6GIQ

Saccharomyces cerevisiae respiratory supercomplex III2IV

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0004129	molecular_function	cytochrome-c oxidase activity
a	0005515	molecular_function	protein binding
a	0005739	cellular_component	mitochondrion
a	0005743	cellular_component	mitochondrial inner membrane
a	0005751	cellular_component	mitochondrial respiratory chain complex IV
a	0006119	biological_process	oxidative phosphorylation
a	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
a	0009060	biological_process	aerobic respiration
a	0015990	biological_process	electron transport coupled proton transport
a	0016020	cellular_component	membrane
a	0020037	molecular_function	heme binding
a	0031966	cellular_component	mitochondrial membrane
a	0045277	cellular_component	respiratory chain complex IV
a	0045333	biological_process	cellular respiration
a	0046872	molecular_function	metal ion binding
a	0070469	cellular_component	respirasome
A	0004222	molecular_function	metalloendopeptidase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005750	cellular_component	mitochondrial respiratory chain complex III
A	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
A	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
A	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
A	0009060	biological_process	aerobic respiration
A	0045333	biological_process	cellular respiration
A	0046872	molecular_function	metal ion binding
A	0070469	cellular_component	respirasome
A	1902600	biological_process	proton transmembrane transport
b	0004129	molecular_function	cytochrome-c oxidase activity
b	0005507	molecular_function	copper ion binding
b	0005515	molecular_function	protein binding
b	0005739	cellular_component	mitochondrion
b	0005743	cellular_component	mitochondrial inner membrane
b	0005751	cellular_component	mitochondrial respiratory chain complex IV
b	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
b	0009060	biological_process	aerobic respiration
b	0016020	cellular_component	membrane
b	0016491	molecular_function	oxidoreductase activity
b	0022900	biological_process	electron transport chain
b	0042773	biological_process	ATP synthesis coupled electron transport
b	0046872	molecular_function	metal ion binding
b	0070469	cellular_component	respirasome
b	1902600	biological_process	proton transmembrane transport
B	0004222	molecular_function	metalloendopeptidase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005750	cellular_component	mitochondrial respiratory chain complex III
B	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
B	0006508	biological_process	proteolysis
B	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
B	0009060	biological_process	aerobic respiration
B	0030061	cellular_component	mitochondrial crista
B	0045333	biological_process	cellular respiration
B	0046872	molecular_function	metal ion binding
B	0070469	cellular_component	respirasome
B	1902600	biological_process	proton transmembrane transport
c	0004129	molecular_function	cytochrome-c oxidase activity
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0005751	cellular_component	mitochondrial respiratory chain complex IV
c	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
c	0009055	molecular_function	electron transfer activity
c	0009060	biological_process	aerobic respiration
c	0016020	cellular_component	membrane
c	0019646	biological_process	aerobic electron transport chain
c	0022904	biological_process	respiratory electron transport chain
c	0031966	cellular_component	mitochondrial membrane
c	0045333	biological_process	cellular respiration
c	1902600	biological_process	proton transmembrane transport
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005750	cellular_component	mitochondrial respiratory chain complex III
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0009060	biological_process	aerobic respiration
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0022904	biological_process	respiratory electron transport chain
C	0045275	cellular_component	respiratory chain complex III
C	0045333	biological_process	cellular respiration
C	0046872	molecular_function	metal ion binding
C	0070469	cellular_component	respirasome
C	1902600	biological_process	proton transmembrane transport
d	0004129	molecular_function	cytochrome-c oxidase activity
d	0005739	cellular_component	mitochondrion
d	0005740	cellular_component	mitochondrial envelope
d	0005743	cellular_component	mitochondrial inner membrane
d	0005751	cellular_component	mitochondrial respiratory chain complex IV
d	0005758	cellular_component	mitochondrial intermembrane space
d	0006119	biological_process	oxidative phosphorylation
d	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
d	0008270	molecular_function	zinc ion binding
d	0016491	molecular_function	oxidoreductase activity
d	0033617	biological_process	mitochondrial cytochrome c oxidase assembly
d	0046872	molecular_function	metal ion binding
d	1902600	biological_process	proton transmembrane transport
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005750	cellular_component	mitochondrial respiratory chain complex III
D	0005758	cellular_component	mitochondrial intermembrane space
D	0005829	cellular_component	cytosol
D	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
D	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
D	0045333	biological_process	cellular respiration
D	0046872	molecular_function	metal ion binding
D	0070469	cellular_component	respirasome
D	1902600	biological_process	proton transmembrane transport
e	0004129	molecular_function	cytochrome-c oxidase activity
e	0005739	cellular_component	mitochondrion
e	0005743	cellular_component	mitochondrial inner membrane
e	0005751	cellular_component	mitochondrial respiratory chain complex IV
e	0005758	cellular_component	mitochondrial intermembrane space
e	0006119	biological_process	oxidative phosphorylation
e	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
e	0016491	molecular_function	oxidoreductase activity
e	1902600	biological_process	proton transmembrane transport
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005750	cellular_component	mitochondrial respiratory chain complex III
E	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
E	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
E	0009060	biological_process	aerobic respiration
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0045333	biological_process	cellular respiration
E	0046872	molecular_function	metal ion binding
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
E	0070469	cellular_component	respirasome
E	1902600	biological_process	proton transmembrane transport
f	0004129	molecular_function	cytochrome-c oxidase activity
f	0005739	cellular_component	mitochondrion
f	0005743	cellular_component	mitochondrial inner membrane
f	0005751	cellular_component	mitochondrial respiratory chain complex IV
f	0006119	biological_process	oxidative phosphorylation
f	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
f	0016491	molecular_function	oxidoreductase activity
f	0046872	molecular_function	metal ion binding
f	1902600	biological_process	proton transmembrane transport
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005750	cellular_component	mitochondrial respiratory chain complex III
F	0005758	cellular_component	mitochondrial intermembrane space
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
F	0009060	biological_process	aerobic respiration
F	0034399	cellular_component	nuclear periphery
F	0045333	biological_process	cellular respiration
F	0070469	cellular_component	respirasome
F	1902600	biological_process	proton transmembrane transport
g	0004129	molecular_function	cytochrome-c oxidase activity
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0005751	cellular_component	mitochondrial respiratory chain complex IV
g	0006119	biological_process	oxidative phosphorylation
g	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
g	0016491	molecular_function	oxidoreductase activity
g	0031966	cellular_component	mitochondrial membrane
g	0045333	biological_process	cellular respiration
g	1902600	biological_process	proton transmembrane transport
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005750	cellular_component	mitochondrial respiratory chain complex III
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
G	0009060	biological_process	aerobic respiration
G	0034551	biological_process	mitochondrial respiratory chain complex III assembly
G	0045333	biological_process	cellular respiration
G	0070469	cellular_component	respirasome
G	0099617	cellular_component	matrix side of mitochondrial inner membrane
G	1902600	biological_process	proton transmembrane transport
h	0004129	molecular_function	cytochrome-c oxidase activity
h	0005739	cellular_component	mitochondrion
h	0005743	cellular_component	mitochondrial inner membrane
h	0005751	cellular_component	mitochondrial respiratory chain complex IV
h	0006119	biological_process	oxidative phosphorylation
h	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
h	0016491	molecular_function	oxidoreductase activity
h	0045277	cellular_component	respiratory chain complex IV
h	1902600	biological_process	proton transmembrane transport
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005750	cellular_component	mitochondrial respiratory chain complex III
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
H	0009060	biological_process	aerobic respiration
H	0045333	biological_process	cellular respiration
H	0070469	cellular_component	respirasome
H	1902600	biological_process	proton transmembrane transport
i	0004129	molecular_function	cytochrome-c oxidase activity
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0005751	cellular_component	mitochondrial respiratory chain complex IV
i	0006119	biological_process	oxidative phosphorylation
i	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
i	0016491	molecular_function	oxidoreductase activity
i	1902600	biological_process	proton transmembrane transport
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0005750	cellular_component	mitochondrial respiratory chain complex III
I	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
I	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
I	0009060	biological_process	aerobic respiration
I	0034551	biological_process	mitochondrial respiratory chain complex III assembly
I	0045333	biological_process	cellular respiration
I	0070469	cellular_component	respirasome
I	1902600	biological_process	proton transmembrane transport
j	0004129	molecular_function	cytochrome-c oxidase activity
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0005751	cellular_component	mitochondrial respiratory chain complex IV
j	0005758	cellular_component	mitochondrial intermembrane space
j	0006119	biological_process	oxidative phosphorylation
j	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
j	0016491	molecular_function	oxidoreductase activity
j	0031966	cellular_component	mitochondrial membrane
j	0033617	biological_process	mitochondrial cytochrome c oxidase assembly
j	0045277	cellular_component	respiratory chain complex IV
j	0045333	biological_process	cellular respiration
j	1902600	biological_process	proton transmembrane transport
k	0004129	molecular_function	cytochrome-c oxidase activity
k	0005739	cellular_component	mitochondrion
k	0005743	cellular_component	mitochondrial inner membrane
k	0005751	cellular_component	mitochondrial respiratory chain complex IV
k	0006119	biological_process	oxidative phosphorylation
k	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
k	0009060	biological_process	aerobic respiration
k	0016491	molecular_function	oxidoreductase activity
k	0030234	molecular_function	enzyme regulator activity
k	0097250	biological_process	mitochondrial respirasome assembly
k	1902600	biological_process	proton transmembrane transport
L	0004222	molecular_function	metalloendopeptidase activity
L	0005515	molecular_function	protein binding
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005750	cellular_component	mitochondrial respiratory chain complex III
L	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
L	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
L	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
L	0009060	biological_process	aerobic respiration
L	0045333	biological_process	cellular respiration
L	0046872	molecular_function	metal ion binding
L	0070469	cellular_component	respirasome
L	1902600	biological_process	proton transmembrane transport
M	0004222	molecular_function	metalloendopeptidase activity
M	0005515	molecular_function	protein binding
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005750	cellular_component	mitochondrial respiratory chain complex III
M	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
M	0006508	biological_process	proteolysis
M	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
M	0009060	biological_process	aerobic respiration
M	0030061	cellular_component	mitochondrial crista
M	0045333	biological_process	cellular respiration
M	0046872	molecular_function	metal ion binding
M	0070469	cellular_component	respirasome
M	1902600	biological_process	proton transmembrane transport
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005750	cellular_component	mitochondrial respiratory chain complex III
N	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
N	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
N	0009055	molecular_function	electron transfer activity
N	0009060	biological_process	aerobic respiration
N	0016020	cellular_component	membrane
N	0016491	molecular_function	oxidoreductase activity
N	0022904	biological_process	respiratory electron transport chain
N	0045275	cellular_component	respiratory chain complex III
N	0045333	biological_process	cellular respiration
N	0046872	molecular_function	metal ion binding
N	0070469	cellular_component	respirasome
N	1902600	biological_process	proton transmembrane transport
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0005750	cellular_component	mitochondrial respiratory chain complex III
O	0005758	cellular_component	mitochondrial intermembrane space
O	0005829	cellular_component	cytosol
O	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
O	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
O	0009055	molecular_function	electron transfer activity
O	0020037	molecular_function	heme binding
O	0045333	biological_process	cellular respiration
O	0046872	molecular_function	metal ion binding
O	0070469	cellular_component	respirasome
O	1902600	biological_process	proton transmembrane transport
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0005750	cellular_component	mitochondrial respiratory chain complex III
P	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
P	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
P	0009060	biological_process	aerobic respiration
P	0016020	cellular_component	membrane
P	0016491	molecular_function	oxidoreductase activity
P	0045333	biological_process	cellular respiration
P	0046872	molecular_function	metal ion binding
P	0051537	molecular_function	2 iron, 2 sulfur cluster binding
P	0070469	cellular_component	respirasome
P	1902600	biological_process	proton transmembrane transport
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005750	cellular_component	mitochondrial respiratory chain complex III
Q	0005758	cellular_component	mitochondrial intermembrane space
Q	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Q	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
Q	0009060	biological_process	aerobic respiration
Q	0034399	cellular_component	nuclear periphery
Q	0045333	biological_process	cellular respiration
Q	0070469	cellular_component	respirasome
Q	1902600	biological_process	proton transmembrane transport
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0005750	cellular_component	mitochondrial respiratory chain complex III
R	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
R	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
R	0009060	biological_process	aerobic respiration
R	0034551	biological_process	mitochondrial respiratory chain complex III assembly
R	0045333	biological_process	cellular respiration
R	0070469	cellular_component	respirasome
R	0099617	cellular_component	matrix side of mitochondrial inner membrane
R	1902600	biological_process	proton transmembrane transport
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0005750	cellular_component	mitochondrial respiratory chain complex III
S	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
S	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
S	0009060	biological_process	aerobic respiration
S	0045333	biological_process	cellular respiration
S	0070469	cellular_component	respirasome
S	1902600	biological_process	proton transmembrane transport
T	0005739	cellular_component	mitochondrion
T	0005743	cellular_component	mitochondrial inner membrane
T	0005750	cellular_component	mitochondrial respiratory chain complex III
T	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
T	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
T	0009060	biological_process	aerobic respiration
T	0034551	biological_process	mitochondrial respiratory chain complex III assembly
T	0045333	biological_process	cellular respiration
T	0070469	cellular_component	respirasome
T	1902600	biological_process	proton transmembrane transport
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0005750	cellular_component	mitochondrial respiratory chain complex III
U	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
U	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
U	0009060	biological_process	aerobic respiration
U	0045333	biological_process	cellular respiration
U	0070469	cellular_component	respirasome
U	1902600	biological_process	proton transmembrane transport
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0005750	cellular_component	mitochondrial respiratory chain complex III
V	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
V	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
V	0009060	biological_process	aerobic respiration
V	0045333	biological_process	cellular respiration
V	0070469	cellular_component	respirasome
V	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue 6PH C 401

Chain	Residue
A	SER450
A	MET455
C	HIS222
C	SER223
C	PHE227
D	LYS291
I	PCF101

---

site_id	AC2
Number of Residues	17
Details	binding site for residue HEM C 402

Chain	Residue
C	GLY47
C	MET50
C	ALA51
C	ARG79
C	HIS82
C	ALA86
C	THR127
C	GLY131
C	TYR132
C	VAL135
C	PHE180
C	HIS183
C	TYR184
C	PRO187
C	TYR274
C	LEU40
C	GLN43

---

site_id	AC3
Number of Residues	16
Details	binding site for residue HEM C 403

Chain	Residue
C	TRP30
C	GLY33
C	HIS96
C	MET97
C	LYS99
C	SER105
C	LEU113
C	TRP114
C	GLY117
C	VAL118
C	ILE120
C	VAL194
C	HIS197
C	LEU201
C	SER207
C	UQ6406

---

site_id	AC4
Number of Residues	10
Details	binding site for residue 8PE C 404

Chain	Residue
C	TRP29
C	TYR102
C	TYR103
C	PHE278
C	THR317
C	PHE327
C	PHE331
C	TYR359
G	GLU82
H	GLN55

---

site_id	AC5
Number of Residues	9
Details	binding site for residue CN5 C 405

Chain	Residue
C	LEU12
C	TYR16
C	MET199
C	HIS202
N	TYR16
N	ILE195
N	MET199
N	6PH402
N	UQ6405

---

site_id	AC6
Number of Residues	8
Details	binding site for residue UQ6 C 406

Chain	Residue
C	TYR16
C	GLN22
C	SER34
C	LEU201
C	SER206
C	MET221
C	ASP229
C	HEM403

---

site_id	AC7
Number of Residues	9
Details	binding site for residue HEM D 401

Chain	Residue
D	VAL100
D	CYS101
D	CYS104
D	HIS105
D	PRO175
D	ARG184
D	PHE218
D	ALA224
D	MET225

---

site_id	AC8
Number of Residues	5
Details	binding site for residue 7PH D 402

Chain	Residue
D	LEU269
D	LYS272
D	THR273
E	SER73
E	GLU76

---

site_id	AC9
Number of Residues	9
Details	binding site for residue FES E 301

Chain	Residue
E	CYS159
E	HIS161
E	LEU162
E	CYS164
E	CYS178
E	CYS180
E	HIS181
E	SER183
E	PRO195

---

site_id	AD1
Number of Residues	11
Details	binding site for residue PCF I 101

Chain	Residue
I	VAL18
I	ILE21
A	ASP428
A	SER453
C	6PH401
E	TYR57
E	GLY64
E	SER68
I	PHE11
I	LYS12
I	PHE17

---

site_id	AD2
Number of Residues	3
Details	binding site for residue 9PE N 401

Chain	Residue
C	ASN7
N	THR112
N	ASN115

---

site_id	AD3
Number of Residues	9
Details	binding site for residue 6PH N 402

Chain	Residue
C	CN5405
L	SER450
L	MET455
N	LEU38
N	HIS222
N	SER223
N	PHE227
O	LYS291
T	PCF101

---

site_id	AD4
Number of Residues	17
Details	binding site for residue HEM N 403

Chain	Residue
N	LEU40
N	GLN43
N	GLY47
N	MET50
N	ALA51
N	ARG79
N	HIS82
N	ALA86
N	THR127
N	GLY131
N	TYR132
N	VAL135
N	PHE180
N	HIS183
N	TYR184
N	PRO187
N	TYR274

---

site_id	AD5
Number of Residues	16
Details	binding site for residue HEM N 404

Chain	Residue
N	TRP30
N	HIS96
N	MET97
N	LYS99
N	SER105
N	LEU113
N	TRP114
N	GLY117
N	ILE120
N	VAL194
N	HIS197
N	LEU198
N	LEU201
N	SER206
N	SER207
N	UQ6405

---

site_id	AD6
Number of Residues	11
Details	binding site for residue UQ6 N 405

Chain	Residue
C	CN5405
N	TYR16
N	ILE17
N	SER34
N	PHE49
N	VAL194
N	LEU198
N	LEU201
N	MET221
N	ASP229
N	HEM404

---

site_id	AD7
Number of Residues	9
Details	binding site for residue 8PE N 406

Chain	Residue
N	TRP29
N	TYR102
N	TYR103
N	THR317
N	PHE327
N	PHE331
N	PHE333
N	TYR359
S	GLN55

---

site_id	AD8
Number of Residues	3
Details	binding site for residue 9PE N 407

Chain	Residue
C	THR112
C	ASN115
N	ASN7

---

site_id	AD9
Number of Residues	10
Details	binding site for residue CN3 N 408

Chain	Residue
N	ASN27
N	TYR28
N	MET32
N	PHE88
O	TYR281
O	ILE285
O	LYS288
O	LYS289
R	HIS85
S	ARG51

---

site_id	AE1
Number of Residues	11
Details	binding site for residue HEM O 401

Chain	Residue
O	VAL100
O	CYS101
O	CYS104
O	HIS105
O	PRO175
O	ARG184
O	TYR190
O	ILE191
O	LEU194
O	PHE218
O	MET225

---

site_id	AE2
Number of Residues	7
Details	binding site for residue 7PH P 301

Chain	Residue
O	LEU269
O	LYS272
O	THR273
P	GLY70
P	SER73
P	GLU76
P	THR77

---

site_id	AE3
Number of Residues	9
Details	binding site for residue FES P 302

Chain	Residue
P	CYS159
P	HIS161
P	LEU162
P	CYS164
P	CYS178
P	CYS180
P	HIS181
P	SER183
P	PRO195

---

site_id	AE4
Number of Residues	8
Details	binding site for residue PCF T 101

Chain	Residue
L	ASP428
L	SER453
N	6PH402
P	TYR57
P	SER68
T	PHE11
T	LYS12
T	VAL18

---

site_id	AE5
Number of Residues	3
Details	binding site for residue CU a 601

Chain	Residue
a	HIS241
a	HIS290
a	HIS291

---

site_id	AE6
Number of Residues	22
Details	binding site for residue HEA a 602

Chain	Residue
a	SER33
a	ILE36
a	ARG37
a	VAL59
a	HIS62
a	ALA63
a	MET66
a	ILE67
a	TRP127
a	TYR371
a	VAL374
a	PHE377
a	HIS378
a	LEU381
a	LEU389
a	PHE390
a	PHE425
a	ARG438
a	ARG439
a	ALA461
a	LEU465
a	PHE468

---

site_id	AE7
Number of Residues	22
Details	binding site for residue HEA a 603

Chain	Residue
a	TRP127
a	TRP237
a	VAL244
a	TYR245
a	ILE248
a	HIS290
a	HIS291
a	ALA313
a	GLY317
a	GLY352
a	GLY355
a	LEU358
a	ALA359
a	ASP364
a	PHE367
a	HIS368
a	VAL373
a	HIS376
a	PHE377
a	VAL380
a	LEU381
a	ARG438

---

site_id	AE8
Number of Residues	6
Details	binding site for residue CUA b 301

Chain	Residue
b	HIS186
b	CYS221
b	GLU223
b	CYS225
b	HIS229
b	MET232

---

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiliipgfgiishvvstyskkpvfgeismvyamasigllgflvws..HH

Chain	Residue	Details
a	TRP237-HIS291

---

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHdfaipslgikvdatpgrlnqvsaliqregvfyga......CselCgtgHanM

Chain	Residue	Details
b	VAL184-MET232

---

site_id	PS00143
Number of Residues	23
Details	INSULINASE Insulinase family, zinc-binding region signature. Ggsryatkd.GvAHLLNRFnFqNT

Chain	Residue	Details
B	GLY37-THR59

---

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. IMWlkptvnevarCweCGsvYKL

Chain	Residue	Details
d	ILE121-LEU143

---

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. IRsKpFfWGDGdKTlFwN

Chain	Residue	Details
k	ILE101-ASN118

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	33
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:30598554

Chain	Residue	Details
k	ALA10-HIS43
N	ILE365-LYS385
d	HIS119
d	CYS134
d	CYS137
a	HIS328-ALA335
a	LEU401-ASN406
a	GLN475-SER534
N	GLY205-SER223
N	ASP309-LYS319

---

site_id	SWS_FT_FI2
Number of Residues	27
Details	TRANSMEM: Helical => ECO:0000269|PubMed:30598554

Chain	Residue	Details
k	ALA44-TYR71
N	GLY75-TYR102
N	VAL111-VAL135
N	ASN173-HIS204
N	TYR224-TYR246
N	LYS288-THR308
N	VAL320-GLY340
N	TYR348-LEU364
V	SER22-THR45
C	VAL111-VAL135
C	ASN173-HIS204
C	TYR224-TYR246
C	LYS288-THR308
C	VAL320-GLY340
C	TYR348-LEU364
N	TYR28-ALA51

---

site_id	SWS_FT_FI3
Number of Residues	57
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:30598554

Chain	Residue	Details
k	PHE72-ASP129
c	SER115-LEU137
c	TYR189-TYR201
c	TRP266-VAL269
a	ALA359-THR370
a	GLY432-GLY449
N	SER247-ASP287
N	ALA341-PRO347

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
c	ASN49-ALA73
E	HIS161
E	CYS178
E	HIS181
P	CYS159
P	HIS161
P	CYS178
P	HIS181

---

site_id	SWS_FT_FI5
Number of Residues	33
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
c	MET81-MET114
b	CYS221
b	CYS225
b	MET232
N	HIS82
N	HIS96
N	HIS183
N	HIS197

---

site_id	SWS_FT_FI6
Number of Residues	23
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
c	PRO138-ALA161
b	HIS229

---

site_id	SWS_FT_FI7
Number of Residues	23
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
c	ASN165-GLU188

---

site_id	SWS_FT_FI8
Number of Residues	28
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
c	GLY202-MET230

---

site_id	SWS_FT_FI9
Number of Residues	16
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
c	TYR249-TYR265

---

site_id	SWS_FT_FI10
Number of Residues	28
Details	TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
a	ALA299-ILE327

---

site_id	SWS_FT_FI11
Number of Residues	22
Details	TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
a	THR336-LEU358

---

site_id	SWS_FT_FI12
Number of Residues	29
Details	TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
a	TYR371-ILE400

---

site_id	SWS_FT_FI13
Number of Residues	24
Details	TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
a	GLU407-LEU431

---

site_id	SWS_FT_FI14
Number of Residues	24
Details	TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
a	TRP450-ASP474

---

site_id	SWS_FT_FI15
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:30598554, ECO:0000269|PubMed:30598556

Chain	Residue	Details
a	GLU39
a	ALA42
a	GLY44
a	HIS241
a	HIS290
a	HIS291
a	HIS368
a	ASP369
a	PRO441

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269|PubMed:30598554, ECO:0000269|PubMed:30598556

Chain	Residue	Details
a	HIS62
a	HIS378

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P00396

Chain	Residue	Details
a	TYR245

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	BINDING: axial binding residue => ECO:0000269|PubMed:30598554

Chain	Residue	Details
a	HIS376

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269|PubMed:30598554

Chain	Residue	Details
a	HIS241
a	TYR245

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 208

Chain	Residue	Details
E	HIS181	covalently attached, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
C	SER206	electrostatic stabiliser, hydrogen bond donor, radical stabiliser
C	LYS228	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
C	ASP229	electrostatic stabiliser, hydrogen bond acceptor, radical stabiliser
C	GLU272	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser

---

site_id	MCSA2
Number of Residues	1
Details	M-CSA 208

Chain	Residue	Details
P	HIS181	covalently attached, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
N	SER206	electrostatic stabiliser, hydrogen bond donor, radical stabiliser
N	LYS228	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
N	ASP229	electrostatic stabiliser, hydrogen bond acceptor, radical stabiliser
N	GLU272	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser

---