6H43

Flavin-dependent Tryptophan 6-halogenase Thal

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004497	molecular_function	monooxygenase activity
A	0016491	molecular_function	oxidoreductase activity
B	0000166	molecular_function	nucleotide binding
B	0004497	molecular_function	monooxygenase activity
B	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue PO4 A 601

Chain	Residue
A	ARG158
A	ARG164
A	HOH795

---

site_id	AC2
Number of Residues	4
Details	binding site for residue PO4 A 602

Chain	Residue
A	ARG439
A	HOH707
A	HOH768
B	GOL606

---

site_id	AC3
Number of Residues	4
Details	binding site for residue GOL A 603

Chain	Residue
A	ILE219
A	GLN221
A	GLU192
A	ARG218

---

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 604

Chain	Residue
A	PRO53
A	ARG164
A	ASN167
A	TYR168
A	TYR455
A	HOH724

---

site_id	AC5
Number of Residues	3
Details	binding site for residue GOL A 605

Chain	Residue
A	GLY12
A	ALA39
A	MET198

---

site_id	AC6
Number of Residues	4
Details	binding site for residue GOL A 606

Chain	Residue
A	THR15
A	GLU49
A	GLY361
A	ILE362

---

site_id	AC7
Number of Residues	5
Details	binding site for residue GOL A 607

Chain	Residue
A	GLY25
A	LYS26
A	GLN29
A	ASN30
A	HOH771

---

site_id	AC8
Number of Residues	9
Details	binding site for residue GOL A 608

Chain	Residue
A	ARG88
A	TRP127
A	ASN139
A	PHE140
A	ALA476
A	GLY477
A	GLY479
A	HOH738
A	HOH844

---

site_id	AC9
Number of Residues	6
Details	binding site for residue GOL A 609

Chain	Residue
A	TYR23
A	TYR62
A	HIS370
A	ALA373
B	ASP119
B	LYS492

---

site_id	AD1
Number of Residues	4
Details	binding site for residue GOL A 610

Chain	Residue
A	ARG88
A	LEU100
A	ASP101
A	PRO412

---

site_id	AD2
Number of Residues	6
Details	binding site for residue GOL A 611

Chain	Residue
A	ASP399
A	PHE462
A	ARG463
A	ASN464
A	PHE465
A	HOH735

---

site_id	AD3
Number of Residues	4
Details	binding site for residue K A 612

Chain	Residue
A	GLY222
A	ASP223
A	HOH769
A	HOH803

---

site_id	AD4
Number of Residues	2
Details	binding site for residue PO4 B 601

Chain	Residue
B	ARG439
B	ARG483

---

site_id	AD5
Number of Residues	2
Details	binding site for residue PO4 B 602

Chain	Residue
B	THR136
B	ASP137

---

site_id	AD6
Number of Residues	2
Details	binding site for residue PO4 B 603

Chain	Residue
B	ARG337
B	PO4604

---

site_id	AD7
Number of Residues	3
Details	binding site for residue PO4 B 604

Chain	Residue
B	ARG338
B	ARG342
B	PO4603

---

site_id	AD8
Number of Residues	8
Details	binding site for residue GOL B 605

Chain	Residue
A	ASP119
A	GLN120
A	ILE121
A	LYS492
B	TYR23
B	ALA27
B	TYR62
B	ALA373

---

site_id	AD9
Number of Residues	7
Details	binding site for residue GOL B 606

Chain	Residue
A	PO4602
B	ILE209
B	THR210
B	GLN221
B	GLY222
B	ASP223
B	HOH813

---

site_id	AE1
Number of Residues	5
Details	binding site for residue GOL B 607

Chain	Residue
B	THR15
B	GLU49
B	LEU349
B	GLY361
B	HOH778

---

site_id	AE2
Number of Residues	8
Details	binding site for residue GOL B 608

Chain	Residue
A	ARG206
B	ASN30
B	VAL32
B	LYS33
B	ILE34
B	GLN189
B	ALA190
B	HOH711

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"30559288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33465708","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31589794","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33465708","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SLS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CU1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33465708","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CU1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31589794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SLS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31589794","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SLS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SLT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30559288","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31589794","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33465708","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6H44","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7CU0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"E9P162","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Site: {"description":"Important for activity","evidences":[{"source":"UniProtKB","id":"P95480","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---