6G5Z
Choline sulfatase from Ensifer (Sinorhizobium) meliloti
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004423 | molecular_function | iduronate-2-sulfatase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042425 | biological_process | choline biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047753 | molecular_function | choline-sulfatase activity |
| B | 0004423 | molecular_function | iduronate-2-sulfatase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0042425 | biological_process | choline biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047753 | molecular_function | choline-sulfatase activity |
| C | 0004423 | molecular_function | iduronate-2-sulfatase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0042425 | biological_process | choline biosynthetic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0047753 | molecular_function | choline-sulfatase activity |
| D | 0004423 | molecular_function | iduronate-2-sulfatase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0042425 | biological_process | choline biosynthetic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0047753 | molecular_function | choline-sulfatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 1001 |
| Chain | Residue |
| A | ASP14 |
| A | DDZ54 |
| A | ASP296 |
| A | HIS297 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1002 |
| Chain | Residue |
| A | ARG445 |
| A | TRP449 |
| A | ASP450 |
| A | MET451 |
| A | GLU452 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 1003 |
| Chain | Residue |
| A | ARG71 |
| A | HOH1102 |
| C | ARG71 |
| C | HOH1168 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 1004 |
| Chain | Residue |
| A | HIS333 |
| A | LEU334 |
| A | THR335 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 1005 |
| Chain | Residue |
| A | PRO222 |
| A | GLU223 |
| A | ARG259 |
| A | HOH1110 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 1006 |
| Chain | Residue |
| A | LEU53 |
| A | DDZ54 |
| A | ASN75 |
| A | HIS104 |
| A | TYR123 |
| A | HIS201 |
| A | LYS309 |
| A | HOH1101 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 1001 |
| Chain | Residue |
| B | ASP14 |
| B | DDZ54 |
| B | ASP296 |
| B | HIS297 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 1002 |
| Chain | Residue |
| B | HIS333 |
| B | LEU334 |
| B | THR335 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 1003 |
| Chain | Residue |
| B | ARG445 |
| B | TRP449 |
| B | ASP450 |
| B | MET451 |
| B | GLU452 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 1004 |
| Chain | Residue |
| B | LEU29 |
| B | HIS30 |
| B | ALA31 |
| B | PRO32 |
| B | LYS35 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 1005 |
| Chain | Residue |
| B | GLN435 |
| B | GLN435 |
| B | LEU438 |
| B | LEU438 |
| B | ARG442 |
| B | ARG442 |
| B | HOH1211 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 1006 |
| Chain | Residue |
| B | PRO228 |
| B | LEU229 |
| B | TYR245 |
| B | HOH1228 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 1007 |
| Chain | Residue |
| B | LEU53 |
| B | DDZ54 |
| B | ASN75 |
| B | HIS104 |
| B | TYR123 |
| B | TRP129 |
| B | HIS201 |
| B | LYS309 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 1001 |
| Chain | Residue |
| C | ASP14 |
| C | DDZ54 |
| C | LYS102 |
| C | ASP296 |
| C | HIS297 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 1002 |
| Chain | Residue |
| C | HIS333 |
| C | LEU334 |
| C | THR335 |
| site_id | AD7 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 C 1003 |
| Chain | Residue |
| C | LEU53 |
| C | DDZ54 |
| C | ASN75 |
| C | HIS104 |
| C | TYR123 |
| C | TRP129 |
| C | HIS201 |
| C | LYS309 |
| C | HOH1264 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue MG D 1001 |
| Chain | Residue |
| D | ASP14 |
| D | DDZ54 |
| D | ASP296 |
| D | HIS297 |
| D | SO41002 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 D 1002 |
| Chain | Residue |
| D | LEU53 |
| D | DDZ54 |
| D | ASN75 |
| D | HIS104 |
| D | TYR123 |
| D | HIS201 |
| D | LYS309 |
| D | MG1001 |
| site_id | AE1 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide LEU B 53 and DDZ B 54 |
| Chain | Residue |
| B | ARG58 |
| B | ASN75 |
| B | LYS102 |
| B | HIS104 |
| B | ASP296 |
| B | HIS297 |
| B | ALA385 |
| B | MG1001 |
| B | SO41007 |
| B | SER51 |
| B | PRO52 |
| B | ALA55 |
| B | PRO56 |
| B | ALA57 |
| site_id | AE2 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide DDZ B 54 and ALA B 55 |
| Chain | Residue |
| B | LEU53 |
| B | PRO56 |
| B | ALA57 |
| B | ARG58 |
| B | ALA59 |
| B | ASN75 |
| B | LYS102 |
| B | HIS104 |
| B | ASP296 |
| B | HIS297 |
| B | MG1001 |
| B | SO41007 |
| B | HOH1269 |
| site_id | AE3 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide LEU C 53 and DDZ C 54 |
| Chain | Residue |
| C | SER51 |
| C | PRO52 |
| C | ALA55 |
| C | PRO56 |
| C | ALA57 |
| C | ARG58 |
| C | ASN75 |
| C | LYS102 |
| C | HIS104 |
| C | ASP296 |
| C | HIS297 |
| C | ALA385 |
| C | MG1001 |
| C | SO41003 |
| site_id | AE4 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide DDZ C 54 and ALA C 55 |
| Chain | Residue |
| C | LEU53 |
| C | PRO56 |
| C | ALA57 |
| C | ARG58 |
| C | ALA59 |
| C | ASN75 |
| C | LYS102 |
| C | HIS104 |
| C | ASP296 |
| C | HIS297 |
| C | MG1001 |
| C | SO41003 |
| C | HOH1204 |
| site_id | AE5 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide LEU D 53 and DDZ D 54 |
| Chain | Residue |
| D | SER51 |
| D | PRO52 |
| D | ALA55 |
| D | PRO56 |
| D | ALA57 |
| D | ARG58 |
| D | ASN75 |
| D | HIS104 |
| D | HIS297 |
| D | ALA385 |
| D | MG1001 |
| D | SO41002 |
| site_id | AE6 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide DDZ D 54 and ALA D 55 |
| Chain | Residue |
| D | LEU53 |
| D | PRO56 |
| D | ALA57 |
| D | ARG58 |
| D | ALA59 |
| D | ASN75 |
| D | HIS104 |
| D | HIS297 |
| D | MG1001 |
| D | SO41002 |
| D | HOH1175 |
Functional Information from PROSITE/UniProt
| site_id | PS00149 |
| Number of Residues | 11 |
| Details | SULFATASE_2 Sulfatases signature 2. GYyTalSGK.MH |
| Chain | Residue | Details |
| A | GLY94-HIS104 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P15289 |
| Chain | Residue | Details |
| A | DDZ54 | |
| B | DDZ54 | |
| C | DDZ54 | |
| D | DDZ54 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P15289 |
| Chain | Residue | Details |
| A | HIS104 | |
| B | HIS104 | |
| C | HIS104 | |
| D | HIS104 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP14 | |
| A | GLN15 | |
| A | ASP296 | |
| A | HIS297 | |
| B | ASP14 | |
| B | GLN15 | |
| B | ASP296 | |
| B | HIS297 | |
| C | ASP14 | |
| C | GLN15 | |
| C | ASP296 | |
| C | HIS297 | |
| D | ASP14 | |
| D | GLN15 | |
| D | ASP296 | |
| D | HIS297 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: via 3-oxoalanine => ECO:0000250 |
| Chain | Residue | Details |
| A | DDZ54 | |
| B | DDZ54 | |
| C | DDZ54 | |
| D | DDZ54 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: 3-oxoalanine (Cys) => ECO:0000250|UniProtKB:P15289 |
| Chain | Residue | Details |
| A | DDZ54 | |
| B | DDZ54 | |
| C | DDZ54 | |
| D | DDZ54 |
