6G56
Apo-structure of the alanine racemase from Staphylococcus aureus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006522 | biological_process | alanine metabolic process |
| A | 0008784 | molecular_function | alanine racemase activity |
| A | 0009252 | biological_process | peptidoglycan biosynthetic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0030632 | biological_process | D-alanine biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006522 | biological_process | alanine metabolic process |
| B | 0008784 | molecular_function | alanine racemase activity |
| B | 0009252 | biological_process | peptidoglycan biosynthetic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0030632 | biological_process | D-alanine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 401 |
| Chain | Residue |
| A | TYR43 |
| A | ASN203 |
| A | SER204 |
| A | GLY221 |
| A | ILE222 |
| A | TYR354 |
| A | HOH536 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | ASN31 |
| A | LYS32 |
| A | ASP211 |
| A | GLN213 |
| A | HOH621 |
| A | HIS29 |
| A | PRO30 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | TYR228 |
| A | GLN234 |
| A | HIS240 |
| A | LEU241 |
| A | ARG336 |
| A | HOH561 |
| A | HOH580 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 404 |
| Chain | Residue |
| A | TYR183 |
| A | LYS187 |
| A | CYS212 |
| A | GLN213 |
| A | PHE214 |
| A | HOH502 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 405 |
| Chain | Residue |
| A | LYS23 |
| A | GLN184 |
| A | LYS187 |
| A | HOH550 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 406 |
| Chain | Residue |
| A | SER107 |
| A | LYS108 |
| A | GLN109 |
| B | HOH608 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 407 |
| Chain | Residue |
| A | SER264 |
| A | GLY266 |
| A | HOH510 |
| B | ARG138 |
| B | HIS168 |
| B | PHE169 |
| B | CYS171 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 408 |
| Chain | Residue |
| A | ASN16 |
| A | ALA19 |
| A | HIS53 |
| A | ASN57 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 409 |
| Chain | Residue |
| A | CYS311 |
| A | MET312 |
| A | ASP313 |
| A | GLN314 |
| B | LYS39 |
| B | ARG138 |
| B | GOL418 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 401 |
| Chain | Residue |
| B | TYR43 |
| B | ASN203 |
| B | SER204 |
| B | GLY221 |
| B | ILE222 |
| B | TYR354 |
| B | HOH507 |
| B | HOH578 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| B | TYR228 |
| B | GLN234 |
| B | HIS240 |
| B | LEU241 |
| B | ARG336 |
| B | HOH532 |
| B | HOH561 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| B | TYR183 |
| B | LYS187 |
| B | CYS212 |
| B | GLN213 |
| B | PHE214 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 404 |
| Chain | Residue |
| B | ASP143 |
| B | THR144 |
| B | ARG185 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 405 |
| Chain | Residue |
| B | GLN184 |
| B | LYS187 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 406 |
| Chain | Residue |
| A | ARG74 |
| A | HIS99 |
| A | HOH600 |
| B | GLU149 |
| B | GLU152 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 407 |
| Chain | Residue |
| A | ARG100 |
| A | LYS124 |
| B | LYS108 |
| B | LYS112 |
| B | GLU149 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 408 |
| Chain | Residue |
| B | LYS142 |
| B | ASP143 |
| B | THR146 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 409 |
| Chain | Residue |
| A | LYS116 |
| B | MET210 |
| B | ASP211 |
| B | CYS212 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 410 |
| Chain | Residue |
| B | ASN31 |
| B | LYS32 |
| B | GLN213 |
| B | HOH509 |
| A | LYS108 |
| A | LYS112 |
| B | HIS29 |
| B | PRO30 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 411 |
| Chain | Residue |
| B | ASN16 |
| B | ALA19 |
| B | HIS53 |
| B | ASN57 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 412 |
| Chain | Residue |
| B | LYS49 |
| B | ARG52 |
| B | HIS76 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 413 |
| Chain | Residue |
| B | ARG74 |
| B | HIS99 |
| B | ARG100 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 414 |
| Chain | Residue |
| B | LYS124 |
| B | LYS125 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 415 |
| Chain | Residue |
| A | GLU197 |
| B | TYR157 |
| B | GLU158 |
| B | GLN159 |
| B | HOH571 |
| site_id | AE7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 416 |
| Chain | Residue |
| B | GLU174 |
| B | SER230 |
| B | GLU231 |
| site_id | AE8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 417 |
| Chain | Residue |
| A | LYS39 |
| B | TYR265 |
| B | CYS311 |
| B | MET312 |
| B | ASP313 |
| B | HOH580 |
| site_id | AE9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 418 |
| Chain | Residue |
| A | GOL409 |
| B | ARG138 |
| B | PHE166 |
| B | HIS168 |
| B | ASN203 |
| B | ARG219 |
| B | HOH501 |
| B | HOH550 |
Functional Information from PROSITE/UniProt
| site_id | PS00395 |
| Number of Residues | 11 |
| Details | ALANINE_RACEMASE Alanine racemase pyridoxal-phosphate attachment site. AVvKANAYGLG |
| Chain | Residue | Details |
| A | ALA36-GLY46 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor; specific for D-alanine","evidences":[{"source":"PubMed","id":"22194336","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor; specific for L-alanine","evidences":[{"source":"PubMed","id":"22194336","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01201","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine"} |
| Chain | Residue | Details |
