6H4Z
Crystal structure of human KDM5B in complex with compound 16a
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 801 |
| Chain | Residue |
| A | CYS692 |
| A | CYS695 |
| A | CYS715 |
| A | HIS718 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 802 |
| Chain | Residue |
| A | CYS706 |
| A | CYS708 |
| A | CYS723 |
| A | CYS725 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 803 |
| Chain | Residue |
| A | GLU501 |
| A | HIS587 |
| A | FQ5805 |
| A | HOH920 |
| A | HIS499 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MN A 804 |
| Chain | Residue |
| A | LEU90 |
| A | ASN91 |
| A | LEU413 |
| A | THR416 |
| A | GLU419 |
| A | HOH936 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residue FQ5 A 805 |
| Chain | Residue |
| A | TYR425 |
| A | ASP428 |
| A | CYS480 |
| A | TYR488 |
| A | PHE496 |
| A | HIS499 |
| A | GLU501 |
| A | LYS517 |
| A | TRP519 |
| A | HIS587 |
| A | MN803 |
| A | DMS807 |
| A | DMS811 |
| A | HOH920 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue FQ5 A 806 |
| Chain | Residue |
| A | GLU31 |
| A | GLN58 |
| A | TYR525 |
| A | TYR569 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue DMS A 807 |
| Chain | Residue |
| A | TRP486 |
| A | TYR488 |
| A | GLU501 |
| A | ASN601 |
| A | FQ5805 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 808 |
| Chain | Residue |
| A | TRP504 |
| A | HIS617 |
| A | TYR618 |
| A | EDO821 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 809 |
| Chain | Residue |
| A | GLU631 |
| A | GLU683 |
| A | PHE700 |
| A | TYR736 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 811 |
| Chain | Residue |
| A | ARG98 |
| A | PHE496 |
| A | CYS497 |
| A | HIS499 |
| A | FQ5805 |
| A | DMS812 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue DMS A 812 |
| Chain | Residue |
| A | GLN88 |
| A | GLN96 |
| A | THR97 |
| A | SER495 |
| A | PHE496 |
| A | CYS497 |
| A | DMS811 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue DMS A 813 |
| Chain | Residue |
| A | ARG666 |
| A | SER677 |
| site_id | AD4 |
| Number of Residues | 1 |
| Details | binding site for residue DMS A 814 |
| Chain | Residue |
| A | CYS723 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 815 |
| Chain | Residue |
| A | HIS399 |
| A | HIS399 |
| A | HOH903 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 816 |
| Chain | Residue |
| A | ASP630 |
| A | CYS699 |
| A | PHE700 |
| A | MET701 |
| A | SER702 |
| A | HOH902 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 817 |
| Chain | Residue |
| A | GLY524 |
| A | ARG584 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 818 |
| Chain | Residue |
| A | HIS622 |
| A | HIS718 |
| A | HOH941 |
| A | HOH984 |
| A | HOH1003 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 819 |
| Chain | Residue |
| A | ASP688 |
| A | GLU689 |
| A | ARG690 |
| A | GLN691 |
| A | GLY711 |
| A | LEU713 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 820 |
| Chain | Residue |
| A | MET25 |
| A | LEU27 |
| A | ASN559 |
| A | PRO743 |
| A | ASN746 |
| A | HOH938 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 821 |
| Chain | Residue |
| A | DMS808 |
| A | ASP502 |
| A | GLN551 |
| A | TYR618 |
| A | ARG623 |
| A | TYR624 |
| site_id | AE3 |
| Number of Residues | 1 |
| Details | binding site for residue MN A 822 |
| Chain | Residue |
| A | ASP630 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 41 |
| Details | Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 166 |
| Details | Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 52 |
| Details | Zinc finger: {"description":"C5HC2","evidences":[{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27214403","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28262558","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P29375","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27214403","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28262558","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
