6GCI
Structure of the bongkrekic acid-inhibited mitochondrial ADP/ATP carrier
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005471 | molecular_function | ATP:ADP antiporter activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071702 | biological_process | organic substance transport |
| A | 0071705 | biological_process | nitrogen compound transport |
| A | 0140021 | biological_process | mitochondrial ADP transmembrane transport |
| A | 1901029 | biological_process | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| A | 1990544 | biological_process | mitochondrial ATP transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue BKC A 401 |
| Chain | Residue |
| A | LYS30 |
| A | ARG197 |
| A | TYR200 |
| A | ARG287 |
| A | GLY291 |
| A | ARG88 |
| A | TYR89 |
| A | THR92 |
| A | GLN93 |
| A | ASN96 |
| A | LEU135 |
| A | ILE193 |
| A | TYR196 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue CDL A 802 |
| Chain | Residue |
| A | LEU136 |
| A | TYR183 |
| A | ARG184 |
| A | GLY185 |
| A | PHE186 |
| A | GLY187 |
| A | PRO188 |
| A | TRP228 |
| A | SER260 |
| A | SER261 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CDL A 800 |
| Chain | Residue |
| A | TRP79 |
| A | GLY81 |
| A | ASN82 |
| A | THR83 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue CDL A 801 |
| Chain | Residue |
| A | PHE278 |
| A | LYS279 |
| A | GLY280 |
| A | ALA281 |
| A | GLY282 |
| A | ALA283 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CDL A 803 |
| Chain | Residue |
| A | GLY165 |
| A | LEU166 |
| A | ILE167 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue CDL A 804 |
| Chain | Residue |
| A | GLY61 |
| A | ILE62 |
| A | ILE63 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue P6G B 301 |
| Chain | Residue |
| B | ARG45 |
| B | ARG45 |
| B | ASN93 |
| B | ASN93 |
| B | TYR109 |
| B | TYR109 |
| B | TRP114 |
| B | TRP114 |
| B | GLN116 |
| B | GLN116 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 34 |
| Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000305 |
| Chain | Residue | Details |
| A | MET1-PRO13 | |
| A | ALA105-GLY115 | |
| A | GLY214-LEU216 | |
| A | LEU305-GLY315 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:30611538, ECO:0007744|PDB:6GCI |
| Chain | Residue | Details |
| A | PRO14-GLU37 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 120 |
| Details | TOPO_DOM: Mitochondrial matrix => ECO:0000305 |
| Chain | Residue | Details |
| A | ARG38-ARG80 | |
| A | THR146-ARG184 | |
| A | THR243-ALA283 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:30611538, ECO:0007744|PDB:6GCI |
| Chain | Residue | Details |
| A | GLY81-LYS104 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:30611538, ECO:0007744|PDB:6GCI |
| Chain | Residue | Details |
| A | TYR116-ARG145 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:30611538, ECO:0007744|PDB:6GCI |
| Chain | Residue | Details |
| A | GLY185-VAL213 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:30611538, ECO:0007744|PDB:6GCI |
| Chain | Residue | Details |
| A | ALA217-ASP242 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:30611538, ECO:0007744|PDB:6GCI |
| Chain | Residue | Details |
| A | ASN284-LEU304 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30611538, ECO:0007744|PDB:6GCI |
| Chain | Residue | Details |
| A | GLY81 | |
| A | ASN96 | |
| A | LEU166 | |
| A | ARG184 | |
| A | TYR196 | |
| A | SER260 | |
| A | GLY280 | |
| A | LYS30 | |
| A | ILE62 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P18238 |
| Chain | Residue | Details |
| A | ARG88 | |
| A | ARG245 |
