6G5L

Crystal structure of human carbonic anhydrase isozyme XII with 4-chloro-2-(cyclohexylamino)-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004089	molecular_function	carbonate dehydratase activity
A	0008270	molecular_function	zinc ion binding
B	0004089	molecular_function	carbonate dehydratase activity
B	0008270	molecular_function	zinc ion binding
C	0004089	molecular_function	carbonate dehydratase activity
C	0008270	molecular_function	zinc ion binding
D	0004089	molecular_function	carbonate dehydratase activity
D	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	HIS91
A	HIS93
A	HIS117
A	EM5302

---

site_id	AC2
Number of Residues	19
Details	binding site for residue EM5 A 302

Chain	Residue
A	HIS93
A	HIS117
A	ALA129
A	VAL141
A	LEU197
A	THR198
A	THR199
A	TRP208
A	ZN301
A	PEG304
A	HOH401
A	HOH405
A	HOH414
A	HOH538
A	TRP4
A	ASN64
A	HIS66
A	GLN89
A	HIS91

---

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 303

Chain	Residue
A	ASN134
A	SER136
A	PRO204
A	HOH404

---

site_id	AC4
Number of Residues	6
Details	binding site for residue PEG A 304

Chain	Residue
A	SER133
A	PRO201
A	ASN203
A	EM5302
A	HOH414
A	HOH552

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 305

Chain	Residue
A	GLY50
A	ASN52
A	LEU53
A	ASP75
B	GLN49

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN B 301

Chain	Residue
B	HIS91
B	HIS93
B	HIS117
B	EM5302

---

site_id	AC7
Number of Residues	18
Details	binding site for residue EM5 B 302

Chain	Residue
B	ASN64
B	HIS66
B	GLN89
B	HIS91
B	HIS93
B	HIS117
B	ALA129
B	SER130
B	VAL141
B	LEU197
B	THR198
B	THR199
B	TRP208
B	ZN301
B	EDO306
B	HOH404
B	HOH408
B	HOH569

---

site_id	AC8
Number of Residues	7
Details	binding site for residue EDO B 303

Chain	Residue
B	LEU183
B	PRO184
B	GLU185
B	VAL215
B	HOH414
B	HOH502
B	HOH544

---

site_id	AC9
Number of Residues	9
Details	binding site for residue EDO B 304

Chain	Residue
B	SER42
B	THR44
B	LEU46
B	GLY80
B	LEU81
B	TYR190
B	ARG192
B	HOH409
B	HOH578

---

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO B 305

Chain	Residue
B	ARG255
B	LEU256
B	TYR258
B	HOH510
B	HOH564

---

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO B 306

Chain	Residue
B	ASN64
B	LYS69
B	GLN89
B	EM5302
B	HOH453

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN C 301

Chain	Residue
C	HIS91
C	HIS93
C	HIS117
C	EM5302

---

site_id	AD4
Number of Residues	15
Details	binding site for residue EM5 C 302

Chain	Residue
C	TRP208
C	ZN301
C	HOH441
C	HOH478
C	HOH522
C	HOH562
C	GLN89
C	HIS91
C	HIS93
C	HIS117
C	ALA129
C	VAL141
C	LEU197
C	THR198
C	THR199

---

site_id	AD5
Number of Residues	5
Details	binding site for residue EDO C 303

Chain	Residue
C	PRO201
C	ASN203
C	HOH406
C	HOH510
C	HOH546

---

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN D 301

Chain	Residue
D	HIS91
D	HIS93
D	HIS117
D	EM5302

---

site_id	AD7
Number of Residues	13
Details	binding site for residue EM5 D 302

Chain	Residue
D	TRP4
D	GLN89
D	HIS91
D	HIS93
D	HIS117
D	VAL141
D	LEU197
D	THR198
D	THR199
D	TRP208
D	ZN301
D	HOH425
D	HOH539

---

site_id	AD8
Number of Residues	5
Details	binding site for residue EDO D 303

Chain	Residue
D	HIS33
D	SER34
D	SER108
D	HOH427
D	HOH586

---

site_id	AD9
Number of Residues	7
Details	binding site for residue EDO D 304

Chain	Residue
D	SER42
D	THR44
D	LEU46
D	GLY80
D	TYR190
D	ARG192
D	HOH499

---

site_id	AE1
Number of Residues	4
Details	binding site for residue EDO D 305

Chain	Residue
D	ASN134
D	ASN203
D	HOH403
D	HOH505

---

site_id	AE2
Number of Residues	6
Details	binding site for residue EDO D 306

Chain	Residue
A	GLU171
A	PHE173
D	HIS164
D	ALA172
D	PHE173
D	HOH424

---

site_id	AE3
Number of Residues	7
Details	binding site for residue PEG D 307

Chain	Residue
D	LEU26
D	ARG194
D	ARG255
D	LEU256
D	TYR258
D	HOH480
D	HOH532

---

site_id	AE4
Number of Residues	5
Details	binding site for residue EDO D 308

Chain	Residue
D	LYS251
D	PHE252
D	ASP253
D	HOH402
D	HOH461

---

Functional Information from PROSITE/UniProt

site_id	PS00162
Number of Residues	17
Details	ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVsgqhFaaELHIV

Chain	Residue	Details
A	SER103-VAL119

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11493685","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---