6H1C
Structure of Ferric uptake regulator from Pseudomonas aeruginosa with manganese.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008198 | molecular_function | ferrous iron binding |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0019290 | biological_process | siderophore biosynthetic process |
| A | 0032993 | cellular_component | protein-DNA complex |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1900705 | biological_process | negative regulation of siderophore biosynthetic process |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0001217 | molecular_function | DNA-binding transcription repressor activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0008198 | molecular_function | ferrous iron binding |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0019290 | biological_process | siderophore biosynthetic process |
| B | 0032993 | cellular_component | protein-DNA complex |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0046872 | molecular_function | metal ion binding |
| B | 1900705 | biological_process | negative regulation of siderophore biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue MN A 201 |
| Chain | Residue |
| A | HIS32 |
| A | GLU80 |
| A | HIS89 |
| A | GLU100 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue MN A 202 |
| Chain | Residue |
| A | ASP88 |
| A | GLU107 |
| A | HOH314 |
| A | HOH333 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue MN A 203 |
| Chain | Residue |
| A | MN204 |
| B | ASP73 |
| B | HIS76 |
| A | GLU36 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue MN A 204 |
| Chain | Residue |
| A | GLU36 |
| A | MN203 |
| B | ASP73 |
| B | HIS76 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue MN A 205 |
| Chain | Residue |
| A | GLU105 |
| A | GLU105 |
| A | HOH332 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 206 |
| Chain | Residue |
| A | ASP73 |
| A | HIS76 |
| B | GLU36 |
| B | MN201 |
| B | MN202 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue MN A 207 |
| Chain | Residue |
| A | HIS70 |
| A | MN208 |
| A | HOH339 |
| A | HOH352 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue MN A 208 |
| Chain | Residue |
| A | HIS70 |
| A | MN207 |
| A | HOH352 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 209 |
| Chain | Residue |
| A | VAL2 |
| A | GLU3 |
| A | ASN4 |
| B | ZN208 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 210 |
| Chain | Residue |
| A | HIS87 |
| A | ASP123 |
| A | ALA124 |
| A | ASN125 |
| A | ZN211 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue ZN A 211 |
| Chain | Residue |
| A | HIS87 |
| A | ASP123 |
| A | ZN210 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue ZN A 212 |
| Chain | Residue |
| A | ASP83 |
| A | GLU100 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue MN B 201 |
| Chain | Residue |
| A | GLY75 |
| A | MN206 |
| B | MN202 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue MN B 202 |
| Chain | Residue |
| A | ASP73 |
| A | HIS76 |
| A | MN206 |
| B | GLU36 |
| B | MN201 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue MN B 203 |
| Chain | Residue |
| B | GLU105 |
| B | GLU105 |
| B | ARG109 |
| B | ARG109 |
| B | ZN204 |
| B | ZN204 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 204 |
| Chain | Residue |
| B | GLU105 |
| B | GLU105 |
| B | MN203 |
| B | MN203 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 205 |
| Chain | Residue |
| B | HIS32 |
| B | GLU80 |
| B | HIS89 |
| B | GLU100 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue ZN B 206 |
| Chain | Residue |
| B | HIS70 |
| B | ASN125 |
| B | ZN207 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue ZN B 207 |
| Chain | Residue |
| B | HIS70 |
| B | ZN206 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 208 |
| Chain | Residue |
| A | GLU3 |
| A | ZN209 |
| A | HOH340 |
| B | MET1 |
| B | GLU3 |
| B | ASP26 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 209 |
| Chain | Residue |
| B | ASP88 |
| B | GLU107 |
| B | HOH303 |
| B | HOH304 |
| B | HOH347 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue ZN B 210 |
| Chain | Residue |
| B | HIS87 |
| B | ASP123 |
| B | ZN211 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 211 |
| Chain | Residue |
| B | HIS87 |
| B | ASP123 |
| B | ALA124 |
| B | ASN125 |
| B | ZN210 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | HIS32 | |
| A | GLU80 | |
| A | HIS89 | |
| A | GLU100 | |
| B | HIS32 | |
| B | GLU80 | |
| B | HIS89 | |
| B | GLU100 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | ALA86 | |
| A | ASP88 | |
| A | GLU107 | |
| A | ALA124 | |
| B | ALA86 | |
| B | ASP88 | |
| B | GLU107 | |
| B | ALA124 |
