6GJ8

CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH BI 2852

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue F0K A 201

Chain	Residue
A	MET1
A	LEU52
A	LEU53
A	ASP54
A	LEU56
A	TYR71
A	THR74
A	GLY75
A	HOH314
A	HOH325
A	HOH398
A	GLU3
A	LYS5
A	VAL7
A	GLU37
A	SER39
A	ARG41
A	LYS42
A	GLN43

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site_id	AC2
Number of Residues	3
Details	binding site for residue MG A 202

Chain	Residue
A	SER17
A	THR35
A	GCP203

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site_id	AC3
Number of Residues	28
Details	binding site for residue GCP A 203

Chain	Residue
A	ALA11
A	ASP12
A	GLY13
A	VAL14
A	GLY15
A	LYS16
A	SER17
A	ALA18
A	PHE28
A	VAL29
A	ASP30
A	GLU31
A	TYR32
A	PRO34
A	THR35
A	GLY60
A	ASN116
A	LYS117
A	ASP119
A	LEU120
A	SER145
A	ALA146
A	MG202
A	HOH323
A	HOH329
A	HOH356
A	HOH453
A	HOH454

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140

Chain	Residue	Details
A	GLY10
A	VAL29
A	ALA59
A	ASN116

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269|Ref.17

Chain	Residue	Details
A	MET1

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269|Ref.17

Chain	Residue	Details
A	THR2

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22711838

Chain	Residue	Details
A	LYS104

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486

Chain	Residue	Details
A	THR35

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