6G7D

Structure of MeT1 from Mycobacterium hassiacum in complex with SAM and glycerol.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008168	molecular_function	methyltransferase activity
A	0032259	biological_process	methylation
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue SAH A 301

Chain	Residue
A	GLY19
A	GLY75
A	SER76
A	GLY122
A	LYS123
A	SER124
A	ASP141
A	GLY142
A	GLY143
A	ARG151
A	CL306
A	PHE20
A	HOH456
A	HOH460
A	HOH486
A	GLU44
A	GLY46
A	THR47
A	TYR48
A	SER52
A	ASP71
A	HIS72

---

site_id	AC2
Number of Residues	10
Details	binding site for residue GOL A 302

Chain	Residue
A	ILE4
A	ARG5
A	ASP6
A	THR7
A	GLN62
A	LYS123
A	HOH445
A	HOH475
A	HOH567
A	HOH600

---

site_id	AC3
Number of Residues	11
Details	binding site for residue GOL A 303

Chain	Residue
A	GLU78
A	HIS79
A	ASP141
A	HIS144
A	ASP170
A	MG304
A	HOH403
A	HOH415
A	HOH420
A	HOH433
A	HOH560

---

site_id	AC4
Number of Residues	6
Details	binding site for residue MG A 304

Chain	Residue
A	ASP141
A	HIS169
A	ASP170
A	GOL303
A	HOH415
A	HOH420

---

site_id	AC5
Number of Residues	5
Details	binding site for residue MG A 305

Chain	Residue
A	ASP112
A	HOH435
A	HOH508
A	HOH555
A	HOH568

---

site_id	AC6
Number of Residues	5
Details	binding site for residue CL A 306

Chain	Residue
A	SER124
A	ALA125
A	ARG151
A	SAH301
A	HOH475

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000305|PubMed:30606802

Chain	Residue	Details
A	HIS144

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING: BINDING => ECO:0000305|PubMed:30606802

Chain	Residue	Details
A	PHE20
A	GLY46
A	SER52
A	ASP71
A	GLY75
A	SER124
A	ARG151

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:30606802

Chain	Residue	Details
A	ASP141
A	HIS169
A	ASP170

---