6H53
Crystal structure of Mycobacterium tuberculosis phosphatidylinositol phosphate synthase (PgsA1) in apo form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003881 | molecular_function | CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008654 | biological_process | phospholipid biosynthetic process |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0016020 | cellular_component | membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016780 | molecular_function | phosphotransferase activity, for other substituted phosphate groups |
| A | 0046474 | biological_process | glycerophospholipid biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003881 | molecular_function | CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0008654 | biological_process | phospholipid biosynthetic process |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0016020 | cellular_component | membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016780 | molecular_function | phosphotransferase activity, for other substituted phosphate groups |
| B | 0046474 | biological_process | glycerophospholipid biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 301 |
| Chain | Residue |
| A | ILE131 |
| A | SER132 |
| A | ARG152 |
| A | ARG155 |
| A | ARG195 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue UPL A 302 |
| Chain | Residue |
| A | TRP62 |
| A | VAL165 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue UPL A 304 |
| Chain | Residue |
| A | TRP106 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue UPL A 305 |
| Chain | Residue |
| A | ASP167 |
| A | PRO169 |
| A | CYS59 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 306 |
| Chain | Residue |
| A | TRP106 |
| A | HIS111 |
| B | ARG115 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 301 |
| Chain | Residue |
| B | ARG94 |
| B | SER132 |
| B | ARG152 |
| B | ARG195 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue UPL B 302 |
| Chain | Residue |
| B | CYS102 |
| B | TRP106 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue UPL B 303 |
| Chain | Residue |
| B | THR39 |
| B | THR47 |
Functional Information from PROSITE/UniProt
| site_id | PS00379 |
| Number of Residues | 23 |
| Details | CDP_ALCOHOL_P_TRANSF CDP-alcohol phosphatidyltransferases signature. DGamARergggtrfGavlDatcD |
| Chain | Residue | Details |
| A | ASP71-ASP93 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 262 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"31098408","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"31098408","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31098408","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
