6H2R
Sulfolobus solfataricus 2-keto-3-deoxygluconate aldolase T157V/D181Q/A198L variant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008674 | molecular_function | 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity |
| A | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| A | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| A | 0016829 | molecular_function | lyase activity |
| B | 0008674 | molecular_function | 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity |
| B | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| B | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| B | 0016829 | molecular_function | lyase activity |
| C | 0008674 | molecular_function | 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity |
| C | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| C | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| C | 0016829 | molecular_function | lyase activity |
| D | 0008674 | molecular_function | 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity |
| D | 0008675 | molecular_function | 2-dehydro-3-deoxy-phosphogluconate aldolase activity |
| D | 0008840 | molecular_function | 4-hydroxy-tetrahydrodipicolinate synthase activity |
| D | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue IPA A 301 |
| Chain | Residue |
| A | HIS125 |
| A | HOH436 |
| A | HOH503 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue IPA A 302 |
| Chain | Residue |
| A | LEU198 |
| A | PRO7 |
| A | THR43 |
| A | THR44 |
| A | TYR130 |
| A | TYR132 |
| A | VAL157 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | GLY240 |
| A | SER241 |
| A | LEU242 |
| A | SER243 |
| A | PRO263 |
| A | ILE264 |
| B | ARG106 |
| B | MET107 |
| B | SER108 |
| B | HIS111 |
| B | HOH414 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | ILE93 |
| A | PRO124 |
| A | HIS125 |
| A | PRO126 |
| A | HOH409 |
| A | HOH439 |
| A | HOH440 |
| A | HOH600 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue IPA B 301 |
| Chain | Residue |
| B | PRO7 |
| B | THR43 |
| B | THR44 |
| B | TYR130 |
| B | VAL157 |
| B | LEU198 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 302 |
| Chain | Residue |
| A | ARG106 |
| A | MET107 |
| A | SER108 |
| A | HIS111 |
| B | GLY240 |
| B | SER241 |
| B | LEU242 |
| B | SER243 |
| B | PRO263 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | binding site for residue PGE B 303 |
| Chain | Residue |
| A | TYR103 |
| A | TYR104 |
| A | THR134 |
| A | ALA135 |
| A | THR136 |
| A | GLY137 |
| A | LYS138 |
| A | HOH499 |
| B | TYR103 |
| B | TYR104 |
| B | THR134 |
| B | ALA135 |
| B | THR136 |
| B | GLY137 |
| B | LYS138 |
| B | HOH468 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue IPA C 301 |
| Chain | Residue |
| C | CYS120 |
| C | HOH475 |
| C | HOH535 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue IPA C 302 |
| Chain | Residue |
| C | PRO7 |
| C | THR43 |
| C | THR44 |
| C | TYR130 |
| C | TYR132 |
| C | VAL157 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL C 303 |
| Chain | Residue |
| C | GLY240 |
| C | SER241 |
| C | LEU242 |
| C | SER243 |
| C | PRO263 |
| D | ARG106 |
| D | MET107 |
| D | SER108 |
| D | HIS111 |
| site_id | AD2 |
| Number of Residues | 16 |
| Details | binding site for residue PGE C 304 |
| Chain | Residue |
| C | TYR103 |
| C | TYR104 |
| C | THR134 |
| C | ALA135 |
| C | THR136 |
| C | GLY137 |
| C | LYS138 |
| C | HOH460 |
| D | TYR103 |
| D | TYR104 |
| D | THR134 |
| D | ALA135 |
| D | THR136 |
| D | GLY137 |
| D | LYS138 |
| D | HOH475 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue IPA D 301 |
| Chain | Residue |
| D | VAL157 |
| D | LEU198 |
| D | PRO7 |
| D | THR43 |
| D | THR44 |
| D | TYR130 |
| D | TYR132 |
| site_id | AD4 |
| Number of Residues | 10 |
| Details | binding site for residue GOL D 302 |
| Chain | Residue |
| C | ARG106 |
| C | MET107 |
| C | SER108 |
| C | HIS111 |
| D | GLY240 |
| D | SER241 |
| D | LEU242 |
| D | SER243 |
| D | PRO263 |
| D | ILE264 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL D 303 |
| Chain | Residue |
| D | CYS120 |
| D | HIS125 |
| D | CYS150 |
| D | HOH410 |
| D | HOH439 |
| D | HOH478 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 304 |
| Chain | Residue |
| A | ASP90 |
| A | PHE91 |
| D | SER51 |
| D | GLU54 |
| D | GLU57 |
| D | HOH419 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Schiff-base intermediate with substrate => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS155 | |
| B | LYS155 | |
| C | LYS155 | |
| D | LYS155 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | THR43 | |
| D | THR43 | |
| D | TYR130 | |
| D | LYS155 | |
| A | TYR130 | |
| A | LYS155 | |
| B | THR43 | |
| B | TYR130 | |
| B | LYS155 | |
| C | THR43 | |
| C | TYR130 | |
| C | LYS155 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Proton shuttle => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR130 | |
| B | TYR130 | |
| C | TYR130 | |
| D | TYR130 |
