6GKV

Crystal structure of Coclaurine N-Methyltransferase (CNMT) bound to N-methylheliamine and SAH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0030776	molecular_function	(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0030776	molecular_function	(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue SAH A 501

Chain	Residue
A	VAL73
A	ASP187
A	ILE188
A	ILE203
A	GLU204
A	LEU205
A	MET209
A	HOH603
A	TYR81
A	GLY98
A	SER99
A	GLY137
A	CYS138
A	GLY139
A	ASN161
A	GLN165

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site_id	AC2
Number of Residues	8
Details	binding site for residue F2W A 502

Chain	Residue
A	GLU204
A	PHE257
A	ILE264
A	ASN294
A	PHE332
A	GLY336
A	MET339
A	PHE340

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site_id	AC3
Number of Residues	8
Details	binding site for residue F2W B 401

Chain	Residue
B	GLU204
B	PHE257
B	MET262
B	PHE290
B	ASN294
B	PHE332
B	GLY336
B	PHE340

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site_id	AC4
Number of Residues	17
Details	binding site for residue SAH B 402

Chain	Residue
B	ASP77
B	TYR81
B	GLY98
B	SER99
B	GLY137
B	CYS138
B	GLY139
B	THR160
B	ASN161
B	GLN165
B	ALA186
B	ASP187
B	ILE188
B	THR189
B	ILE203
B	GLU204
B	HOH508

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