6GQM

Crystal structure of human c-KIT kinase domain in complex with a small molecule inhibitor, AZD3229

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
B	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	binding site for residue F8H A 1001

Chain	Residue
A	LEU595
A	THR670
A	GLU671
A	TYR672
A	CYS673
A	CYS674
A	TYR675
A	GLY676
A	LEU799
A	ILE808
A	CYS809
A	VAL603
A	ASP810
A	PHE811
A	HOH1121
A	HOH1168
A	HOH1182
A	ALA621
A	LYS623
A	GLU640
A	LEU644
A	LEU647
A	ILE653
A	VAL654

---

site_id	AC2
Number of Residues	2
Details	binding site for residue CL A 1002

Chain	Residue
A	PRO627
A	LYS904

---

site_id	AC3
Number of Residues	2
Details	binding site for residue CL A 1003

Chain	Residue
A	THR666
A	HOH1134

---

site_id	AC4
Number of Residues	23
Details	binding site for residue F8H B 1001

Chain	Residue
A	ASP762
B	LEU595
B	VAL603
B	ALA621
B	LYS623
B	GLU640
B	LEU644
B	LEU647
B	ILE653
B	VAL654
B	THR670
B	GLU671
B	TYR672
B	CYS673
B	CYS674
B	TYR675
B	GLY676
B	LEU799
B	CYS809
B	ASP810
B	PHE811
B	HOH1115
B	HOH1131

---

Functional Information from PROSITE/UniProt

site_id	PS00024
Number of Residues	16
Details	HEMOPEXIN Hemopexin domain signature. LPvkWmapEsIFNSVY

Chain	Residue	Details
A	LEU831-TYR846

---

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGAGAFGKVVeAtaqgliksdaamt.....VAVK

Chain	Residue	Details
A	LEU595-LYS623

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNILL

Chain	Residue	Details
A	CYS788-LEU800

---

site_id	PS00240
Number of Residues	14
Details	RECEPTOR_TYR_KIN_III Receptor tyrosine kinase class III signature. GnHeNIVNLLGACT

Chain	Residue	Details
A	GLY648-THR661

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP792
B	ASP792

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	BINDING:

Chain	Residue	Details
A	TYR568
B	LYS623
B	GLU671
B	ARG796
B	ASN797
B	ASP810
A	GLY596
A	LYS623
A	GLU671
A	ARG796
A	ASN797
A	ASP810
B	TYR568
B	GLY596

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000305|PubMed:20147452

Chain	Residue	Details
A	TYR553
A	HIS790
B	TYR553
B	HIS790

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12824176, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:21030588, ECO:0000269|PubMed:9038210

Chain	Residue	Details
A	TYR568
B	TYR568

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12824176, ECO:0000269|PubMed:9038210

Chain	Residue	Details
A	TYR570
B	TYR570

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:10377264, ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:20147452

Chain	Residue	Details
A	PHE763
B	PHE763

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19265199, ECO:0000269|PubMed:20147452, ECO:0000269|PubMed:9038210

Chain	Residue	Details
A	ALA781
B	ALA781

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine; by PKC/PRKCA => ECO:0000269|PubMed:7539802

Chain	Residue	Details
A	THR801
A	THR806
B	THR801
B	THR806

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:7539802

Chain	Residue	Details
A	SER821
B	SER821

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:20147452

Chain	Residue	Details
A	TYR823
B	TYR823

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:12878163

Chain	Residue	Details
A	SER891
B	SER891

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12878163, ECO:0000269|PubMed:20147452

Chain	Residue	Details
A	TYR900
B	TYR900

---