6GQD

Structure of human galactose-1-phosphate uridylyltransferase (GALT), with crystallization epitope mutations A21Y:A22T:T23P:R25L

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0006011	biological_process	UDP-alpha-D-glucose metabolic process
A	0006012	biological_process	galactose metabolic process
A	0008108	molecular_function	UDP-glucose:hexose-1-phosphate uridylyltransferase activity
A	0008270	molecular_function	zinc ion binding
A	0033499	biological_process	galactose catabolic process via UDP-galactose, Leloir pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	GLU202
A	HIS301
A	HIS319
A	HIS321

---

site_id	AC2
Number of Residues	3
Details	binding site for residue EDO A 402

Chain	Residue
A	HIS260
A	HOH697
A	HOH763

---

site_id	AC3
Number of Residues	6
Details	binding site for residue EDO A 403

Chain	Residue
A	HOH517
A	HOH518
A	HOH641
A	HOH755
A	GLN188
A	H2U404

---

site_id	AC4
Number of Residues	15
Details	binding site for residue H2U A 404

Chain	Residue
A	PRO73
A	ALA81
A	PHE95
A	ASN97
A	ASP98
A	CYS180
A	HIS186
A	GLN188
A	EDO403
A	HOH567
A	HOH568
A	HOH661
A	HOH678
A	HOH696
A	HOH741

---

Functional Information from PROSITE/UniProt

site_id	PS00117
Number of Residues	18
Details	GAL_P_UDP_TRANSF_I Galactose-1-phosphate uridyl transferase family 1 active site signature. FENKGammGcsnpHPHcQ

Chain	Residue	Details
A	PHE171-GLN188

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Tele-UMP-histidine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10033","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27005423","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10033","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"27005423","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27005423","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27005423","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---