARG150 | |
| B | HIS165 | |
| B | THR228 | |
| A | VAL11 | |
| A | ASP32 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000255|HAMAP-Rule:MF_00488 |
| Chain | Residue | Details |
| A | TYR219 | |
| B | TYR219 |
