6GKZ
Crystal structure of Coclaurine N-Methyltransferase (CNMT) bound to N-methylheliamine and SAH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0030776 | molecular_function | (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0030776 | molecular_function | (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity |
| B | 0032259 | biological_process | methylation |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0030776 | molecular_function | (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity |
| C | 0032259 | biological_process | methylation |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0030776 | molecular_function | (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity |
| D | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue SAH A 501 |
| Chain | Residue |
| A | GLY98 |
| A | ILE188 |
| A | ILE203 |
| A | LEU205 |
| A | HOH623 |
| A | SER99 |
| A | GLY137 |
| A | GLY139 |
| A | THR160 |
| A | ASN161 |
| A | GLN165 |
| A | ALA186 |
| A | ASP187 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue SAH B 501 |
| Chain | Residue |
| B | GLY98 |
| B | SER99 |
| B | GLY137 |
| B | CYS138 |
| B | GLY139 |
| B | THR160 |
| B | ASN161 |
| B | GLN165 |
| B | ALA186 |
| B | ASP187 |
| B | ILE188 |
| B | ILE203 |
| B | LEU205 |
| B | HOH635 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue SAH C 501 |
| Chain | Residue |
| C | GLY98 |
| C | SER99 |
| C | GLY137 |
| C | CYS138 |
| C | GLY139 |
| C | GLN165 |
| C | ALA186 |
| C | ASP187 |
| C | ILE188 |
| C | ILE203 |
| C | LEU205 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue SAH D 501 |
| Chain | Residue |
| D | GLY98 |
| D | SER99 |
| D | GLY137 |
| D | CYS138 |
| D | GLY139 |
| D | THR160 |
| D | ASN161 |
| D | GLN165 |
| D | ALA186 |
| D | ASP187 |
| D | ILE188 |
| D | ILE203 |
| D | LEU205 |
| D | HOH628 |
| D | HOH643 |
| D | HOH671 |
