6GQD
Structure of human galactose-1-phosphate uridylyltransferase (GALT), with crystallization epitope mutations A21Y:A22T:T23P:R25L
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0006011 | biological_process | UDP-alpha-D-glucose metabolic process |
| A | 0006012 | biological_process | galactose metabolic process |
| A | 0006796 | biological_process | phosphate-containing compound metabolic process |
| A | 0008108 | molecular_function | UDP-glucose:hexose-1-phosphate uridylyltransferase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0019637 | biological_process | organophosphate metabolic process |
| A | 0033499 | biological_process | galactose catabolic process via UDP-galactose, Leloir pathway |
| A | 0046872 | molecular_function | metal ion binding |
| A | 1901135 | biological_process | carbohydrate derivative metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | GLU202 |
| A | HIS301 |
| A | HIS319 |
| A | HIS321 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 402 |
| Chain | Residue |
| A | HIS260 |
| A | HOH697 |
| A | HOH763 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | HOH517 |
| A | HOH518 |
| A | HOH641 |
| A | HOH755 |
| A | GLN188 |
| A | H2U404 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue H2U A 404 |
| Chain | Residue |
| A | PRO73 |
| A | ALA81 |
| A | PHE95 |
| A | ASN97 |
| A | ASP98 |
| A | CYS180 |
| A | HIS186 |
| A | GLN188 |
| A | EDO403 |
| A | HOH567 |
| A | HOH568 |
| A | HOH661 |
| A | HOH678 |
| A | HOH696 |
| A | HOH741 |
Functional Information from PROSITE/UniProt
| site_id | PS00117 |
| Number of Residues | 18 |
| Details | GAL_P_UDP_TRANSF_I Galactose-1-phosphate uridyl transferase family 1 active site signature. FENKGammGcsnpHPHcQ |
| Chain | Residue | Details |
| A | PHE171-GLN188 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Tele-UMP-histidine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10033","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27005423","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10033","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"27005423","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27005423","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27005423","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
