6G8I

14-3-3sigma in complex with a R124beta3R mutated YAP pS127 phosphopeptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0001836	biological_process	release of cytochrome c from mitochondria
A	0003334	biological_process	keratinocyte development
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006469	biological_process	negative regulation of protein kinase activity
A	0006611	biological_process	protein export from nucleus
A	0007165	biological_process	signal transduction
A	0008426	molecular_function	protein kinase C inhibitor activity
A	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
A	0010482	biological_process	regulation of epidermal cell division
A	0010737	biological_process	protein kinase A signaling
A	0010839	biological_process	negative regulation of keratinocyte proliferation
A	0019901	molecular_function	protein kinase binding
A	0030216	biological_process	keratinocyte differentiation
A	0030307	biological_process	positive regulation of cell growth
A	0031424	biological_process	keratinization
A	0042802	molecular_function	identical protein binding
A	0043154	biological_process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A	0043588	biological_process	skin development
A	0043616	biological_process	keratinocyte proliferation
A	0045296	molecular_function	cadherin binding
A	0045606	biological_process	positive regulation of epidermal cell differentiation
A	0045824	biological_process	negative regulation of innate immune response
A	0046827	biological_process	positive regulation of protein export from nucleus
A	0050815	molecular_function	phosphoserine residue binding
A	0051219	molecular_function	phosphoprotein binding
A	0051726	biological_process	regulation of cell cycle
A	0061436	biological_process	establishment of skin barrier
A	0070062	cellular_component	extracellular exosome
A	0072089	biological_process	stem cell proliferation
A	0140311	molecular_function	protein sequestering activity
A	2000647	biological_process	negative regulation of stem cell proliferation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CL A 301

Chain	Residue
A	LYS9
A	LYS87
A	HOH709
A	HOH735

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site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 302

Chain	Residue
A	HOH663
A	GLU75
A	GLU161
A	HOH456
A	HOH523
A	HOH619

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site_id	AC3
Number of Residues	6
Details	binding site for residue NA A 303

Chain	Residue
A	GLN8
A	LYS77
A	GLU80
A	HOH491
A	HOH598
A	HOH657

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site_id	AC4
Number of Residues	4
Details	binding site for residue NA A 304

Chain	Residue
A	GLY-1
A	HOH491
A	HOH528
A	HOH559

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Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
A	ARG41-VAL51

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine; by LATS1 and LATS2 => ECO:0000269|PubMed:17974916, ECO:0000269|PubMed:18158288, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:28169360, ECO:0007744|PubMed:18669648

Chain	Residue	Details
P	SEP127
A	ARG129

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
P	SER128

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:24275569

Chain	Residue	Details
P	SER131

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