Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6GQY

KRAS-169 Q61H GPPNHP + CH-3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
B	0007165	biological_process	signal transduction
B	0016020	cellular_component	membrane
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
C	0007165	biological_process	signal transduction
C	0016020	cellular_component	membrane
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
D	0007165	biological_process	signal transduction
D	0016020	cellular_component	membrane
E	0003924	molecular_function	GTPase activity
E	0005525	molecular_function	GTP binding
E	0007165	biological_process	signal transduction
E	0016020	cellular_component	membrane
F	0003924	molecular_function	GTPase activity
F	0005525	molecular_function	GTP binding
F	0007165	biological_process	signal transduction
F	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG A 201

Chain	Residue
A	SER17
A	THR35
A	ASP57
A	THR58
A	GNP202
A	HOH301

site_id	AC2
Number of Residues	24
Details	binding site for residue GNP A 202

Chain	Residue
A	GLY15
A	LYS16
A	SER17
A	ALA18
A	PHE28
A	VAL29
A	ASP30
A	TYR32
A	PRO34
A	THR35
A	GLY60
A	ASN116
A	LYS117
A	ASP119
A	LEU120
A	SER145
A	ALA146
A	LYS147
A	MG201
A	HOH301
A	HOH303
A	GLY12
A	GLY13
A	VAL14

site_id	AC3
Number of Residues	12
Details	binding site for residue F8Q A 203

Chain	Residue
A	LYS5
A	LEU6
A	SER39
A	TYR40
A	ARG41
A	ASP54
A	TYR71
A	THR74
B	ARG102
B	GLU107
C	GLY0
C	MET1

site_id	AC4
Number of Residues	5
Details	binding site for residue MG B 201

Chain	Residue
B	SER17
B	ASP33
B	THR35
B	GNP202
B	HOH301

site_id	AC5
Number of Residues	24
Details	binding site for residue GNP B 202

Chain	Residue
B	GLY12
B	GLY13
B	VAL14
B	GLY15
B	LYS16
B	SER17
B	ALA18
B	PHE28
B	VAL29
B	ASP30
B	TYR32
B	PRO34
B	THR35
B	GLY60
B	ASN116
B	LYS117
B	ASP119
B	LEU120
B	SER145
B	ALA146
B	LYS147
B	MG201
B	HOH301
B	HOH303

site_id	AC6
Number of Residues	11
Details	binding site for residue F8Q B 203

Chain	Residue
B	LYS5
B	LEU6
B	SER39
B	TYR40
B	ARG41
B	ASP54
B	ILE55
B	TYR71
B	THR74
E	GLY0
E	GLU3

site_id	AC7
Number of Residues	5
Details	binding site for residue MG C 201

Chain	Residue
C	SER17
C	THR35
C	ASP57
C	THR58
C	GNP202

site_id	AC8
Number of Residues	22
Details	binding site for residue GNP C 202

Chain	Residue
C	GLY60
C	ASN116
C	LYS117
C	ASP119
C	LEU120
C	SER145
C	ALA146
C	LYS147
C	MG201
C	HOH301
C	GLY12
C	GLY13
C	VAL14
C	GLY15
C	LYS16
C	SER17
C	ALA18
C	PHE28
C	VAL29
C	ASP30
C	TYR32
C	THR35

site_id	AC9
Number of Residues	7
Details	binding site for residue F8Q C 203

Chain	Residue
A	MET1
C	VAL7
C	SER39
C	ARG41
C	ASP54
C	TYR71
C	THR74

site_id	AD1
Number of Residues	5
Details	binding site for residue MG D 201

Chain	Residue
D	SER17
D	THR35
D	ASP57
D	THR58
D	GNP202

site_id	AD2
Number of Residues	21
Details	binding site for residue GNP D 202

Chain	Residue
D	GLY12
D	GLY13
D	VAL14
D	GLY15
D	LYS16
D	SER17
D	ALA18
D	PHE28
D	VAL29
D	ASP30
D	PRO34
D	THR35
D	GLY60
D	ASN116
D	LYS117
D	ASP119
D	LEU120
D	SER145
D	ALA146
D	LYS147
D	MG201

site_id	AD3
Number of Residues	9
Details	binding site for residue F8Q D 203

Chain	Residue
D	LYS5
D	SER39
D	ARG41
D	LEU56
D	TYR71
D	THR74
F	GLN-1
F	GLY0
F	GLU3

site_id	AD4
Number of Residues	5
Details	binding site for residue MG E 201

Chain	Residue
E	SER17
E	THR35
E	ASP57
E	THR58
E	GNP202

site_id	AD5
Number of Residues	21
Details	binding site for residue GNP E 202

Chain	Residue
E	GLY12
E	GLY13
E	VAL14
E	GLY15
E	LYS16
E	SER17
E	ALA18
E	PHE28
E	VAL29
E	ASP30
E	TYR32
E	THR35
E	GLY60
E	ASN116
E	LYS117
E	ASP119
E	LEU120
E	SER145
E	ALA146
E	LYS147
E	MG201

site_id	AD6
Number of Residues	5
Details	binding site for residue MG F 201

Chain	Residue
F	SER17
F	THR35
F	ASP57
F	THR58
F	GNP202

site_id	AD7
Number of Residues	21
Details	binding site for residue GNP F 202

Chain	Residue
F	GLY12
F	GLY13
F	VAL14
F	GLY15
F	LYS16
F	SER17
F	ALA18
F	PHE28
F	VAL29
F	ASP30
F	TYR32
F	PRO34
F	THR35
F	ASN116
F	LYS117
F	ASP119
F	LEU120
F	SER145
F	ALA146
F	LYS147
F	MG201

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Motif: {"description":"Effector region"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	107
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"N-acetylmethionine; in GTPase KRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)