6GCS

Cryo-EM structure of respiratory complex I from Yarrowia lipolytica

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
1	0003954	molecular_function	NADH dehydrogenase activity
1	0005739	cellular_component	mitochondrion
1	0005743	cellular_component	mitochondrial inner membrane
1	0005747	cellular_component	mitochondrial respiratory chain complex I
1	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
1	0009060	biological_process	aerobic respiration
1	0016020	cellular_component	membrane
1	0055085	biological_process	transmembrane transport
1	0070469	cellular_component	respirasome
2	0005739	cellular_component	mitochondrion
2	0005743	cellular_component	mitochondrial inner membrane
2	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
2	0016020	cellular_component	membrane
2	0055085	biological_process	transmembrane transport
2	0070469	cellular_component	respirasome
3	0005739	cellular_component	mitochondrion
3	0005747	cellular_component	mitochondrial respiratory chain complex I
3	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
3	0016020	cellular_component	membrane
3	0031966	cellular_component	mitochondrial membrane
3	0055085	biological_process	transmembrane transport
3	0070469	cellular_component	respirasome
4	0003954	molecular_function	NADH dehydrogenase activity
4	0005739	cellular_component	mitochondrion
4	0005747	cellular_component	mitochondrial respiratory chain complex I
4	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
4	0009060	biological_process	aerobic respiration
4	0015990	biological_process	electron transport coupled proton transport
4	0016020	cellular_component	membrane
4	0031966	cellular_component	mitochondrial membrane
4	0042773	biological_process	ATP synthesis coupled electron transport
4	0045271	cellular_component	respiratory chain complex I
4	0048039	molecular_function	ubiquinone binding
4	0070469	cellular_component	respirasome
5	0003954	molecular_function	NADH dehydrogenase activity
5	0005739	cellular_component	mitochondrion
5	0005743	cellular_component	mitochondrial inner membrane
5	0005747	cellular_component	mitochondrial respiratory chain complex I
5	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
5	0015990	biological_process	electron transport coupled proton transport
5	0016020	cellular_component	membrane
5	0042773	biological_process	ATP synthesis coupled electron transport
5	0070469	cellular_component	respirasome
6	0005739	cellular_component	mitochondrion
6	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
6	0016020	cellular_component	membrane
6	0031966	cellular_component	mitochondrial membrane
6	0055085	biological_process	transmembrane transport
6	0070469	cellular_component	respirasome
8	0005739	cellular_component	mitochondrion
8	0005743	cellular_component	mitochondrial inner membrane
8	0005747	cellular_component	mitochondrial respiratory chain complex I
8	0005758	cellular_component	mitochondrial intermembrane space
8	0016020	cellular_component	membrane
9	0005739	cellular_component	mitochondrion
9	0005743	cellular_component	mitochondrial inner membrane
9	0005747	cellular_component	mitochondrial respiratory chain complex I
9	0005758	cellular_component	mitochondrial intermembrane space
9	0016020	cellular_component	membrane
9	0032981	biological_process	mitochondrial respiratory chain complex I assembly
9	0070469	cellular_component	respirasome
A	0003954	molecular_function	NADH dehydrogenase activity
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
A	0042773	biological_process	ATP synthesis coupled electron transport
A	0045333	biological_process	cellular respiration
A	0046872	molecular_function	metal ion binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051537	molecular_function	2 iron, 2 sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
A	0055085	biological_process	transmembrane transport
B	0003954	molecular_function	NADH dehydrogenase activity
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005747	cellular_component	mitochondrial respiratory chain complex I
B	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B	0010181	molecular_function	FMN binding
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0045271	cellular_component	respiratory chain complex I
B	0046872	molecular_function	metal ion binding
B	0051287	molecular_function	NAD binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	0055085	biological_process	transmembrane transport
B	0070469	cellular_component	respirasome
C	0005747	cellular_component	mitochondrial respiratory chain complex I
C	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
C	0016491	molecular_function	oxidoreductase activity
C	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
C	0048038	molecular_function	quinone binding
C	0051287	molecular_function	NAD binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005747	cellular_component	mitochondrial respiratory chain complex I
D	0016020	cellular_component	membrane
D	0070469	cellular_component	respirasome
E	0005739	cellular_component	mitochondrion
E	0044877	molecular_function	protein-containing complex binding
E	1901006	biological_process	ubiquinone-6 biosynthetic process
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005747	cellular_component	mitochondrial respiratory chain complex I
F	0016020	cellular_component	membrane
F	0022904	biological_process	respiratory electron transport chain
G	0005747	cellular_component	mitochondrial respiratory chain complex I
G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
G	0016491	molecular_function	oxidoreductase activity
G	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
G	0055085	biological_process	transmembrane transport
H	0003954	molecular_function	NADH dehydrogenase activity
H	0005747	cellular_component	mitochondrial respiratory chain complex I
H	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
H	0016491	molecular_function	oxidoreductase activity
H	0045271	cellular_component	respiratory chain complex I
H	0046872	molecular_function	metal ion binding
H	0051536	molecular_function	iron-sulfur cluster binding
H	0051537	molecular_function	2 iron, 2 sulfur cluster binding
I	0003954	molecular_function	NADH dehydrogenase activity
I	0005739	cellular_component	mitochondrion
I	0005747	cellular_component	mitochondrial respiratory chain complex I
I	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
I	0016020	cellular_component	membrane
I	0016491	molecular_function	oxidoreductase activity
I	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
I	0032981	biological_process	mitochondrial respiratory chain complex I assembly
I	0046872	molecular_function	metal ion binding
I	0051536	molecular_function	iron-sulfur cluster binding
I	0051539	molecular_function	4 iron, 4 sulfur cluster binding
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005744	cellular_component	TIM23 mitochondrial import inner membrane translocase complex
J	0005747	cellular_component	mitochondrial respiratory chain complex I
J	0008320	molecular_function	protein transmembrane transporter activity
J	0016020	cellular_component	membrane
J	0030150	biological_process	protein import into mitochondrial matrix
J	0032981	biological_process	mitochondrial respiratory chain complex I assembly
K	0005747	cellular_component	mitochondrial respiratory chain complex I
K	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
K	0009060	biological_process	aerobic respiration
K	0015990	biological_process	electron transport coupled proton transport
K	0016491	molecular_function	oxidoreductase activity
K	0032981	biological_process	mitochondrial respiratory chain complex I assembly
K	0046872	molecular_function	metal ion binding
K	0048038	molecular_function	quinone binding
K	0051536	molecular_function	iron-sulfur cluster binding
K	0051539	molecular_function	4 iron, 4 sulfur cluster binding
K	0055085	biological_process	transmembrane transport
L	0005739	cellular_component	mitochondrion
L	0005747	cellular_component	mitochondrial respiratory chain complex I
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0016020	cellular_component	membrane
L	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
L	0031966	cellular_component	mitochondrial membrane
L	0042773	biological_process	ATP synthesis coupled electron transport
L	0055085	biological_process	transmembrane transport
L	0070469	cellular_component	respirasome
M	0005747	cellular_component	mitochondrial respiratory chain complex I
M	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
O	0000035	molecular_function	acyl binding
O	0000036	molecular_function	acyl carrier activity
O	0005739	cellular_component	mitochondrion
O	0005747	cellular_component	mitochondrial respiratory chain complex I
O	0006629	biological_process	lipid metabolic process
O	0006631	biological_process	fatty acid metabolic process
O	0006633	biological_process	fatty acid biosynthetic process
O	0009107	biological_process	lipoate biosynthetic process
O	0016226	biological_process	iron-sulfur cluster assembly
O	0099128	cellular_component	mitochondrial iron-sulfur cluster assembly complex
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0005747	cellular_component	mitochondrial respiratory chain complex I
P	0006979	biological_process	response to oxidative stress
P	0016020	cellular_component	membrane
P	0070469	cellular_component	respirasome
Q	0000035	molecular_function	acyl binding
Q	0000036	molecular_function	acyl carrier activity
Q	0005739	cellular_component	mitochondrion
Q	0005747	cellular_component	mitochondrial respiratory chain complex I
Q	0006629	biological_process	lipid metabolic process
Q	0006631	biological_process	fatty acid metabolic process
Q	0006633	biological_process	fatty acid biosynthetic process
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0005747	cellular_component	mitochondrial respiratory chain complex I
R	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
R	0016020	cellular_component	membrane
R	0070469	cellular_component	respirasome
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0005747	cellular_component	mitochondrial respiratory chain complex I
U	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
U	0016020	cellular_component	membrane
U	0070469	cellular_component	respirasome
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0005747	cellular_component	mitochondrial respiratory chain complex I
W	0016020	cellular_component	membrane
W	0070469	cellular_component	respirasome
X	0005747	cellular_component	mitochondrial respiratory chain complex I
X	0016020	cellular_component	membrane
Y	0005739	cellular_component	mitochondrion
Y	0005743	cellular_component	mitochondrial inner membrane
Y	0005747	cellular_component	mitochondrial respiratory chain complex I
Y	0016020	cellular_component	membrane
Y	0022900	biological_process	electron transport chain
Y	0070469	cellular_component	respirasome
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0005747	cellular_component	mitochondrial respiratory chain complex I
c	0016020	cellular_component	membrane
c	0022900	biological_process	electron transport chain
c	0032981	biological_process	mitochondrial respiratory chain complex I assembly
c	0070469	cellular_component	respirasome
d	0005739	cellular_component	mitochondrion
d	0005743	cellular_component	mitochondrial inner membrane
d	0005747	cellular_component	mitochondrial respiratory chain complex I
d	0016020	cellular_component	membrane
d	0070469	cellular_component	respirasome
f	0005739	cellular_component	mitochondrion
f	0005743	cellular_component	mitochondrial inner membrane
f	0005747	cellular_component	mitochondrial respiratory chain complex I
f	0070469	cellular_component	respirasome
h	0005739	cellular_component	mitochondrion
h	0005743	cellular_component	mitochondrial inner membrane
h	0005747	cellular_component	mitochondrial respiratory chain complex I
h	0006979	biological_process	response to oxidative stress
h	0016020	cellular_component	membrane
h	0032981	biological_process	mitochondrial respiratory chain complex I assembly
h	0070469	cellular_component	respirasome
j	0016020	cellular_component	membrane
j	0016491	molecular_function	oxidoreductase activity

PDBデータベースに由来する情報

site_id	AC1
残基数	11
詳細	binding site for residue SF4 A 801

鎖名	残基
A	HIS129
A	VAL235
A	GLY236
A	ASP132
A	CYS133
A	CYS136
A	GLN138
A	CYS142
A	LEU144
A	GLN145
A	ARG182

---

site_id	AC2
残基数	7
詳細	binding site for residue SF4 A 802

鎖名	残基
A	CYS183
A	CYS186
A	THR187
A	CYS189
A	CYS233
A	ALA237
A	LEU238

---

site_id	AC3
残基数	8
詳細	binding site for residue FES A 803

鎖名	残基
A	CYS69
A	TYR70
A	ALA77
A	CYS80
A	ARG81
A	MET82
A	CYS83
A	CYS97

---

site_id	AC4
残基数	8
詳細	binding site for residue SF4 B 501

鎖名	残基
B	VAL207
B	CYS381
B	GLY382
B	CYS384
B	CYS387
B	CYS427
B	LEU429
B	GLY430

---

site_id	AC5
残基数	17
詳細	binding site for residue FMN B 502

鎖名	残基
B	GLY86
B	ARG87
B	GLY88
B	LYS97
B	ASN118
B	ASP120
B	GLU121
B	GLY122
B	TYR206
B	GLY209
B	GLU210
B	VAL244
B	THR245
B	ASN246
B	THR249
B	ALA428
B	LEU429

---

site_id	AC6
残基数	19
詳細	binding site for residue NDP E 401

鎖名	残基
E	GLY60
E	ASN62
E	GLY63
E	PHE64
E	LEU65
E	ARG85
E	LEU109
E	ILE129
E	GLY130
E	ARG131
E	GLU132
E	PHE138
E	PHE169
E	LYS183
E	PRO202
E	ALA203
E	MET205
E	LYS211
K	ARG209

---

site_id	AC7
残基数	8
詳細	binding site for residue FES H 301

鎖名	残基
H	CYS127
H	PRO131
H	CYS132
H	CYS168
H	LEU169
H	GLY170
H	ALA171
H	CYS172

---

site_id	AC8
残基数	11
詳細	binding site for residue SF4 I 301

鎖名	残基
I	HIS118
I	CYS140
I	PRO141
I	ILE145
I	CYS169
I	ILE170
I	CYS172
I	GLY173
I	TYR174
I	CYS175
I	GLU186

---

site_id	AC9
残基数	9
詳細	binding site for residue SF4 I 302

鎖名	残基
I	CYS130
I	ILE131
I	ALA132
I	CYS133
I	LYS134
I	CYS136
I	ILE147
I	TYR162
I	CYS179

---

site_id	AD1
残基数	10
詳細	binding site for residue SF4 K 301

鎖名	残基
K	ALA84
K	CYS85
K	CYS86
K	GLY121
K	THR122
K	SER149
K	CYS150
K	CYS180
K	PRO181
C	ARG141

---

site_id	AD2
残基数	4
詳細	binding site for residue ZN M 201

鎖名	残基
M	CYS97
M	HIS110
M	CYS125
M	CYS128

---

site_id	AD3
残基数	11
詳細	binding site for residue ZMP O 201

鎖名	残基
O	SER66
O	LEU67
P	GLN22
P	PHE32
P	PHE60
P	HIS63
P	ARG64
P	GLN72
P	LEU75
P	GLY79
P	TYR99

---

site_id	AD4
残基数	13
詳細	binding site for residue CDL g 201

鎖名	残基
2	SER8
2	THR11
2	PHE12
2	MET15
X	PRO20
X	PHE74
X	ARG76
X	VAL77
X	MET80
g	TRP9
g	TYR15
g	PHE30
g	3PE202

---

site_id	AD5
残基数	9
詳細	binding site for residue 3PE g 202

鎖名	残基
3	ILE99
3	VAL103
3	ASN107
g	TYR15
g	SER19
g	ARG23
g	LEU26
g	PHE30
g	CDL201

---

site_id	AD6
残基数	15
詳細	binding site for residue 3PE 1 401

鎖名	残基
1	PRO184
1	LEU185
1	ILE188
1	PHE190
1	ILE191
1	PHE303
1	ASN310
1	PHE311
1	ILE323
C	LEU273
I	TYR77
I	PHE78
I	LEU80
I	MET83
W	CYS41

---

site_id	AD7
残基数	4
詳細	binding site for residue 3PE 4 501

鎖名	残基
2	LEU362
4	ASN112
4	LEU113
4	THR116

---

UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS00535
残基数	12
詳細	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

鎖名	残基	詳細
C	LEU119-LYS130

---

site_id	PS00198
残基数	12
詳細	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaICP

鎖名	残基	詳細
I	CYS130-PRO141
I	CYS169-PRO180

---

site_id	PS00641
残基数	18
詳細	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PryCYhdklaiaGnCRmC

鎖名	残基	詳細
A	PRO66-CYS83

---

site_id	PS00642
残基数	13
詳細	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPvCDqGGeCdLQ

鎖名	残基	詳細
A	CYS133-GLN145

---

site_id	PS00643
残基数	11
詳細	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIhCtRCVrF

鎖名	残基	詳細
A	ARG182-PHE192

---

site_id	PS01150
残基数	17
詳細	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDVYvPgCPP

鎖名	残基	詳細
K	GLY166-PRO182

---

site_id	PS01099
残基数	19
詳細	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DnlFTlseveCLGaCvnAP

鎖名	残基	詳細
H	ASP158-PRO176

---

site_id	PS00644
残基数	16
詳細	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GMGAYVCGEETSLIES

鎖名	残基	詳細
B	GLY202-SER217

---

site_id	PS00645
残基数	12
詳細	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

鎖名	残基	詳細
B	GLU379-GLY390

---

site_id	PS00133
残基数	11
詳細	CARBOXYPEPT_ZN_2 Zinc carboxypeptidases, zinc-binding region 2 signature. HSIAGLFiFPW

鎖名	残基	詳細
X	HIS145-TRP155

---

site_id	PS00667
残基数	16
詳細	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQaFaDAVKLLlKE

鎖名	残基	詳細
1	GLY46-GLU61

---

site_id	PS00668
残基数	14
詳細	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLTESEseLVa.G

鎖名	残基	詳細
1	PRO201-GLY214

---

site_id	PS00542
残基数	22
詳細	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREayDMYgvffegHpdlRrIM

鎖名	残基	詳細
G	GLU179-MET200

---

site_id	PS00012
残基数	16
詳細	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDVVEVVMAI

鎖名	残基	詳細
Q	ASP84-ILE99
O	ASP61-ILE76

---

SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	100
詳細	TRANSMEM: Helical => ECO:0000255

鎖名	残基	詳細
6	LEU4-ILE24
5	ILE304-LEU322
5	LEU332-LEU354
5	LEU370-LEU390
5	VAL413-LEU433
5	ILE456-LEU476
5	ILE516-PHE536
5	LEU629-ILE649
6	ILE33-GLY53
6	ILE54-ILE74
6	LEU94-ASN114
6	ALA159-ILE179
5	PHE180-ILE200
5	ALA204-MET224
5	THR244-LEU264
5	VAL276-ILE296

---