Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6GOM

KRAS-169 Q61H GPPNHP + PPIN-1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
B	0007165	biological_process	signal transduction
B	0016020	cellular_component	membrane
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
C	0007165	biological_process	signal transduction
C	0016020	cellular_component	membrane
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
D	0007165	biological_process	signal transduction
D	0016020	cellular_component	membrane
E	0003924	molecular_function	GTPase activity
E	0005525	molecular_function	GTP binding
E	0007165	biological_process	signal transduction
E	0016020	cellular_component	membrane
F	0003924	molecular_function	GTPase activity
F	0005525	molecular_function	GTP binding
F	0007165	biological_process	signal transduction
F	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	binding site for residue GNP A 201

Chain	Residue
A	GLY12
A	ASP30
A	GLU31
A	PRO34
A	THR35
A	GLY60
A	ASN116
A	LYS117
A	ASP119
A	LEU120
A	SER145
A	GLY13
A	ALA146
A	MG202
A	HOH305
A	HOH326
A	HOH330
A	HOH336
A	HOH341
A	HOH374
A	HOH392
A	VAL14
A	GLY15
A	LYS16
A	SER17
A	ALA18
A	PHE28
A	VAL29

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 202

Chain	Residue
A	SER17
A	THR35
A	GNP201
A	HOH336
A	HOH341

site_id	AC3
Number of Residues	11
Details	binding site for residue CIT A 203

Chain	Residue
A	ARG123
A	ASP126
A	THR127
A	HOH308
A	HOH393
F	LYS88
F	GLU91
F	ASP92
F	HIS94
F	HIS95
F	HOH307

site_id	AC4
Number of Residues	11
Details	binding site for residue F6E A 204

Chain	Residue
A	LEU6
A	VAL7
A	SER39
A	TYR40
A	ASP54
A	ILE55
A	TYR71
A	THR74
B	LYS101
B	ARG102
C	HOH312

site_id	AC5
Number of Residues	5
Details	binding site for residue CIT A 205

Chain	Residue
A	HIS95
A	GLN99
A	ARG102
A	HOH310
A	HOH383

site_id	AC6
Number of Residues	28
Details	binding site for residue GNP B 201

Chain	Residue
B	GLY12
B	GLY13
B	VAL14
B	GLY15
B	LYS16
B	SER17
B	ALA18
B	PHE28
B	VAL29
B	ASP30
B	GLU31
B	PRO34
B	THR35
B	GLY60
B	ASN116
B	LYS117
B	ASP119
B	LEU120
B	SER145
B	ALA146
B	MG202
B	HOH308
B	HOH309
B	HOH316
B	HOH330
B	HOH340
B	HOH352
B	HOH409

site_id	AC7
Number of Residues	5
Details	binding site for residue MG B 202

Chain	Residue
B	SER17
B	THR35
B	GNP201
B	HOH309
B	HOH340

site_id	AC8
Number of Residues	7
Details	binding site for residue PO4 B 203

Chain	Residue
D	GLN150
A	THR148
A	GLN150
B	THR148
B	GLN150
B	HOH413
D	THR148

site_id	AC9
Number of Residues	21
Details	binding site for residue GNP C 201

Chain	Residue
C	GLY13
C	VAL14
C	GLY15
C	LYS16
C	SER17
C	ALA18
C	PHE28
C	VAL29
C	ASP30
C	GLU31
C	GLY60
C	ASN116
C	LYS117
C	ASP119
C	LEU120
C	SER145
C	ALA146
C	MG202
C	HOH301
C	HOH309
C	HOH355

site_id	AD1
Number of Residues	4
Details	binding site for residue MG C 202

Chain	Residue
C	SER17
C	GNP201
C	HOH301
C	HOH309

site_id	AD2
Number of Residues	20
Details	binding site for residue GNP D 201

Chain	Residue
D	GLY13
D	VAL14
D	GLY15
D	LYS16
D	SER17
D	ALA18
D	PHE28
D	VAL29
D	ASP30
D	GLU31
D	TYR32
D	GLY60
D	ASN116
D	LYS117
D	ASP119
D	LEU120
D	SER145
D	ALA146
D	MG202
D	HOH307

site_id	AD3
Number of Residues	3
Details	binding site for residue MG D 202

Chain	Residue
D	SER17
D	GNP201
D	HOH307

site_id	AD4
Number of Residues	3
Details	binding site for residue CIT D 203

Chain	Residue
D	HIS95
D	GLU98
D	ARG102

site_id	AD5
Number of Residues	25
Details	binding site for residue GNP E 201

Chain	Residue
E	GLY12
E	GLY13
E	VAL14
E	GLY15
E	LYS16
E	SER17
E	ALA18
E	PHE28
E	VAL29
E	ASP30
E	TYR32
E	PRO34
E	THR35
E	GLY60
E	ASN116
E	LYS117
E	ASP119
E	LEU120
E	SER145
E	ALA146
E	MG202
E	HOH307
E	HOH318
E	HOH321
E	HOH349

site_id	AD6
Number of Residues	5
Details	binding site for residue MG E 202

Chain	Residue
E	SER17
E	THR35
E	GNP201
E	HOH307
E	HOH318

site_id	AD7
Number of Residues	23
Details	binding site for residue GNP F 201

Chain	Residue
F	GLY13
F	VAL14
F	GLY15
F	LYS16
F	SER17
F	ALA18
F	PHE28
F	VAL29
F	ASP30
F	GLU31
F	GLY60
F	ASN116
F	LYS117
F	ASP119
F	LEU120
F	SER145
F	ALA146
F	MG202
F	HOH302
F	HOH335
F	HOH342
F	HOH347
F	HOH367

site_id	AD8
Number of Residues	4
Details	binding site for residue MG F 202

Chain	Residue
F	SER17
F	GNP201
F	HOH302
F	HOH347

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Motif: {"description":"Effector region"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	85
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"N-acetylmethionine; in GTPase KRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	3
Details	Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)