6H38
The crystal structure of human carbonic anhydrase VII in complex with 4-[(4-fluorophenyl)methyl]-1-piperazinyl]benzenesulfonamide.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004089 | molecular_function | carbonate dehydratase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016829 | molecular_function | lyase activity |
| A | 0032230 | biological_process | positive regulation of synaptic transmission, GABAergic |
| A | 0032849 | biological_process | positive regulation of cellular pH reduction |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051453 | biological_process | regulation of intracellular pH |
| A | 0070050 | biological_process | neuron cellular homeostasis |
| A | 2001225 | biological_process | regulation of chloride transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 301 |
| Chain | Residue |
| A | HIS94 |
| A | HIS96 |
| A | HIS119 |
| A | FKK302 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | binding site for residue FKK A 302 |
| Chain | Residue |
| A | VAL121 |
| A | PHE131 |
| A | ARG159 |
| A | LEU198 |
| A | THR199 |
| A | THR200 |
| A | PRO201 |
| A | PRO202 |
| A | ZN301 |
| A | GOL303 |
| A | HOH423 |
| A | HOH522 |
| A | TYR20 |
| A | GLN92 |
| A | HIS94 |
| A | HIS96 |
| A | HIS119 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | ASN62 |
| A | HIS64 |
| A | SER65 |
| A | GLN67 |
| A | GLN92 |
| A | HIS94 |
| A | THR200 |
| A | FKK302 |
| A | HOH432 |
| A | HOH479 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 304 |
| Chain | Residue |
| A | LYS18 |
| A | LEU19 |
| A | CYS54 |
| A | MET55 |
| A | HOH426 |
| A | HOH460 |
Functional Information from PROSITE/UniProt
| site_id | PS00162 |
| Number of Residues | 17 |
| Details | ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVdgksFpsELHLV |
| Chain | Residue | Details |
| A | SER105-VAL121 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2010","submissionDatabase":"PDB data bank","title":"Crystal structure of human carbonic anhydrase VII [isoform 1], CA7.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
