Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6G7X

Crystal structure of H. pylori purine nucleoside phosphorylase soaked in PO4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004731	molecular_function	purine-nucleoside phosphorylase activity
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006152	biological_process	purine nucleoside catabolic process
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
B	0003824	molecular_function	catalytic activity
B	0004731	molecular_function	purine-nucleoside phosphorylase activity
B	0005829	cellular_component	cytosol
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006152	biological_process	purine nucleoside catabolic process
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
C	0003824	molecular_function	catalytic activity
C	0004731	molecular_function	purine-nucleoside phosphorylase activity
C	0005829	cellular_component	cytosol
C	0006139	biological_process	nucleobase-containing compound metabolic process
C	0006152	biological_process	purine nucleoside catabolic process
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
D	0003824	molecular_function	catalytic activity
D	0004731	molecular_function	purine-nucleoside phosphorylase activity
D	0005829	cellular_component	cytosol
D	0006139	biological_process	nucleobase-containing compound metabolic process
D	0006152	biological_process	purine nucleoside catabolic process
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
E	0003824	molecular_function	catalytic activity
E	0004731	molecular_function	purine-nucleoside phosphorylase activity
E	0005829	cellular_component	cytosol
E	0006139	biological_process	nucleobase-containing compound metabolic process
E	0006152	biological_process	purine nucleoside catabolic process
E	0009116	biological_process	nucleoside metabolic process
E	0009164	biological_process	nucleoside catabolic process
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
F	0003824	molecular_function	catalytic activity
F	0004731	molecular_function	purine-nucleoside phosphorylase activity
F	0005829	cellular_component	cytosol
F	0006139	biological_process	nucleobase-containing compound metabolic process
F	0006152	biological_process	purine nucleoside catabolic process
F	0009116	biological_process	nucleoside metabolic process
F	0009164	biological_process	nucleoside catabolic process
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue IMD A 301

Chain	Residue
A	HIS4
A	ARG43
D	MET64
D	PHE159
D	MET180
D	HOH424

site_id	AC2
Number of Residues	1
Details	binding site for residue IMD A 302

Chain	Residue
A	HOH522

site_id	AC3
Number of Residues	2
Details	binding site for residue IMD A 303

Chain	Residue
A	GLU38
A	ASN41

site_id	AC4
Number of Residues	9
Details	binding site for residue PO4 A 304

Chain	Residue
A	ASP21
A	ARG24
A	GLY89
A	THR90
A	HOH408
A	HOH415
A	HOH429
D	ARG43
D	IMD302

site_id	AC5
Number of Residues	5
Details	binding site for residue IMD B 301

Chain	Residue
B	HIS4
B	ARG43
E	MET64
E	PHE159
E	PO4305

site_id	AC6
Number of Residues	2
Details	binding site for residue IMD B 302

Chain	Residue
B	PHE159
B	HOH520

site_id	AC7
Number of Residues	4
Details	binding site for residue IMD B 303

Chain	Residue
B	ASN6
B	GLU38
B	THR40
B	ASN41

site_id	AC8
Number of Residues	10
Details	binding site for residue IMD B 304

Chain	Residue
A	ARG117
A	VAL118
A	ASN122
A	HOH414
A	HOH528
B	LEU121
B	ASN122
B	HIS123
B	HOH430
D	GLU163

site_id	AC9
Number of Residues	7
Details	binding site for residue IMD B 305

Chain	Residue
B	ARG117
B	ASN122
B	HOH447
B	HOH513
C	HIS123
C	HOH518
E	HOH411

site_id	AD1
Number of Residues	9
Details	binding site for residue PO4 B 306

Chain	Residue
B	CYS19
B	ARG24
B	GLY89
B	THR90
B	HOH402
B	HOH407
B	HOH537
E	ARG43
E	IMD302

site_id	AD2
Number of Residues	7
Details	binding site for residue IMD C 301

Chain	Residue
C	HIS4
C	ARG43
F	MET64
F	PHE159
F	MET180
F	PO4305
F	HOH481

site_id	AD3
Number of Residues	3
Details	binding site for residue IMD C 302

Chain	Residue
C	PHE159
C	MET180
C	HOH499

site_id	AD4
Number of Residues	4
Details	binding site for residue IMD C 303

Chain	Residue
C	GLU38
C	ILE39
C	ASN41
C	HOH542

site_id	AD5
Number of Residues	9
Details	binding site for residue IMD C 304

Chain	Residue
A	ASN122
A	HIS123
A	HOH529
C	LYS114
C	VAL118
C	ASN122
C	HOH412
C	HOH545
F	HOH428

site_id	AD6
Number of Residues	9
Details	binding site for residue PO4 C 305

Chain	Residue
C	CYS19
C	GLY20
C	ARG24
C	GLY89
C	THR90
C	HOH402
C	HOH406
F	ARG43
F	IMD302

site_id	AD7
Number of Residues	3
Details	binding site for residue IMD D 301

Chain	Residue
D	ILE178
D	HOH406
D	HOH410

site_id	AD8
Number of Residues	7
Details	binding site for residue IMD D 302

Chain	Residue
A	MET64
A	PHE159
A	MET180
A	PO4304
A	HOH469
D	HIS4
D	ARG43

site_id	AD9
Number of Residues	2
Details	binding site for residue IMD D 303

Chain	Residue
D	ASN41
D	HOH435

site_id	AE1
Number of Residues	9
Details	binding site for residue PO4 D 304

Chain	Residue
A	ARG43
D	CYS19
D	ASP21
D	ARG24
D	GLY89
D	THR90
D	HOH414
D	HOH419
D	HOH436

site_id	AE2
Number of Residues	2
Details	binding site for residue IMD E 301

Chain	Residue
E	HOH490
E	HOH510

site_id	AE3
Number of Residues	6
Details	binding site for residue IMD E 302

Chain	Residue
B	MET64
B	PHE159
B	PO4306
B	HOH416
E	HIS4
E	ARG43

site_id	AE4
Number of Residues	5
Details	binding site for residue IMD E 303

Chain	Residue
E	ASN6
E	GLU38
E	ILE39
E	ASN41
E	HOH421

site_id	AE5
Number of Residues	7
Details	binding site for residue IMD E 304

Chain	Residue
D	HIS123
D	HOH439
D	HOH519
E	ARG117
E	VAL118
E	ASN122
E	HOH415

site_id	AE6
Number of Residues	9
Details	binding site for residue PO4 E 305

Chain	Residue
B	ARG43
B	IMD301
E	CYS19
E	ARG24
E	GLY89
E	THR90
E	HOH403
E	HOH404
E	HOH409

site_id	AE7
Number of Residues	1
Details	binding site for residue IMD F 301

Chain	Residue
F	HOH407

site_id	AE8
Number of Residues	6
Details	binding site for residue IMD F 302

Chain	Residue
C	MET64
C	PHE159
C	PO4305
C	HOH415
F	HIS4
F	ARG43

site_id	AE9
Number of Residues	4
Details	binding site for residue IMD F 303

Chain	Residue
F	ASN6
F	GLU38
F	ILE39
F	ASN41

site_id	AF1
Number of Residues	7
Details	binding site for residue IMD F 304

Chain	Residue
C	HOH417
E	LEU121
E	HIS123
F	LYS114
F	ARG117
F	ASN122
F	HOH501

site_id	AF2
Number of Residues	7
Details	binding site for residue PO4 F 305

Chain	Residue
C	ARG43
C	IMD301
F	CYS19
F	GLY89
F	THR90
F	HOH402
F	HOH403

Functional Information from PROSITE/UniProt

site_id	PS01232
Number of Residues	16
Details	PNP_UDP_1 Purine and other phosphorylases family 1 signature. GhGMGiAScTIyvtEL

Chain	Residue	Details
A	GLY61-LEU76

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton donor => ECO:0000255\|HAMAP-Rule:MF_01627

Chain	Residue	Details
A	ASP204
B	ASP204
C	ASP204
D	ASP204
E	ASP204
F	ASP204

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P50389

Chain	Residue	Details
A	HIS4
E	ARG43
F	HIS4
F	ARG43
A	ARG43
B	HIS4
B	ARG43
C	HIS4
C	ARG43
D	HIS4
D	ARG43
E	HIS4

site_id	SWS_FT_FI3
Number of Residues	30
Details	BINDING: in other chain => ECO:0000250\|UniProtKB:P50389

Chain	Residue	Details
A	GLY20
B	SER203
C	GLY20
C	ARG24
C	ARG87
C	GLU179
C	SER203
D	GLY20
D	ARG24
D	ARG87
D	GLU179
A	ARG24
D	SER203
E	GLY20
E	ARG24
E	ARG87
E	GLU179
E	SER203
F	GLY20
F	ARG24
F	ARG87
F	GLU179
A	ARG87
F	SER203
A	GLU179
A	SER203
B	GLY20
B	ARG24
B	ARG87
B	GLU179

site_id	SWS_FT_FI4
Number of Residues	6
Details	SITE: Important for catalytic activity => ECO:0000255\|HAMAP-Rule:MF_01627

Chain	Residue	Details
A	ARG217
B	ARG217
C	ARG217
D	ARG217
E	ARG217
F	ARG217

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)