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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6H4O

Crystal structure of human KDM4A in complex with compound 18a

Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 401
ChainResidue
AHIS188
AGLU190
AHIS276
AFQH403
site_idAC2
Number of Residues4
Detailsbinding site for residue ZN A 402
ChainResidue
ACYS234
AHIS240
ACYS306
ACYS308
site_idAC3
Number of Residues11
Detailsbinding site for residue FQH A 403
ChainResidue
ATYR177
APHE185
AHIS188
AGLU190
AASP191
ALYS206
ATRP208
AHIS276
AZN401
AHOH576
ATYR132
site_idAC4
Number of Residues11
Detailsbinding site for residue GOL A 404
ChainResidue
AVAL75
ATHR76
AGLY77
ATHR126
APHE127
AHOH550
CVAL75
CTHR76
CGLY77
CTHR126
CPHE127
site_idAC5
Number of Residues1
Detailsbinding site for residue CL A 405
ChainResidue
ATYR59
site_idAC6
Number of Residues4
Detailsbinding site for residue ZN B 401
ChainResidue
BHIS188
BGLU190
BHIS276
BFQH403
site_idAC7
Number of Residues4
Detailsbinding site for residue ZN B 402
ChainResidue
BCYS234
BHIS240
BCYS306
BCYS308
site_idAC8
Number of Residues10
Detailsbinding site for residue FQH B 403
ChainResidue
BTYR132
BTYR175
BTYR177
BPHE185
BHIS188
BGLU190
BLYS206
BTRP208
BHIS276
BZN401
site_idAC9
Number of Residues10
Detailsbinding site for residue GOL B 404
ChainResidue
BVAL75
BTHR76
BGLY77
BTHR126
BPHE127
DVAL75
DTHR76
DGLY77
DTHR126
DPHE127
site_idAD1
Number of Residues5
Detailsbinding site for residue ZN C 401
ChainResidue
CHIS188
CGLU190
CHIS276
CFQH403
CHOH501
site_idAD2
Number of Residues4
Detailsbinding site for residue ZN C 402
ChainResidue
CCYS234
CHIS240
CCYS306
CCYS308
site_idAD3
Number of Residues14
Detailsbinding site for residue FQH C 403
ChainResidue
CTYR132
CASP135
CGLU169
CTYR175
CTYR177
CPHE185
CHIS188
CGLU190
CASP191
CLYS206
CTRP208
CHIS276
CZN401
CHOH501
site_idAD4
Number of Residues4
Detailsbinding site for residue DMS C 404
ChainResidue
CALA12
CARG13
CPHE257
CHOH543
site_idAD5
Number of Residues2
Detailsbinding site for residue DMS C 405
ChainResidue
CARG294
CPHE324
site_idAD6
Number of Residues1
Detailsbinding site for residue CL C 406
ChainResidue
CHOH592
site_idAD7
Number of Residues5
Detailsbinding site for residue ZN D 401
ChainResidue
DHIS188
DGLU190
DHIS276
DFQH403
DHOH506
site_idAD8
Number of Residues4
Detailsbinding site for residue ZN D 402
ChainResidue
DCYS234
DHIS240
DCYS306
DCYS308
site_idAD9
Number of Residues11
Detailsbinding site for residue FQH D 403
ChainResidue
DASP135
DTYR177
DPHE185
DHIS188
DGLU190
DLYS206
DTRP208
DHIS276
DZN401
DHOH506
DTYR132
site_idAE1
Number of Residues6
Detailsbinding site for residue DMS D 404
ChainResidue
DASP193
DLYS217
DTYR273
DTYR299
DGLN302
DHIS343
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues168
DetailsDomain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16677698","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16677698","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"16677698","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PDB","id":"5F2W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F32","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F39","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5I","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"B2RXH2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues166
DetailsDomain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 370
ChainResidueDetails
AGLY170hydrogen bond acceptor, steric role
ATYR177hydrogen bond donor, steric role
AHIS188metal ligand
AGLU190attractive charge-charge interaction, hydrogen bond acceptor, metal ligand, steric role
AHIS276metal ligand
ASER288hydrogen bond donor, steric role
site_idMCSA2
Number of Residues6
DetailsM-CSA 370
ChainResidueDetails
BGLY170hydrogen bond acceptor, steric role
BTYR177hydrogen bond donor, steric role
BHIS188metal ligand
BGLU190attractive charge-charge interaction, hydrogen bond acceptor, metal ligand, steric role
BHIS276metal ligand
BSER288hydrogen bond donor, steric role
site_idMCSA3
Number of Residues6
DetailsM-CSA 370
ChainResidueDetails
CGLY170hydrogen bond acceptor, steric role
CTYR177hydrogen bond donor, steric role
CHIS188metal ligand
CGLU190attractive charge-charge interaction, hydrogen bond acceptor, metal ligand, steric role
CHIS276metal ligand
CSER288hydrogen bond donor, steric role
site_idMCSA4
Number of Residues6
DetailsM-CSA 370
ChainResidueDetails
DGLY170hydrogen bond acceptor, steric role
DTYR177hydrogen bond donor, steric role
DHIS188metal ligand
DGLU190attractive charge-charge interaction, hydrogen bond acceptor, metal ligand, steric role
DHIS276metal ligand
DSER288hydrogen bond donor, steric role

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PDB entries from 2025-10-22

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