6H57

Crystal structure of S. cerevisiae DEAH-box RNA helicase Dhr1, essential for small ribosomal subunit biogenesis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000462	biological_process	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0003724	molecular_function	RNA helicase activity
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005739	cellular_component	mitochondrion
A	0006364	biological_process	rRNA processing
A	0006396	biological_process	RNA processing
A	0008186	molecular_function	ATP-dependent activity, acting on RNA
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0022613	biological_process	ribonucleoprotein complex biogenesis
A	0030490	biological_process	maturation of SSU-rRNA
A	0030686	cellular_component	90S preribosome
A	0032040	cellular_component	small-subunit processome
A	0042254	biological_process	ribosome biogenesis
A	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue EDO A 1301

Chain	Residue
A	PRO589
A	PHE1000
A	GLU1146
A	MET1147
A	PRO1148
A	PRO1149
A	EDO1302
A	HOH1409
A	HOH1572

---

site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 1302

Chain	Residue
A	PRO1149
A	LYS1150
A	TYR1151
A	ASP1172
A	ILE1173
A	EDO1301

---

site_id	AC3
Number of Residues	6
Details	binding site for residue EDO A 1303

Chain	Residue
A	HIS405
A	HIS406
A	ASP408
A	LYS552
A	LYS554
A	HOH1436

---

site_id	AC4
Number of Residues	7
Details	binding site for residue EDO A 1304

Chain	Residue
A	LEU1099
A	ARG1216
A	THR1220
A	ASN1223
A	ASP1224
A	LYS1226
A	GLY1228

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 1305

Chain	Residue
A	MET401
A	HIS405
A	TYR441

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 1306

Chain	Residue
A	GLN884
A	LEU889
A	ASP890
A	LEU1186
A	HOH1471

---

site_id	AC7
Number of Residues	3
Details	binding site for residue EDO A 1307

Chain	Residue
A	ARG640
A	TYR730
A	VAL731

---

site_id	AC8
Number of Residues	4
Details	binding site for residue EDO A 1308

Chain	Residue
A	LYS878
A	GLN881
A	TYR885
A	EDO1309

---

site_id	AC9
Number of Residues	8
Details	binding site for residue EDO A 1309

Chain	Residue
A	LYS878
A	GLN881
A	LEU882
A	TYR885
A	ARG910
A	ASP1090
A	EDO1308
A	HOH1405

---

site_id	AD1
Number of Residues	7
Details	binding site for residue EDO A 1310

Chain	Residue
A	GLU415
A	THR416
A	GLY417
A	SER418
A	GLY419
A	THR421
A	THR422

---

site_id	AD2
Number of Residues	3
Details	binding site for residue EDO A 1311

Chain	Residue
A	THR896
A	GLU897
A	ASP898

---

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO A 1312

Chain	Residue
A	GLU545
A	ASN546
A	ILE548
A	HOH1507

---

site_id	AD4
Number of Residues	3
Details	binding site for residue EDO A 1313

Chain	Residue
A	THR1123
A	ASP1130
A	CYS1131

---

site_id	AD5
Number of Residues	4
Details	binding site for residue EDO A 1314

Chain	Residue
A	GLU500
A	HIS503
A	LYS509
A	HOH1480

---

site_id	AD6
Number of Residues	6
Details	binding site for residue MG A 1315

Chain	Residue
A	GLN881
A	GLN884
A	HOH1439
A	HOH1520
A	HOH1628
A	HOH1634

---

site_id	AD7
Number of Residues	2
Details	binding site for residue CL A 1317

Chain	Residue
A	GLY474
A	TYR475

---

site_id	AD8
Number of Residues	2
Details	binding site for residue CL A 1318

Chain	Residue
A	PRO871
A	ASP872

---

site_id	AD9
Number of Residues	2
Details	binding site for residue CL A 1319

Chain	Residue
A	ASN1168
A	THR1169

---

Functional Information from PROSITE/UniProt

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. SsIIIDEAHE

Chain	Residue	Details
A	SER511-GLU520

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	179
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Motif: {"description":"DEAH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---