Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6GVE

GAPDH-CP12-PRK complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A	0006006	biological_process	glucose metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0046872	molecular_function	metal ion binding
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005975	biological_process	carbohydrate metabolic process
B	0008974	molecular_function	phosphoribulokinase activity
B	0015979	biological_process	photosynthesis
B	0016301	molecular_function	kinase activity
B	0019253	biological_process	reductive pentose-phosphate cycle
C	0080153	biological_process	negative regulation of reductive pentose-phosphate cycle
D	0000166	molecular_function	nucleotide binding
D	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D	0006006	biological_process	glucose metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0046872	molecular_function	metal ion binding
D	0050661	molecular_function	NADP binding
D	0051287	molecular_function	NAD binding
E	0000166	molecular_function	nucleotide binding
E	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E	0006006	biological_process	glucose metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0046872	molecular_function	metal ion binding
E	0050661	molecular_function	NADP binding
E	0051287	molecular_function	NAD binding
F	0000166	molecular_function	nucleotide binding
F	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F	0006006	biological_process	glucose metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0046872	molecular_function	metal ion binding
F	0050661	molecular_function	NADP binding
F	0051287	molecular_function	NAD binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005975	biological_process	carbohydrate metabolic process
G	0008974	molecular_function	phosphoribulokinase activity
G	0015979	biological_process	photosynthesis
G	0016301	molecular_function	kinase activity
G	0019253	biological_process	reductive pentose-phosphate cycle
H	0080153	biological_process	negative regulation of reductive pentose-phosphate cycle
I	0000166	molecular_function	nucleotide binding
I	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I	0006006	biological_process	glucose metabolic process
I	0016491	molecular_function	oxidoreductase activity
I	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
I	0046872	molecular_function	metal ion binding
I	0050661	molecular_function	NADP binding
I	0051287	molecular_function	NAD binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005975	biological_process	carbohydrate metabolic process
J	0008974	molecular_function	phosphoribulokinase activity
J	0015979	biological_process	photosynthesis
J	0016301	molecular_function	kinase activity
J	0019253	biological_process	reductive pentose-phosphate cycle
K	0000166	molecular_function	nucleotide binding
K	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K	0006006	biological_process	glucose metabolic process
K	0016491	molecular_function	oxidoreductase activity
K	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
K	0046872	molecular_function	metal ion binding
K	0050661	molecular_function	NADP binding
K	0051287	molecular_function	NAD binding
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0005975	biological_process	carbohydrate metabolic process
L	0008974	molecular_function	phosphoribulokinase activity
L	0015979	biological_process	photosynthesis
L	0016301	molecular_function	kinase activity
L	0019253	biological_process	reductive pentose-phosphate cycle
M	0080153	biological_process	negative regulation of reductive pentose-phosphate cycle
N	0000166	molecular_function	nucleotide binding
N	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N	0006006	biological_process	glucose metabolic process
N	0016491	molecular_function	oxidoreductase activity
N	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
N	0046872	molecular_function	metal ion binding
N	0050661	molecular_function	NADP binding
N	0051287	molecular_function	NAD binding
O	0000166	molecular_function	nucleotide binding
O	0004365	molecular_function	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O	0006006	biological_process	glucose metabolic process
O	0016491	molecular_function	oxidoreductase activity
O	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
O	0046872	molecular_function	metal ion binding
O	0050661	molecular_function	NADP binding
O	0051287	molecular_function	NAD binding
P	0080153	biological_process	negative regulation of reductive pentose-phosphate cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue NAD D 1001

Chain	Residue
A	SER193
D	ALA99
D	THR100
D	GLY101
D	VAL102
D	THR123
D	CYS154
D	ASN317
D	GLU318
D	TYR321
P	ASP66
D	GLY8
P	TYR73
P	ASP75
D	GLY10
D	ARG11
D	ILE12
D	ASP36
D	THR37
D	ASP80
D	ARG81

site_id	AC2
Number of Residues	18
Details	binding site for residue NAD A 1001

Chain	Residue
A	GLY8
A	GLY10
A	ARG11
A	ILE12
A	ASP36
A	THR37
A	ASP80
A	ARG81
A	ALA99
A	THR100
A	GLY101
A	VAL102
A	THR123
A	CYS154
A	ASN317
A	GLU318
A	TYR321
P	GLU69

site_id	AC3
Number of Residues	20
Details	binding site for residue NAD E 1001

Chain	Residue
C	ASP66
C	TYR73
C	ASP75
E	GLY8
E	GLY10
E	ARG11
E	ILE12
E	ASP36
E	THR37
E	ASP80
E	ARG81
E	ALA99
E	THR100
E	GLY101
E	VAL102
E	THR123
E	CYS154
E	ASN317
E	GLU318
E	TYR321

site_id	AC4
Number of Residues	18
Details	binding site for residue NAD F 1001

Chain	Residue
C	GLU69
F	GLY8
F	GLY10
F	ARG11
F	ILE12
F	ASP36
F	THR37
F	ASP80
F	ARG81
F	ALA99
F	THR100
F	GLY101
F	VAL102
F	THR123
F	CYS154
F	ASN317
F	GLU318
F	TYR321

site_id	AC5
Number of Residues	21
Details	binding site for residue NAD I 1001

Chain	Residue
H	ASP66
H	TYR73
H	ASP75
I	GLY8
I	GLY10
I	ARG11
I	ILE12
I	ASP36
I	THR37
I	ASP80
I	ARG81
I	ALA99
I	THR100
I	GLY101
I	VAL102
I	THR123
I	CYS154
I	ASN317
I	GLU318
I	TYR321
K	SER193

site_id	AC6
Number of Residues	18
Details	binding site for residue NAD K 1001

Chain	Residue
K	GLY8
K	GLY10
K	ARG11
K	ILE12
K	ASP36
K	THR37
K	ASP80
K	ARG81
K	ALA99
K	THR100
K	GLY101
K	VAL102
K	THR123
K	CYS154
K	ASN317
K	GLU318
K	TYR321
H	GLU69

site_id	AC7
Number of Residues	20
Details	binding site for residue NAD N 1001

Chain	Residue
M	ASP66
M	TYR73
M	ASP75
N	GLY8
N	GLY10
N	ARG11
N	ILE12
N	ASP36
N	THR37
N	ASP80
N	ARG81
N	ALA99
N	THR100
N	GLY101
N	VAL102
N	THR123
N	CYS154
N	ASN317
N	GLU318
N	TYR321

site_id	AC8
Number of Residues	18
Details	binding site for residue NAD O 1001

Chain	Residue
M	GLU69
O	GLY8
O	GLY10
O	ARG11
O	ILE12
O	ASP36
O	THR37
O	ASP80
O	ARG81
O	ALA99
O	THR100
O	GLY101
O	VAL102
O	THR123
O	CYS154
O	ASN317
O	GLU318
O	TYR321

Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL

Chain	Residue	Details
D	ALA152-LEU159

site_id	PS00567
Number of Residues	14
Details	PHOSPHORIBULOKINASE Phosphoribulokinase signature. KIkRDmaeRGhSyE

Chain	Residue	Details
J	LYS142-GLU155

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)