6G2I

Filament of acetyl-CoA carboxylase and BRCT domains of BRCA1 (ACC-BRCT) at 5.9 A resolution

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001650	cellular_component	fibrillar center
A	0001894	biological_process	tissue homeostasis
A	0003824	molecular_function	catalytic activity
A	0003989	molecular_function	acetyl-CoA carboxylase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006084	biological_process	acetyl-CoA metabolic process
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006637	biological_process	acyl-CoA metabolic process
A	0008610	biological_process	lipid biosynthetic process
A	0015629	cellular_component	actin cytoskeleton
A	0016874	molecular_function	ligase activity
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0046949	biological_process	fatty-acyl-CoA biosynthetic process
A	0051289	biological_process	protein homotetramerization
A	0055088	biological_process	lipid homeostasis
A	0071380	biological_process	cellular response to prostaglandin E stimulus
A	2001295	biological_process	malonyl-CoA biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0001650	cellular_component	fibrillar center
B	0001894	biological_process	tissue homeostasis
B	0003824	molecular_function	catalytic activity
B	0003989	molecular_function	acetyl-CoA carboxylase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006084	biological_process	acetyl-CoA metabolic process
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0006637	biological_process	acyl-CoA metabolic process
B	0008610	biological_process	lipid biosynthetic process
B	0015629	cellular_component	actin cytoskeleton
B	0016874	molecular_function	ligase activity
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0046949	biological_process	fatty-acyl-CoA biosynthetic process
B	0051289	biological_process	protein homotetramerization
B	0055088	biological_process	lipid homeostasis
B	0071380	biological_process	cellular response to prostaglandin E stimulus
B	2001295	biological_process	malonyl-CoA biosynthetic process
C	0000166	molecular_function	nucleotide binding
C	0001650	cellular_component	fibrillar center
C	0001894	biological_process	tissue homeostasis
C	0003824	molecular_function	catalytic activity
C	0003989	molecular_function	acetyl-CoA carboxylase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006084	biological_process	acetyl-CoA metabolic process
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0006637	biological_process	acyl-CoA metabolic process
C	0008610	biological_process	lipid biosynthetic process
C	0015629	cellular_component	actin cytoskeleton
C	0016874	molecular_function	ligase activity
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0046949	biological_process	fatty-acyl-CoA biosynthetic process
C	0051289	biological_process	protein homotetramerization
C	0055088	biological_process	lipid homeostasis
C	0071380	biological_process	cellular response to prostaglandin E stimulus
C	2001295	biological_process	malonyl-CoA biosynthetic process
D	0000166	molecular_function	nucleotide binding
D	0001650	cellular_component	fibrillar center
D	0001894	biological_process	tissue homeostasis
D	0003824	molecular_function	catalytic activity
D	0003989	molecular_function	acetyl-CoA carboxylase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006084	biological_process	acetyl-CoA metabolic process
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0006637	biological_process	acyl-CoA metabolic process
D	0008610	biological_process	lipid biosynthetic process
D	0015629	cellular_component	actin cytoskeleton
D	0016874	molecular_function	ligase activity
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0046949	biological_process	fatty-acyl-CoA biosynthetic process
D	0051289	biological_process	protein homotetramerization
D	0055088	biological_process	lipid homeostasis
D	0071380	biological_process	cellular response to prostaglandin E stimulus
D	2001295	biological_process	malonyl-CoA biosynthetic process
E	0000166	molecular_function	nucleotide binding
E	0001650	cellular_component	fibrillar center
E	0001894	biological_process	tissue homeostasis
E	0003824	molecular_function	catalytic activity
E	0003989	molecular_function	acetyl-CoA carboxylase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0006084	biological_process	acetyl-CoA metabolic process
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0006633	biological_process	fatty acid biosynthetic process
E	0006637	biological_process	acyl-CoA metabolic process
E	0008610	biological_process	lipid biosynthetic process
E	0015629	cellular_component	actin cytoskeleton
E	0016874	molecular_function	ligase activity
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
E	0046949	biological_process	fatty-acyl-CoA biosynthetic process
E	0051289	biological_process	protein homotetramerization
E	0055088	biological_process	lipid homeostasis
E	0071380	biological_process	cellular response to prostaglandin E stimulus
E	2001295	biological_process	malonyl-CoA biosynthetic process
F	0000166	molecular_function	nucleotide binding
F	0001650	cellular_component	fibrillar center
F	0001894	biological_process	tissue homeostasis
F	0003824	molecular_function	catalytic activity
F	0003989	molecular_function	acetyl-CoA carboxylase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0006084	biological_process	acetyl-CoA metabolic process
F	0006629	biological_process	lipid metabolic process
F	0006631	biological_process	fatty acid metabolic process
F	0006633	biological_process	fatty acid biosynthetic process
F	0006637	biological_process	acyl-CoA metabolic process
F	0008610	biological_process	lipid biosynthetic process
F	0015629	cellular_component	actin cytoskeleton
F	0016874	molecular_function	ligase activity
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
F	0046949	biological_process	fatty-acyl-CoA biosynthetic process
F	0051289	biological_process	protein homotetramerization
F	0055088	biological_process	lipid homeostasis
F	0071380	biological_process	cellular response to prostaglandin E stimulus
F	2001295	biological_process	malonyl-CoA biosynthetic process
G	0000166	molecular_function	nucleotide binding
G	0001650	cellular_component	fibrillar center
G	0001894	biological_process	tissue homeostasis
G	0003824	molecular_function	catalytic activity
G	0003989	molecular_function	acetyl-CoA carboxylase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005829	cellular_component	cytosol
G	0006084	biological_process	acetyl-CoA metabolic process
G	0006629	biological_process	lipid metabolic process
G	0006631	biological_process	fatty acid metabolic process
G	0006633	biological_process	fatty acid biosynthetic process
G	0006637	biological_process	acyl-CoA metabolic process
G	0008610	biological_process	lipid biosynthetic process
G	0015629	cellular_component	actin cytoskeleton
G	0016874	molecular_function	ligase activity
G	0042802	molecular_function	identical protein binding
G	0046872	molecular_function	metal ion binding
G	0046949	biological_process	fatty-acyl-CoA biosynthetic process
G	0051289	biological_process	protein homotetramerization
G	0055088	biological_process	lipid homeostasis
G	0071380	biological_process	cellular response to prostaglandin E stimulus
G	2001295	biological_process	malonyl-CoA biosynthetic process
H	0003677	molecular_function	DNA binding
H	0004842	molecular_function	ubiquitin-protein transferase activity
H	0005634	cellular_component	nucleus
H	0006281	biological_process	DNA repair
H	0006974	biological_process	DNA damage response
H	0008270	molecular_function	zinc ion binding
J	0000166	molecular_function	nucleotide binding
J	0001650	cellular_component	fibrillar center
J	0001894	biological_process	tissue homeostasis
J	0003824	molecular_function	catalytic activity
J	0003989	molecular_function	acetyl-CoA carboxylase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005829	cellular_component	cytosol
J	0006084	biological_process	acetyl-CoA metabolic process
J	0006629	biological_process	lipid metabolic process
J	0006631	biological_process	fatty acid metabolic process
J	0006633	biological_process	fatty acid biosynthetic process
J	0006637	biological_process	acyl-CoA metabolic process
J	0008610	biological_process	lipid biosynthetic process
J	0015629	cellular_component	actin cytoskeleton
J	0016874	molecular_function	ligase activity
J	0042802	molecular_function	identical protein binding
J	0046872	molecular_function	metal ion binding
J	0046949	biological_process	fatty-acyl-CoA biosynthetic process
J	0051289	biological_process	protein homotetramerization
J	0055088	biological_process	lipid homeostasis
J	0071380	biological_process	cellular response to prostaglandin E stimulus
J	2001295	biological_process	malonyl-CoA biosynthetic process
K	0003677	molecular_function	DNA binding
K	0004842	molecular_function	ubiquitin-protein transferase activity
K	0005634	cellular_component	nucleus
K	0006281	biological_process	DNA repair
K	0006974	biological_process	DNA damage response
K	0008270	molecular_function	zinc ion binding
M	0003677	molecular_function	DNA binding
M	0004842	molecular_function	ubiquitin-protein transferase activity
M	0005634	cellular_component	nucleus
M	0006281	biological_process	DNA repair
M	0006974	biological_process	DNA damage response
M	0008270	molecular_function	zinc ion binding
O	0003677	molecular_function	DNA binding
O	0004842	molecular_function	ubiquitin-protein transferase activity
O	0005634	cellular_component	nucleus
O	0006281	biological_process	DNA repair
O	0006974	biological_process	DNA damage response
O	0008270	molecular_function	zinc ion binding
Q	0000166	molecular_function	nucleotide binding
Q	0001650	cellular_component	fibrillar center
Q	0001894	biological_process	tissue homeostasis
Q	0003824	molecular_function	catalytic activity
Q	0003989	molecular_function	acetyl-CoA carboxylase activity
Q	0005515	molecular_function	protein binding
Q	0005524	molecular_function	ATP binding
Q	0005737	cellular_component	cytoplasm
Q	0005739	cellular_component	mitochondrion
Q	0005829	cellular_component	cytosol
Q	0006084	biological_process	acetyl-CoA metabolic process
Q	0006629	biological_process	lipid metabolic process
Q	0006631	biological_process	fatty acid metabolic process
Q	0006633	biological_process	fatty acid biosynthetic process
Q	0006637	biological_process	acyl-CoA metabolic process
Q	0008610	biological_process	lipid biosynthetic process
Q	0015629	cellular_component	actin cytoskeleton
Q	0016874	molecular_function	ligase activity
Q	0042802	molecular_function	identical protein binding
Q	0046872	molecular_function	metal ion binding
Q	0046949	biological_process	fatty-acyl-CoA biosynthetic process
Q	0051289	biological_process	protein homotetramerization
Q	0055088	biological_process	lipid homeostasis
Q	0071380	biological_process	cellular response to prostaglandin E stimulus
Q	2001295	biological_process	malonyl-CoA biosynthetic process
R	0000166	molecular_function	nucleotide binding
R	0001650	cellular_component	fibrillar center
R	0001894	biological_process	tissue homeostasis
R	0003824	molecular_function	catalytic activity
R	0003989	molecular_function	acetyl-CoA carboxylase activity
R	0005515	molecular_function	protein binding
R	0005524	molecular_function	ATP binding
R	0005737	cellular_component	cytoplasm
R	0005739	cellular_component	mitochondrion
R	0005829	cellular_component	cytosol
R	0006084	biological_process	acetyl-CoA metabolic process
R	0006629	biological_process	lipid metabolic process
R	0006631	biological_process	fatty acid metabolic process
R	0006633	biological_process	fatty acid biosynthetic process
R	0006637	biological_process	acyl-CoA metabolic process
R	0008610	biological_process	lipid biosynthetic process
R	0015629	cellular_component	actin cytoskeleton
R	0016874	molecular_function	ligase activity
R	0042802	molecular_function	identical protein binding
R	0046872	molecular_function	metal ion binding
R	0046949	biological_process	fatty-acyl-CoA biosynthetic process
R	0051289	biological_process	protein homotetramerization
R	0055088	biological_process	lipid homeostasis
R	0071380	biological_process	cellular response to prostaglandin E stimulus
R	2001295	biological_process	malonyl-CoA biosynthetic process
S	0003677	molecular_function	DNA binding
S	0004842	molecular_function	ubiquitin-protein transferase activity
S	0005634	cellular_component	nucleus
S	0006281	biological_process	DNA repair
S	0006974	biological_process	DNA damage response
S	0008270	molecular_function	zinc ion binding
U	0003677	molecular_function	DNA binding
U	0004842	molecular_function	ubiquitin-protein transferase activity
U	0005634	cellular_component	nucleus
U	0006281	biological_process	DNA repair
U	0006974	biological_process	DNA damage response
U	0008270	molecular_function	zinc ion binding
W	0003677	molecular_function	DNA binding
W	0004842	molecular_function	ubiquitin-protein transferase activity
W	0005634	cellular_component	nucleus
W	0006281	biological_process	DNA repair
W	0006974	biological_process	DNA damage response
W	0008270	molecular_function	zinc ion binding
Y	0003677	molecular_function	DNA binding
Y	0004842	molecular_function	ubiquitin-protein transferase activity
Y	0005634	cellular_component	nucleus
Y	0006281	biological_process	DNA repair
Y	0006974	biological_process	DNA damage response
Y	0008270	molecular_function	zinc ion binding

Functional Information from PROSITE/UniProt

site_id	PS00188
Number of Residues	18
Details	BIOTIN Biotin-requiring enzymes attachment site. GQcYaeIeVMKMvmtLtA

Chain	Residue	Details
D	GLY776-ALA793

---

site_id	PS00866
Number of Residues	15
Details	CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. YPVMIKASeggGGkG

Chain	Residue	Details
D	TYR306-GLY320

---

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. FLELNPRL

Chain	Residue	Details
D	PHE435-LEU442

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2028
Details	Domain: {"description":"CoA carboxyltransferase N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU01136","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2528
Details	Domain: {"description":"CoA carboxyltransferase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU01137","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3948
Details	Region: {"description":"Carboxyltransferase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01138","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00409","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00409","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00969","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	24
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	16
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Modified residue: {"description":"N6-biotinyllysine","evidences":[{"source":"UniProtKB","id":"P11497","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU01066","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16698035","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29899443","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	792
Details	Domain: {"description":"BRCT 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00033","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---