6GCI

Structure of the bongkrekic acid-inhibited mitochondrial ADP/ATP carrier

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005471	molecular_function	ATP:ADP antiporter activity
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0015297	molecular_function	antiporter activity
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
A	0140021	biological_process	mitochondrial ADP transmembrane transport
A	1990544	biological_process	mitochondrial ATP transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue BKC A 401

Chain	Residue
A	LYS30
A	ARG197
A	TYR200
A	ARG287
A	GLY291
A	ARG88
A	TYR89
A	THR92
A	GLN93
A	ASN96
A	LEU135
A	ILE193
A	TYR196

---

site_id	AC2
Number of Residues	10
Details	binding site for residue CDL A 802

Chain	Residue
A	LEU136
A	TYR183
A	ARG184
A	GLY185
A	PHE186
A	GLY187
A	PRO188
A	TRP228
A	SER260
A	SER261

---

site_id	AC3
Number of Residues	4
Details	binding site for residue CDL A 800

Chain	Residue
A	TRP79
A	GLY81
A	ASN82
A	THR83

---

site_id	AC4
Number of Residues	6
Details	binding site for residue CDL A 801

Chain	Residue
A	PHE278
A	LYS279
A	GLY280
A	ALA281
A	GLY282
A	ALA283

---

site_id	AC5
Number of Residues	3
Details	binding site for residue CDL A 803

Chain	Residue
A	GLY165
A	LEU166
A	ILE167

---

site_id	AC6
Number of Residues	3
Details	binding site for residue CDL A 804

Chain	Residue
A	GLY61
A	ILE62
A	ILE63

---

site_id	AC7
Number of Residues	10
Details	binding site for residue P6G B 301

Chain	Residue
B	ARG45
B	ARG45
B	ASN93
B	ASN93
B	TYR109
B	TYR109
B	TRP114
B	TRP114
B	GLN116
B	GLN116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	34
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000305

Chain	Residue	Details
A	MET1-PRO13
A	ALA105-GLY115
A	GLY214-LEU216
A	LEU305-GLY315

---

site_id	SWS_FT_FI2
Number of Residues	23
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:30611538, ECO:0007744|PDB:6GCI

Chain	Residue	Details
A	PRO14-GLU37

---

site_id	SWS_FT_FI3
Number of Residues	120
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000305

Chain	Residue	Details
A	ARG38-ARG80
A	THR146-ARG184
A	THR243-ALA283

---

site_id	SWS_FT_FI4
Number of Residues	23
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:30611538, ECO:0007744|PDB:6GCI

Chain	Residue	Details
A	GLY81-LYS104

---

site_id	SWS_FT_FI5
Number of Residues	29
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:30611538, ECO:0007744|PDB:6GCI

Chain	Residue	Details
A	TYR116-ARG145

---

site_id	SWS_FT_FI6
Number of Residues	28
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:30611538, ECO:0007744|PDB:6GCI

Chain	Residue	Details
A	GLY185-VAL213

---

site_id	SWS_FT_FI7
Number of Residues	25
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:30611538, ECO:0007744|PDB:6GCI

Chain	Residue	Details
A	ALA217-ASP242

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:30611538, ECO:0007744|PDB:6GCI

Chain	Residue	Details
A	ASN284-LEU304

---

site_id	SWS_FT_FI9
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:30611538, ECO:0007744|PDB:6GCI

Chain	Residue	Details
A	LYS30
A	ILE62
A	GLY81
A	ASN96
A	LEU166
A	ARG184
A	TYR196
A	SER260
A	GLY280

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P18238

Chain	Residue	Details
A	ARG88
A	ARG245

---