6H0Z

Crystal Structure of KDM4D with tetrazolylhydrazide ligand NR067

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	CYS238
A	HIS244
A	CYS310
A	CYS312

---

site_id	AC2
Number of Residues	2
Details	binding site for residue CL A 402

Chain	Residue
A	ASN128
A	LYS186

---

site_id	AC3
Number of Residues	5
Details	binding site for residue NA A 403

Chain	Residue
A	HOH660
A	HOH804
A	ASN17
A	ASN262
A	HOH614

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 404

Chain	Residue
A	ARG123
A	LYS124
A	LYS127
A	ASN128
A	HOH745

---

site_id	AC5
Number of Residues	8
Details	binding site for residue EDO A 405

Chain	Residue
A	LYS150
A	GLN151
A	TRP152
A	ASN153
A	HIS156
A	HOH707
A	HOH715
A	HOH819

---

site_id	AC6
Number of Residues	4
Details	binding site for residue EDO A 406

Chain	Residue
A	PRO251
A	THR252
A	LYS255
A	ARG263

---

site_id	AC7
Number of Residues	8
Details	binding site for residue EDO A 407

Chain	Residue
A	TYR179
A	TYR181
A	GLU194
A	SER200
A	ILE293
A	ASN294
A	FHQ412
A	HOH732

---

site_id	AC8
Number of Residues	7
Details	binding site for residue SO4 A 408

Chain	Residue
A	ARG60
A	THR62
A	ASN65
A	HOH519
A	HOH523
A	HOH531
A	HOH782

---

site_id	AC9
Number of Residues	11
Details	binding site for residue SO4 A 409

Chain	Residue
A	MET19
A	ILE20
A	LYS255
A	HOH502
A	HOH589
A	HOH604
A	HOH648
A	HOH696
A	HOH722
A	HOH816
A	HOH899

---

site_id	AD1
Number of Residues	5
Details	binding site for residue NI A 410

Chain	Residue
A	HIS192
A	GLU194
A	HIS280
A	FHQ412
A	HOH729

---

site_id	AD2
Number of Residues	15
Details	binding site for residue FHQ A 411

Chain	Residue
A	TYR63
A	ARG102
A	ALA105
A	ASN106
A	GLN111
A	THR112
A	GLY207
A	GLU208
A	GLY286
A	PHE287
A	HOH508
A	HOH572
A	HOH616
A	HOH675
A	HOH772

---

site_id	AD3
Number of Residues	15
Details	binding site for residue FHQ A 412

Chain	Residue
A	TYR136
A	PHE189
A	HIS192
A	GLU194
A	SER200
A	ASN202
A	LYS210
A	TRP212
A	HIS280
A	EDO407
A	NI410
A	HOH691
A	HOH729
A	HOH755
A	HOH850

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	166
Details	Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"B2RXH2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PDB","id":"5F5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"PubMed","id":"23102699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---