6G1M

Amine Dehydrogenase from Petrotoga mobilis; open and closed form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008839	molecular_function	4-hydroxy-tetrahydrodipicolinate reductase activity
A	0009089	biological_process	L-lysine biosynthetic process via diaminopimelate
A	0047530	molecular_function	2,4-diaminopentanoate dehydrogenase activity
B	0008839	molecular_function	4-hydroxy-tetrahydrodipicolinate reductase activity
B	0009089	biological_process	L-lysine biosynthetic process via diaminopimelate
B	0047530	molecular_function	2,4-diaminopentanoate dehydrogenase activity
C	0008839	molecular_function	4-hydroxy-tetrahydrodipicolinate reductase activity
C	0009089	biological_process	L-lysine biosynthetic process via diaminopimelate
C	0047530	molecular_function	2,4-diaminopentanoate dehydrogenase activity
D	0008839	molecular_function	4-hydroxy-tetrahydrodipicolinate reductase activity
D	0009089	biological_process	L-lysine biosynthetic process via diaminopimelate
D	0047530	molecular_function	2,4-diaminopentanoate dehydrogenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue NAD A 401

Chain	Residue
A	TRP7
A	THR76
A	ASN77
A	SER78
A	GLN86
A	ILE100
A	GLU102
A	THR132
A	GLY133
A	VAL134
A	ASN135
A	GLY8
A	PRO136
A	THR303
A	HOH510
A	GLY10
A	ALA11
A	MET12
A	HIS32
A	ASP33
A	PHE34
A	ALA75

---

site_id	AC2
Number of Residues	4
Details	binding site for residue PO4 A 402

Chain	Residue
A	ASN135
A	ARG161
A	HIS264
A	GLY299

---

site_id	AC3
Number of Residues	29
Details	binding site for residue NAD B 401

Chain	Residue
B	TRP7
B	PHE9
B	GLY10
B	ALA11
B	MET12
B	HIS32
B	ASP33
B	PHE34
B	ARG35
B	ALA75
B	THR76
B	ASN77
B	SER78
B	GLN86
B	ILE100
B	GLU102
B	THR132
B	GLY133
B	VAL134
B	ASN135
B	PRO136
B	PHE168
B	GLY169
B	PRO170
B	THR171
B	VAL172
B	THR303
B	HOH509
B	HOH525

---

site_id	AC4
Number of Residues	28
Details	binding site for residue NAD C 401

Chain	Residue
B	LYS190
C	TRP7
C	PHE9
C	GLY10
C	ALA11
C	MET12
C	HIS32
C	ASP33
C	PHE34
C	ARG35
C	ALA75
C	ASN77
C	SER78
C	GLN86
C	ILE100
C	GLU102
C	THR132
C	GLY133
C	VAL134
C	ASN135
C	PRO136
C	PHE168
C	GLY169
C	PRO170
C	THR171
C	VAL172
C	THR303
C	HOH502

---

site_id	AC5
Number of Residues	21
Details	binding site for residue NAD D 401

Chain	Residue
D	VAL134
D	ASN135
D	PRO136
D	THR303
D	HOH523
D	TRP7
D	GLY8
D	GLY10
D	ALA11
D	MET12
D	HIS32
D	ASP33
D	PHE34
D	ARG35
D	ALA75
D	ASN77
D	SER78
D	GLN86
D	ILE100
D	GLU102
D	THR132

---

site_id	AC6
Number of Residues	6
Details	binding site for residue PO4 D 402

Chain	Residue
D	VAL134
D	ASN135
D	ARG161
D	HIS264
D	GLY299
D	HOH510

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2019","firstPage":"324","lastPage":"333","volume":"2","journal":"Nat. Catal.","title":"A family of native amine dehydrogenases for the asymmetric reductive amination of ketones.","authors":["Mayol O.","Bastard K.","Beloti L.","Frese A.","Turkenburg J.P.","Petit J.-L.","Mariage A.","Debard A.","Pellouin V.","Perret A.","de Berardinis V.","Zaparucha A.","Grogan G.","Vergne-Vaxelaire C."],"citationCrossReferences":[{"database":"DOI","id":"10.1038/s41929-019-0249-z"}]}},{"source":"PDB","id":"6G1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6G1M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2019","firstPage":"324","lastPage":"333","volume":"2","journal":"Nat. Catal.","title":"A family of native amine dehydrogenases for the asymmetric reductive amination of ketones.","authors":["Mayol O.","Bastard K.","Beloti L.","Frese A.","Turkenburg J.P.","Petit J.-L.","Mariage A.","Debard A.","Pellouin V.","Perret A.","de Berardinis V.","Zaparucha A.","Grogan G.","Vergne-Vaxelaire C."],"citationCrossReferences":[{"database":"DOI","id":"10.1038/s41929-019-0249-z"}]}},{"source":"PDB","id":"6G1H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2019","firstPage":"324","lastPage":"333","volume":"2","journal":"Nat. Catal.","title":"A family of native amine dehydrogenases for the asymmetric reductive amination of ketones.","authors":["Mayol O.","Bastard K.","Beloti L.","Frese A.","Turkenburg J.P.","Petit J.-L.","Mariage A.","Debard A.","Pellouin V.","Perret A.","de Berardinis V.","Zaparucha A.","Grogan G.","Vergne-Vaxelaire C."],"citationCrossReferences":[{"database":"DOI","id":"10.1038/s41929-019-0249-z"}]}},{"source":"PDB","id":"6G1M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Involved in the activation of ammonia","evidences":[{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"journal article","publicationDate":"2019","firstPage":"324","lastPage":"333","volume":"2","journal":"Nat. Catal.","title":"A family of native amine dehydrogenases for the asymmetric reductive amination of ketones.","authors":["Mayol O.","Bastard K.","Beloti L.","Frese A.","Turkenburg J.P.","Petit J.-L.","Mariage A.","Debard A.","Pellouin V.","Perret A.","de Berardinis V.","Zaparucha A.","Grogan G.","Vergne-Vaxelaire C."],"citationCrossReferences":[{"database":"DOI","id":"10.1038/s41929-019-0249-z"}]}}]}

Chain

Residue

Details

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