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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6GT3

Crystal Structure of the A2A-StaR2-bRIL562 in complex with AZD4635 at 2.0A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001609	molecular_function	G protein-coupled adenosine receptor activity
A	0001973	biological_process	G protein-coupled adenosine receptor signaling pathway
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005506	molecular_function	iron ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue NA A 2400

Chain	Residue
A	ASP52
A	SER91
A	HOH2514
A	HOH2574
A	HOH2582

site_id	AC2
Number of Residues	14
Details	binding site for residue F9Q A 2401

Chain	Residue
A	MET177
A	TRP246
A	LEU249
A	HIS250
A	ASN253
A	HIS278
A	HOH2529
A	HOH2561
A	HOH2573
A	HOH2593
A	ILE66
A	LEU85
A	PHE168
A	GLU169

site_id	AC3
Number of Residues	9
Details	binding site for residue CLR A 2402

Chain	Residue
A	ALA72
A	ALA73
A	GLY76
A	ILE80
A	CLR2404
A	OLC2422
A	OLC2427
A	OLC2428
A	HOH2533

site_id	AC4
Number of Residues	6
Details	binding site for residue CLR A 2403

Chain	Residue
A	LEU247
A	PRO248
A	SER263
A	OLA2406
A	OLA2412
A	HOH2520

site_id	AC5
Number of Residues	10
Details	binding site for residue CLR A 2404

Chain	Residue
A	LEU187
A	CYS254
A	PHE255
A	PHE258
A	CYS259
A	CLR2402
A	OLA2419
A	OLC2422
A	OLC2427
A	HOH2542

site_id	AC6
Number of Residues	2
Details	binding site for residue OLA A 2405

Chain	Residue
A	THR65
A	OLC2427

site_id	AC7
Number of Residues	1
Details	binding site for residue OLA A 2406

Chain	Residue
A	CLR2403

site_id	AC8
Number of Residues	2
Details	binding site for residue OLA A 2407

Chain	Residue
A	LEU241
A	LEU244

site_id	AC9
Number of Residues	4
Details	binding site for residue OLA A 2408

Chain	Residue
A	PHE44
A	ALA97
A	VAL116
A	HOH2504

site_id	AD1
Number of Residues	2
Details	binding site for residue OLA A 2409

Chain	Residue
A	THR279
A	PHE286

site_id	AD2
Number of Residues	3
Details	binding site for residue OLA A 2410

Chain	Residue
A	TYR271
A	VAL275
A	TYR290

site_id	AD3
Number of Residues	7
Details	binding site for residue OLA A 2411

Chain	Residue
A	ILE127
A	LEU131
A	CYS185
A	PRO189
A	VAL196
A	OLA2416
A	OLC2421

site_id	AD4
Number of Residues	1
Details	binding site for residue OLA A 2412

Chain	Residue
A	CLR2403

site_id	AD5
Number of Residues	5
Details	binding site for residue OLA A 2413

Chain	Residue
A	SER7
A	LEU19
A	TRP29
A	PHE286
A	HOH2575

site_id	AD6
Number of Residues	2
Details	binding site for residue OLA A 2415

Chain	Residue
A	ILE3
A	OLA2417

site_id	AD7
Number of Residues	2
Details	binding site for residue OLA A 2416

Chain	Residue
A	VAL130
A	OLA2411

site_id	AD8
Number of Residues	4
Details	binding site for residue OLA A 2417

Chain	Residue
A	SER6
A	LEU14
A	THR68
A	OLA2415

site_id	AD9
Number of Residues	3
Details	binding site for residue OLA A 2418

Chain	Residue
A	TRP32
A	PHE201
A	LYS233

site_id	AE1
Number of Residues	3
Details	binding site for residue OLA A 2419

Chain	Residue
A	ALA236
A	ALA239
A	CLR2404

site_id	AE2
Number of Residues	5
Details	binding site for residue OLC A 2420

Chain	Residue
A	TYR179
A	PHE258
A	OLC2421
A	OLC2422
A	HOH2557

site_id	AE3
Number of Residues	14
Details	binding site for residue OLC A 2421

Chain	Residue
A	OLA2411
A	OLC2420
A	OLC2426
A	HOH2503
A	HOH2536
A	HIS75
A	ALA134
A	MET140
A	LEU141
A	GLY142
A	ASN144
A	ASN175
A	TYR179
A	ALA184

site_id	AE4
Number of Residues	5
Details	binding site for residue OLC A 2422

Chain	Residue
A	PHE258
A	CLR2402
A	CLR2404
A	OLC2420
A	HOH2542

site_id	AE5
Number of Residues	4
Details	binding site for residue OLC A 2423

Chain	Residue
A	ALA202
A	ARG205
A	OLC2428
A	OLC2429

site_id	AE6
Number of Residues	4
Details	binding site for residue OLC A 2424

Chain	Residue
A	ALA73
A	CYS74
A	HIS75
A	GLY162

site_id	AE7
Number of Residues	5
Details	binding site for residue OLC A 2425

Chain	Residue
A	PHE255
A	ASP261
A	CYS262
A	OLC2427
A	HOH2520

site_id	AE8
Number of Residues	5
Details	binding site for residue OLC A 2426

Chain	Residue
A	PHE133
A	MET140
A	LEU141
A	OLC2421
A	HOH2541

site_id	AE9
Number of Residues	8
Details	binding site for residue OLC A 2427

Chain	Residue
A	THR65
A	CYS71
A	CYS259
A	CLR2402
A	CLR2404
A	OLA2405
A	OLC2425
A	HOH2596

site_id	AF1
Number of Residues	10
Details	binding site for residue OLC A 2428

Chain	Residue
A	TYR43
A	LEU54
A	LEU58
A	PHE83
A	GLY118
A	ILE125
A	TRP129
A	CLR2402
A	OLC2423
A	OLC2429

site_id	AF2
Number of Residues	7
Details	binding site for residue OLC A 2429

Chain	Residue
A	CYS28
A	TRP32
A	TYR43
A	ALA50
A	ARG205
A	OLC2423
A	OLC2428

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIfSLLAIAIDRYIaI

Chain	Residue	Details
A	SER90-ILE106

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	VAL8-TRP32

site_id	SWS_FT_FI2
Number of Residues	28
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:18832607

Chain	Residue	Details
A	LEU33-ASN42
A	ASP101-ARG120

site_id	SWS_FT_FI3
Number of Residues	23
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	TYR43-ILE66

site_id	SWS_FT_FI4
Number of Residues	46
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:18832607

Chain	Residue	Details
A	SER67-CYS77
A	ASN144-PRO173
A	CYS259-PRO266

site_id	SWS_FT_FI5
Number of Residues	22
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	LEU78-ILE100

site_id	SWS_FT_FI6
Number of Residues	22
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	ALA121-TRP143

site_id	SWS_FT_FI7
Number of Residues	24
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	MET174-LEU198

site_id	SWS_FT_FI8
Number of Residues	23
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	ALA235-PHE258

site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	LEU267-TYR290

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:21593763, ECO:0007744\|PDB:2YDO

Chain	Residue	Details
A	GLU169
A	ASN253
A	ALA277
A	HIS278

site_id	SWS_FT_FI11
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ALA154

site_id	SWS_FT_FI12
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
A	TRP1007
A	ILE1102

219140

PDB entries from 2024-05-01

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