6GCI
Structure of the bongkrekic acid-inhibited mitochondrial ADP/ATP carrier
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005471 | molecular_function | ATP:ADP antiporter activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0140021 | biological_process | mitochondrial ADP transmembrane transport |
| A | 1990544 | biological_process | mitochondrial ATP transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue BKC A 401 |
| Chain | Residue |
| A | LYS30 |
| A | ARG197 |
| A | TYR200 |
| A | ARG287 |
| A | GLY291 |
| A | ARG88 |
| A | TYR89 |
| A | THR92 |
| A | GLN93 |
| A | ASN96 |
| A | LEU135 |
| A | ILE193 |
| A | TYR196 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue CDL A 802 |
| Chain | Residue |
| A | LEU136 |
| A | TYR183 |
| A | ARG184 |
| A | GLY185 |
| A | PHE186 |
| A | GLY187 |
| A | PRO188 |
| A | TRP228 |
| A | SER260 |
| A | SER261 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CDL A 800 |
| Chain | Residue |
| A | TRP79 |
| A | GLY81 |
| A | ASN82 |
| A | THR83 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue CDL A 801 |
| Chain | Residue |
| A | PHE278 |
| A | LYS279 |
| A | GLY280 |
| A | ALA281 |
| A | GLY282 |
| A | ALA283 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CDL A 803 |
| Chain | Residue |
| A | GLY165 |
| A | LEU166 |
| A | ILE167 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue CDL A 804 |
| Chain | Residue |
| A | GLY61 |
| A | ILE62 |
| A | ILE63 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue P6G B 301 |
| Chain | Residue |
| B | ARG45 |
| B | ARG45 |
| B | ASN93 |
| B | ASN93 |
| B | TYR109 |
| B | TYR109 |
| B | TRP114 |
| B | TRP114 |
| B | GLN116 |
| B | GLN116 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"30611538","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6GCI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | Topological domain: {"description":"Mitochondrial matrix","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"30611538","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6GCI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 29 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"30611538","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6GCI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 28 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"30611538","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6GCI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"30611538","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6GCI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"30611538","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6GCI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 185 |
| Details | Repeat: {"description":"Solcar","evidences":[{"source":"PROSITE-ProRule","id":"PRU00282","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 5 |
| Details | Motif: {"description":"Nucleotide carrier signature motif","evidences":[{"source":"UniProtKB","id":"P02722","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30611538","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6GCI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P18238","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P02722","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
