6FW2

Crystal Structure of human mARC1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0003824	molecular_function	catalytic activity
A	0009253	biological_process	peptidoglycan catabolic process
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0030151	molecular_function	molybdenum ion binding
A	0030170	molecular_function	pyridoxal phosphate binding
A	0030430	cellular_component	host cell cytoplasm
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0044659	biological_process	viral release from host cell by cytolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue MTE A 1201

Chain	Residue
A	LYS67
A	LEU214
A	PHE237
A	ARG238
A	ASN240
A	CYS270
A	SER271
A	CYS273
A	TYR317
A	EFK1202
A	HOH1359
A	SER68
A	HOH1426
A	HOH1536
A	ASP91
A	ARG92
A	ASP209
A	THR210
A	SER211
A	PRO212
A	PHE213

---

site_id	AC2
Number of Residues	5
Details	binding site for residue EFK A 1202

Chain	Residue
A	SER271
A	ARG272
A	CYS273
A	THR276
A	MTE1201

---

site_id	AC3
Number of Residues	17
Details	binding site for residue B3P A 1203

Chain	Residue
A	GLU1011
A	ASP1020
A	GLY1030
A	HIS1031
A	LEU1032
A	ASP1070
A	PHE1104
A	GLN1105
A	ARG1145
A	HOH1317
A	HOH1320
A	HOH1340
A	HOH1365
A	HOH1369
A	HOH1398
A	HOH1416
A	HOH1477

---

site_id	AC4
Number of Residues	3
Details	binding site for residue MOO A 1204

Chain	Residue
A	ARG1014
A	LEU1015
A	LYS1016

---

site_id	AC5
Number of Residues	7
Details	binding site for residue MOO A 1205

Chain	Residue
A	GLY1113
A	PHE1114
A	THR1115
A	ASN1116
A	SER1117
A	ASN1132
A	HOH1417

---

site_id	AC6
Number of Residues	7
Details	binding site for residue MOO A 1206

Chain	Residue
A	ARG188
A	TRP1126
A	HOH1301
A	HOH1304
A	HOH1305
A	HOH1450
A	HOH1458

---

site_id	AC7
Number of Residues	7
Details	binding site for residue MOO A 1207

Chain	Residue
A	THR1142
A	PRO1143
A	ASN1144
A	ARG1145
A	HOH1379
A	HOH1491
A	HOH1506

---

site_id	AC8
Number of Residues	4
Details	binding site for residue PO4 A 1208

Chain	Residue
A	ARG200
A	PRO201
A	LYS202
A	HOH1374

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	11
Details	BINDING: BINDING => ECO:0000269|PubMed:30397129, ECO:0007744|PDB:6FW2

Chain	Residue	Details
A	LYS67
A	CYS273
A	TYR317
A	SER68
A	ARG92
A	THR210
A	SER211
A	ARG238
A	ASN240
A	SER271
A	ARG272

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	GLU1011

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	ASP1020

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:8266098

Chain	Residue	Details
A	LEU1032
A	PHE1104

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000303|PubMed:7831309

Chain	Residue	Details
A	SER1117
A	ASN1132

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 921

Chain	Residue	Details
A	GLU1011	proton shuttle (general acid/base)
A	ASP1020	covalent catalysis

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