Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6GLR

Crystal structure of hMTH1 N33G in complex with TH scaffold 1 in the presence of acetate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006152	biological_process	purine nucleoside catabolic process
A	0006281	biological_process	DNA repair
A	0006979	biological_process	response to oxidative stress
A	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A	0008828	molecular_function	dATP diphosphatase activity
A	0016787	molecular_function	hydrolase activity
A	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
A	0030515	molecular_function	snoRNA binding
A	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A	0042262	biological_process	DNA protection
A	0046872	molecular_function	metal ion binding
A	0047693	molecular_function	ATP diphosphatase activity
A	0106377	molecular_function	2-hydroxy-ATP hydrolase activity
A	0106378	molecular_function	2-hydroxy-dATP hydrolase activity
A	0106431	molecular_function	N6-methyl-(d)ATP hydrolase activity
A	0106433	molecular_function	O6-methyl-dGTP hydrolase activity
A	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006152	biological_process	purine nucleoside catabolic process
B	0006281	biological_process	DNA repair
B	0006979	biological_process	response to oxidative stress
B	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
B	0008828	molecular_function	dATP diphosphatase activity
B	0016787	molecular_function	hydrolase activity
B	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B	0030515	molecular_function	snoRNA binding
B	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
B	0042262	biological_process	DNA protection
B	0046872	molecular_function	metal ion binding
B	0047693	molecular_function	ATP diphosphatase activity
B	0106377	molecular_function	2-hydroxy-ATP hydrolase activity
B	0106378	molecular_function	2-hydroxy-dATP hydrolase activity
B	0106431	molecular_function	N6-methyl-(d)ATP hydrolase activity
B	0106433	molecular_function	O6-methyl-dGTP hydrolase activity
B	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue F3E A 201

Chain	Residue
A	PHE72
A	MET81
A	TRP117
A	ASP119
A	ASP120
A	ACT203
A	HOH331

site_id	AC2
Number of Residues	8
Details	binding site for residue F3E A 202

Chain	Residue
A	GLU77
A	GLU79
A	MET81
A	SO4206
B	PRO15
B	ASP89
A	TYR7
A	PHE27

site_id	AC3
Number of Residues	8
Details	binding site for residue ACT A 203

Chain	Residue
A	LEU9
A	GLY33
A	GLY34
A	ASP120
A	TRP123
A	F3E201
A	HOH328
A	HOH331

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 204

Chain	Residue
A	HIS65
A	LYS66
A	HOH306

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 A 205

Chain	Residue
A	ARG151
A	HOH307
A	HOH332
B	THR44
B	ILE45

site_id	AC6
Number of Residues	8
Details	binding site for residue SO4 A 206

Chain	Residue
A	PHE27
A	F3E202
A	HOH402
A	HOH407
B	HIS65
B	THR88
B	ASP89
B	SER90

site_id	AC7
Number of Residues	6
Details	binding site for residue F3E B 201

Chain	Residue
B	PHE72
B	TRP117
B	ASP119
B	ASP120
B	ACT202
B	HOH324

site_id	AC8
Number of Residues	7
Details	binding site for residue ACT B 202

Chain	Residue
B	LEU9
B	GLY33
B	GLY34
B	ASP120
B	PHE124
B	F3E201
B	HOH324

site_id	AC9
Number of Residues	7
Details	binding site for residue ACT B 203

Chain	Residue
A	GLN107
A	ASP109
A	HOH340
A	HOH383
B	ARG5
B	HOH330
B	HOH357

site_id	AD1
Number of Residues	7
Details	binding site for residue SO4 B 204

Chain	Residue
A	THR44
A	ILE45
B	HIS134
B	ARG151
B	HOH320
B	HOH322
B	HOH358

site_id	AD2
Number of Residues	2
Details	binding site for residue SO4 B 205

Chain	Residue
B	HIS65
B	LYS66

site_id	AD3
Number of Residues	4
Details	binding site for residue SO4 B 206

Chain	Residue
B	ARG151
B	VAL153
B	ASP154
B	THR155

Functional Information from PROSITE/UniProt

site_id	PS00893
Number of Residues	22
Details	NUDIX_BOX Nudix box signature. GkvqegEtiedGArRELqEEsG

Chain	Residue	Details
A	GLY37-GLY58

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q7ZWC3

Chain	Residue	Details
A	LEU11
A	GLN14
A	PRO15
A	LEU59
B	LEU11
B	GLN14
B	PRO15
B	LEU59

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:30304478, ECO:0007744\|PDB:5OTM

Chain	Residue	Details
A	GLY76
B	GLY76

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)