Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6H6H

Crystal structures of the murine class I major histocompatibility complex H-2Dbm13 in complex with adenovirus-derived peptide Ad10

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
A	0006955	biological_process	immune response
A	0016020	cellular_component	membrane
A	0019882	biological_process	antigen processing and presentation
A	0030670	cellular_component	phagocytic vesicle membrane
A	0042612	cellular_component	MHC class I protein complex
A	0098553	cellular_component	lumenal side of endoplasmic reticulum membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002376	biological_process	immune system process
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0006968	biological_process	cellular defense response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0010038	biological_process	response to metal ion
B	0010977	biological_process	negative regulation of neuron projection development
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031902	cellular_component	late endosome membrane
B	0033077	biological_process	T cell differentiation in thymus
B	0033572	biological_process	transferrin transport
B	0034756	biological_process	regulation of iron ion transport
B	0034757	biological_process	negative regulation of iron ion transport
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0048261	biological_process	negative regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
D	0002376	biological_process	immune system process
D	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
D	0006955	biological_process	immune response
D	0016020	cellular_component	membrane
D	0019882	biological_process	antigen processing and presentation
D	0030670	cellular_component	phagocytic vesicle membrane
D	0042612	cellular_component	MHC class I protein complex
D	0098553	cellular_component	lumenal side of endoplasmic reticulum membrane
E	0001913	biological_process	T cell mediated cytotoxicity
E	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
E	0002237	biological_process	response to molecule of bacterial origin
E	0002376	biological_process	immune system process
E	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
E	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
E	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
E	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
E	0002726	biological_process	positive regulation of T cell cytokine production
E	0005198	molecular_function	structural molecule activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005765	cellular_component	lysosomal membrane
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006955	biological_process	immune response
E	0006968	biological_process	cellular defense response
E	0007608	biological_process	sensory perception of smell
E	0007611	biological_process	learning or memory
E	0009897	cellular_component	external side of plasma membrane
E	0010038	biological_process	response to metal ion
E	0010977	biological_process	negative regulation of neuron projection development
E	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
E	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
E	0023026	molecular_function	MHC class II protein complex binding
E	0030670	cellular_component	phagocytic vesicle membrane
E	0031902	cellular_component	late endosome membrane
E	0033077	biological_process	T cell differentiation in thymus
E	0033572	biological_process	transferrin transport
E	0034756	biological_process	regulation of iron ion transport
E	0034757	biological_process	negative regulation of iron ion transport
E	0042026	biological_process	protein refolding
E	0042605	molecular_function	peptide antigen binding
E	0042612	cellular_component	MHC class I protein complex
E	0042613	cellular_component	MHC class II protein complex
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0042824	cellular_component	MHC class I peptide loading complex
E	0045646	biological_process	regulation of erythrocyte differentiation
E	0048260	biological_process	positive regulation of receptor-mediated endocytosis
E	0048261	biological_process	negative regulation of receptor-mediated endocytosis
E	0050680	biological_process	negative regulation of epithelial cell proliferation
E	0050768	biological_process	negative regulation of neurogenesis
E	0050778	biological_process	positive regulation of immune response
E	0050870	biological_process	positive regulation of T cell activation
E	0051289	biological_process	protein homotetramerization
E	0060586	biological_process	multicellular organismal-level iron ion homeostasis
E	0071281	biological_process	cellular response to iron ion
E	0071283	biological_process	cellular response to iron(III) ion
E	0071316	biological_process	cellular response to nicotine
E	1990000	biological_process	amyloid fibril formation
E	1990712	cellular_component	HFE-transferrin receptor complex
E	2000774	biological_process	positive regulation of cellular senescence
E	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue SO4 A 401

Chain	Residue
A	TRP167

site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 402

Chain	Residue
A	PRO20
A	ARG75
A	ARG79

site_id	AC3
Number of Residues	9
Details	binding site for residue SO4 A 403

Chain	Residue
D	GLN65
D	LYS66
D	GLY69
F	SER4
A	GLN65
A	LYS66
A	GLY69
C	SER4
C	HOH101

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 404

Chain	Residue
A	GLU58
A	TYR59
A	ARG62
A	TRP167

site_id	AC5
Number of Residues	1
Details	binding site for residue SO4 A 405

Chain	Residue
A	ARG144

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL A 406

Chain	Residue
A	PHE8
A	TYR27
A	ASN30
B	PHE56
B	TYR63

site_id	AC7
Number of Residues	6
Details	binding site for residue GOL A 407

Chain	Residue
A	THR10
A	VAL12
A	ILE23
B	PRO33
B	MET54
B	PHE62

site_id	AC8
Number of Residues	4
Details	binding site for residue SO4 D 401

Chain	Residue
D	PHE8
D	TYR27
D	ASN30
E	LYS58

site_id	AC9
Number of Residues	3
Details	binding site for residue SO4 D 402

Chain	Residue
D	PRO20
D	ARG75
D	ARG79

site_id	AD1
Number of Residues	7
Details	binding site for residue SO4 D 403

Chain	Residue
D	TRP204
D	ARG234
D	GLN242
E	SER11
E	HIS13
E	ARG97
E	MET99

site_id	AD2
Number of Residues	3
Details	binding site for residue SO4 B 101

Chain	Residue
B	ARG12
B	HIS13
B	SO4102

site_id	AD3
Number of Residues	4
Details	binding site for residue SO4 B 102

Chain	Residue
B	PRO20
B	ASN21
B	ILE22
B	SO4101

site_id	AD4
Number of Residues	4
Details	binding site for residue SO4 B 103

Chain	Residue
B	LYS41
B	PHE70
B	THR71
B	TYR78

site_id	AD5
Number of Residues	2
Details	binding site for residue SO4 B 104

Chain	Residue
B	PRO47
B	LYS48

site_id	AD6
Number of Residues	2
Details	binding site for residue SO4 B 105

Chain	Residue
B	ARG12
B	HIS67

site_id	AD7
Number of Residues	1
Details	binding site for residue SO4 E 101

Chain	Residue
E	ARG81

site_id	AD8
Number of Residues	3
Details	binding site for residue SO4 E 102

Chain	Residue
E	ARG12
E	ILE22
E	HIS67

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVKH

Chain	Residue	Details
B	TYR78-HIS84
A	TYR257-HIS263

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)