6G1P
Apo form of ADP-ribosylserine hydrolase ARH3 of Latimeria chalumnae
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004649 | molecular_function | poly(ADP-ribose) glycohydrolase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005694 | cellular_component | chromosome |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006281 | biological_process | DNA repair |
| A | 0006974 | biological_process | DNA damage response |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0060546 | biological_process | negative regulation of necroptotic process |
| A | 0140290 | biological_process | peptidyl-serine ADP-deribosylation |
| A | 0140292 | molecular_function | ADP-ribosylserine hydrolase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004649 | molecular_function | poly(ADP-ribose) glycohydrolase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005694 | cellular_component | chromosome |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006281 | biological_process | DNA repair |
| B | 0006974 | biological_process | DNA damage response |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0060546 | biological_process | negative regulation of necroptotic process |
| B | 0140290 | biological_process | peptidyl-serine ADP-deribosylation |
| B | 0140292 | molecular_function | ADP-ribosylserine hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 401 |
| Chain | Residue |
| A | THR62 |
| A | ASP63 |
| A | ASP64 |
| A | ASP305 |
| A | HOH523 |
| A | HOH742 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue CIT A 402 |
| Chain | Residue |
| A | GLY103 |
| A | ALA104 |
| A | GLY136 |
| A | ASN137 |
| A | GLY138 |
| A | MET141 |
| A | HIS168 |
| A | ILE260 |
| A | HOH508 |
| A | HOH521 |
| A | HOH547 |
| B | GLU33 |
| A | ASP63 |
| A | GLY101 |
| A | TYR102 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 403 |
| Chain | Residue |
| A | TYR118 |
| A | SER119 |
| A | ASP120 |
| A | HOH545 |
| A | HOH776 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 404 |
| Chain | Residue |
| A | GLU51 |
| A | LEU286 |
| A | GLN291 |
| A | HOH512 |
| A | HOH567 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue ACT A 405 |
| Chain | Residue |
| A | ARG48 |
| A | LYS52 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 406 |
| Chain | Residue |
| A | MET9 |
| A | GLN14 |
| A | LEU188 |
| A | GLN189 |
| A | HOH728 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 407 |
| Chain | Residue |
| A | GLU191 |
| A | TYR318 |
| A | TYR319 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 408 |
| Chain | Residue |
| A | ALA37 |
| A | VAL38 |
| A | SER299 |
| A | LEU300 |
| A | GLY301 |
| A | HOH504 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 409 |
| Chain | Residue |
| A | GLN108 |
| A | LYS111 |
| B | GLU31 |
| B | PHE46 |
| B | LEU49 |
| B | LEU50 |
| B | THR58 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 410 |
| Chain | Residue |
| A | ASP80 |
| A | ASP155 |
| A | PHE159 |
| A | GLN352 |
| A | HOH529 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 401 |
| Chain | Residue |
| B | THR62 |
| B | ASP63 |
| B | ASP64 |
| B | ASP305 |
| B | HOH554 |
| B | HOH735 |
| site_id | AD3 |
| Number of Residues | 15 |
| Details | binding site for residue CIT B 402 |
| Chain | Residue |
| A | GLU33 |
| B | ASP63 |
| B | GLY101 |
| B | TYR102 |
| B | GLY103 |
| B | ALA104 |
| B | GLY136 |
| B | ASN137 |
| B | GLY138 |
| B | MET141 |
| B | HIS168 |
| B | ILE260 |
| B | HOH505 |
| B | HOH518 |
| B | HOH548 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 403 |
| Chain | Residue |
| B | PHE122 |
| B | ARG126 |
| B | GLN165 |
| B | HOH704 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 404 |
| Chain | Residue |
| B | GLU51 |
| B | LEU286 |
| B | GLN291 |
| B | HOH527 |
| B | HOH597 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue ACT B 405 |
| Chain | Residue |
| B | ASN288 |
| B | ASP322 |
| B | HOH726 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 406 |
| Chain | Residue |
| B | HOH713 |
| B | ALA37 |
| B | VAL38 |
| B | ALA250 |
| B | SER299 |
| B | LEU300 |
| B | GLY301 |
| B | HOH502 |
| site_id | AD8 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 407 |
| Chain | Residue |
| A | SER35 |
| A | ASP36 |
| A | HOH522 |
| B | PHE129 |
| B | SER134 |
| B | TYR135 |
| B | GLY136 |
| B | ILE260 |
| B | ALA261 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 408 |
| Chain | Residue |
| A | GLU31 |
| A | PHE46 |
| A | LEU49 |
| A | LEU50 |
| A | THR58 |
| B | GLN108 |
| B | LYS111 |
| B | HOH637 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 409 |
| Chain | Residue |
| B | ARG126 |
| B | GLY131 |
| B | LYS132 |
| B | GLY133 |
| B | ALA169 |
| B | HOH564 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"34321462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AQM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30472116","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34321462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7AQM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30472116","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Glutamate flap","evidences":[{"source":"UniProtKB","id":"Q9NX46","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
