6G9E

Crystal structure of immunomodulatory active chitinase from Trichuris suis - TsES1 - 6 molecules in ASU

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0004568	molecular_function	chitinase activity
A	0005576	cellular_component	extracellular region
A	0005975	biological_process	carbohydrate metabolic process
A	0006032	biological_process	chitin catabolic process
A	0008061	molecular_function	chitin binding
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
B	0004568	molecular_function	chitinase activity
B	0005576	cellular_component	extracellular region
B	0005975	biological_process	carbohydrate metabolic process
B	0006032	biological_process	chitin catabolic process
B	0008061	molecular_function	chitin binding
B	0016787	molecular_function	hydrolase activity
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
C	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
C	0004568	molecular_function	chitinase activity
C	0005576	cellular_component	extracellular region
C	0005975	biological_process	carbohydrate metabolic process
C	0006032	biological_process	chitin catabolic process
C	0008061	molecular_function	chitin binding
C	0016787	molecular_function	hydrolase activity
C	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
D	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
D	0004568	molecular_function	chitinase activity
D	0005576	cellular_component	extracellular region
D	0005975	biological_process	carbohydrate metabolic process
D	0006032	biological_process	chitin catabolic process
D	0008061	molecular_function	chitin binding
D	0016787	molecular_function	hydrolase activity
D	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
E	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
E	0004568	molecular_function	chitinase activity
E	0005576	cellular_component	extracellular region
E	0005975	biological_process	carbohydrate metabolic process
E	0006032	biological_process	chitin catabolic process
E	0008061	molecular_function	chitin binding
E	0016787	molecular_function	hydrolase activity
E	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
F	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
F	0004568	molecular_function	chitinase activity
F	0005576	cellular_component	extracellular region
F	0005975	biological_process	carbohydrate metabolic process
F	0006032	biological_process	chitin catabolic process
F	0008061	molecular_function	chitin binding
F	0016787	molecular_function	hydrolase activity
F	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue EDO A 501

Chain	Residue
A	TRP42
A	ARG46
A	TYR302
A	LEU303
B	SER127

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site_id	AC2
Number of Residues	7
Details	binding site for residue EDO B 501

Chain	Residue
B	TYR220
B	TRP368
B	HOH618
B	PHE69
B	GLY111
B	GLU153
B	MET218

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site_id	AC3
Number of Residues	6
Details	binding site for residue EDO C 501

Chain	Residue
C	ALA209
C	LYS210
C	VAL211
C	LEU212
C	ASP213
C	GLN267

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site_id	AC4
Number of Residues	4
Details	binding site for residue EDO C 502

Chain	Residue
C	GLU161
C	LEU164
C	LEU165
C	GLN168

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site_id	AC5
Number of Residues	4
Details	binding site for residue EDO D 501

Chain	Residue
D	GLU153
D	MET218
D	TYR220
D	TRP368

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Functional Information from PROSITE/UniProt

site_id	PS01095
Number of Residues	9
Details	GH18_1 Glycosyl hydrolases family 18 (GH18) active site signature. FDGFDLDwE

Chain	Residue	Details
A	PHE145-GLU153

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