6H7S
Sulfolobus solfataricus 2-keto-3-deoxygluconate aldolase T157V/A198L variant in complex with L-2-keto-3deoxy-gluconate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0008674 | molecular_function | 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity |
| A | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| A | 0008700 | molecular_function | 4-hydroxy-2-oxoglutarate aldolase activity |
| A | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| A | 0009436 | biological_process | glyoxylate catabolic process |
| A | 0016829 | molecular_function | lyase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008674 | molecular_function | 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity |
| B | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| B | 0008700 | molecular_function | 4-hydroxy-2-oxoglutarate aldolase activity |
| B | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| B | 0009436 | biological_process | glyoxylate catabolic process |
| B | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue FW2 A 301 |
| Chain | Residue |
| A | PRO7 |
| A | VAL196 |
| A | PHE39 |
| A | GLY42 |
| A | THR43 |
| A | THR44 |
| A | TYR130 |
| A | TYR132 |
| A | LYS155 |
| A | GLY179 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue FW2 B 301 |
| Chain | Residue |
| B | PRO7 |
| B | THR43 |
| B | THR44 |
| B | TYR130 |
| B | TYR132 |
| B | LYS155 |
| B | GLY179 |
| B | LEU198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Schiff-base intermediate with substrate => ECO:0000269|PubMed:15265860 |
| Chain | Residue | Details |
| A | LYS155 | |
| B | LYS155 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | THR43 | |
| A | TYR130 | |
| A | LYS155 | |
| B | THR43 | |
| B | TYR130 | |
| B | LYS155 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Proton shuttle => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR130 | |
| B | TYR130 |
