6G59
Structure of the alanine racemase from Staphylococcus aureus in complex with an pyridoxal-6- phosphate derivative
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006522 | biological_process | alanine metabolic process |
| A | 0008784 | molecular_function | alanine racemase activity |
| A | 0009252 | biological_process | peptidoglycan biosynthetic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0030632 | biological_process | D-alanine biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006522 | biological_process | alanine metabolic process |
| B | 0008784 | molecular_function | alanine racemase activity |
| B | 0009252 | biological_process | peptidoglycan biosynthetic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0030632 | biological_process | D-alanine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue EM2 A 401 |
| Chain | Residue |
| A | LYS39 |
| A | HOH525 |
| A | TYR43 |
| A | HIS168 |
| A | ASN203 |
| A | SER204 |
| A | ARG219 |
| A | GLY221 |
| A | ILE222 |
| A | TYR354 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | ALA-1 |
| A | GLY0 |
| A | PHE1 |
| A | SER2 |
| A | LYS4 |
| A | ASP143 |
| A | THR144 |
| A | ARG185 |
| A | HOH552 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | LYS49 |
| A | ARG52 |
| A | HIS76 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 404 |
| Chain | Residue |
| A | HIS240 |
| A | PRO243 |
| A | HIS335 |
| A | ARG336 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 405 |
| Chain | Residue |
| A | ARG290 |
| A | ILE291 |
| A | GLN293 |
| A | ARG309 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue NA A 406 |
| Chain | Residue |
| A | ILE154 |
| A | TYR157 |
| A | LEU160 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 407 |
| Chain | Residue |
| A | TYR227 |
| A | VAL245 |
| A | ASP333 |
| A | ASN334 |
| A | VAL342 |
| A | HOH574 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 408 |
| Chain | Residue |
| A | SER262 |
| A | SER264 |
| B | GLY135 |
| B | MET136 |
| B | ALA170 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 409 |
| Chain | Residue |
| A | HIS29 |
| A | PRO30 |
| A | ASN31 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| B | HIS240 |
| B | PRO243 |
| B | HIS335 |
| B | ARG336 |
| B | HOH542 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| B | TYR5 |
| B | TYR10 |
| B | ILE367 |
| B | ARG374 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue NA B 404 |
| Chain | Residue |
| B | ILE154 |
| B | TYR157 |
| B | LEU160 |
| B | HOH547 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 405 |
| Chain | Residue |
| B | HIS29 |
| B | ASN31 |
| B | LYS32 |
| site_id | AD5 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide EM2 B 401 and LYS B 39 |
| Chain | Residue |
| A | ASP313 |
| B | VAL37 |
| B | VAL38 |
| B | ALA40 |
| B | ASN41 |
| B | ALA42 |
| B | TYR43 |
| B | ALA63 |
| B | ALA65 |
| B | GLU69 |
| B | HIS168 |
| B | ASN203 |
| B | SER204 |
| B | ARG219 |
| B | GLY221 |
| B | ILE222 |
| B | TYR354 |
| B | HOH536 |
Functional Information from PROSITE/UniProt
| site_id | PS00395 |
| Number of Residues | 11 |
| Details | ALANINE_RACEMASE Alanine racemase pyridoxal-phosphate attachment site. AVvKANAYGLG |
| Chain | Residue | Details |
| A | ALA36-GLY46 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor; specific for D-alanine","evidences":[{"source":"PubMed","id":"22194336","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor; specific for L-alanine","evidences":[{"source":"PubMed","id":"22194336","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01201","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine"} |
| Chain | Residue | Details |
