6GJ0
Human IMPase with Mn
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006020 | biological_process | inositol metabolic process |
| A | 0006021 | biological_process | inositol biosynthetic process |
| A | 0006661 | biological_process | phosphatidylinositol biosynthetic process |
| A | 0006796 | biological_process | phosphate-containing compound metabolic process |
| A | 0007165 | biological_process | signal transduction |
| A | 0008934 | molecular_function | inositol monophosphate 1-phosphatase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0031403 | molecular_function | lithium ion binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046854 | biological_process | phosphatidylinositol phosphate biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052832 | molecular_function | inositol monophosphate 3-phosphatase activity |
| A | 0052833 | molecular_function | inositol monophosphate 4-phosphatase activity |
| A | 0052834 | molecular_function | inositol monophosphate phosphatase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006020 | biological_process | inositol metabolic process |
| B | 0006021 | biological_process | inositol biosynthetic process |
| B | 0006661 | biological_process | phosphatidylinositol biosynthetic process |
| B | 0006796 | biological_process | phosphate-containing compound metabolic process |
| B | 0007165 | biological_process | signal transduction |
| B | 0008934 | molecular_function | inositol monophosphate 1-phosphatase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0031403 | molecular_function | lithium ion binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046854 | biological_process | phosphatidylinositol phosphate biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052832 | molecular_function | inositol monophosphate 3-phosphatase activity |
| B | 0052833 | molecular_function | inositol monophosphate 4-phosphatase activity |
| B | 0052834 | molecular_function | inositol monophosphate phosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 301 |
| Chain | Residue |
| A | GLU70 |
| A | MES307 |
| A | HOH429 |
| A | HOH432 |
| A | HOH456 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 302 |
| Chain | Residue |
| A | HOH492 |
| A | GLU70 |
| A | ASP90 |
| A | ILE92 |
| A | MES307 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MN A 303 |
| Chain | Residue |
| A | ASP90 |
| A | ASP93 |
| A | ASP220 |
| A | GOL304 |
| A | MES307 |
| A | HOH528 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 304 |
| Chain | Residue |
| A | ASP93 |
| A | THR195 |
| A | ALA196 |
| A | GLU213 |
| A | ASP220 |
| A | MN303 |
| A | MES307 |
| A | HOH446 |
| A | HOH528 |
| A | HOH552 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 305 |
| Chain | Residue |
| A | LEU163 |
| A | SER192 |
| A | HOH407 |
| A | HOH411 |
| B | ILE190 |
| B | ARG191 |
| B | SER192 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 306 |
| Chain | Residue |
| A | ARG248 |
| A | LEU271 |
| A | GLN272 |
| A | HOH557 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | binding site for residue MES A 307 |
| Chain | Residue |
| A | GLU70 |
| A | ASP90 |
| A | ILE92 |
| A | ASP93 |
| A | GLY94 |
| A | THR95 |
| A | THR96 |
| A | MN301 |
| A | MN302 |
| A | MN303 |
| A | GOL304 |
| A | HOH426 |
| A | HOH489 |
| A | HOH528 |
| A | HOH574 |
| A | HOH585 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue MN B 301 |
| Chain | Residue |
| B | ASP90 |
| B | ASP93 |
| B | ASP220 |
| B | GOL304 |
| B | MES307 |
| B | HOH517 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue MN B 302 |
| Chain | Residue |
| B | GLU70 |
| B | ASP90 |
| B | ILE92 |
| B | MES307 |
| B | HOH472 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue MN B 303 |
| Chain | Residue |
| B | GLU70 |
| B | MES307 |
| B | HOH428 |
| B | HOH436 |
| B | HOH447 |
| site_id | AD2 |
| Number of Residues | 11 |
| Details | binding site for residue GOL B 304 |
| Chain | Residue |
| B | ASP93 |
| B | THR195 |
| B | ALA196 |
| B | GLU213 |
| B | ASP220 |
| B | MN301 |
| B | MES307 |
| B | HOH413 |
| B | HOH441 |
| B | HOH517 |
| B | HOH540 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 305 |
| Chain | Residue |
| A | VAL99 |
| A | HIS100 |
| B | GLN151 |
| B | LYS156 |
| B | HIS188 |
| B | ASP209 |
| B | HOH534 |
| B | HOH539 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 306 |
| Chain | Residue |
| B | VAL73 |
| B | LYS78 |
| B | SER79 |
| B | ASP277 |
| site_id | AD5 |
| Number of Residues | 19 |
| Details | binding site for residue MES B 307 |
| Chain | Residue |
| B | THR95 |
| B | THR96 |
| B | ASN97 |
| B | GLY194 |
| B | MN301 |
| B | MN302 |
| B | MN303 |
| B | GOL304 |
| B | HOH428 |
| B | HOH429 |
| B | HOH496 |
| B | HOH517 |
| A | ARG191 |
| A | HOH536 |
| B | GLU70 |
| B | ASP90 |
| B | ILE92 |
| B | ASP93 |
| B | GLY94 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:8068620, ECO:0000303|PubMed:8068621 |
| Chain | Residue | Details |
| A | GLU70 | |
| A | GLU213 | |
| B | GLU70 | |
| B | GLU213 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23027737, ECO:0000269|PubMed:8068621 |
| Chain | Residue | Details |
| A | ASP90 | |
| A | ASP93 | |
| B | ASP90 | |
| B | ASP93 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23027737, ECO:0000269|PubMed:8068621, ECO:0000303|PubMed:1332026, ECO:0000303|PubMed:8068620 |
| Chain | Residue | Details |
| A | ILE92 | |
| B | ILE92 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:8068620 |
| Chain | Residue | Details |
| A | GLY194 | |
| A | ASP220 | |
| B | GLY194 | |
| B | ASP220 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR168 | |
| B | THR168 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 577 |
| Chain | Residue | Details |
| A | GLU70 | metal ligand, proton acceptor, proton donor |
| A | ASP90 | metal ligand |
| A | ILE92 | metal ligand |
| A | ASP93 | metal ligand |
| A | THR95 | hydrogen bond acceptor |
| A | ASP220 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 577 |
| Chain | Residue | Details |
| B | GLU70 | metal ligand, proton acceptor, proton donor |
| B | ASP90 | metal ligand |
| B | ILE92 | metal ligand |
| B | ASP93 | metal ligand |
| B | THR95 | hydrogen bond acceptor |
| B | ASP220 | metal ligand |
